Biomedical subjects

M Vasáková

Publications and source records attributed to M Vasáková.

6 recordsLinked to original sources

PubMed2003

[Results of treatment of multiresistant tuberculosis].

BACKGROUND: Multidrug resistant tuberculosis (MDR TB) is an infectious disease with limited therapeutic possibilities. Beside its epidemiological importance, MDR TB represents a problem also for long-term therapy with antituberculous drug combination and for its economical costs. METHODS AND RESULTS: We evaluated retrospectively the effect of treatment of MDR TB according to the clinical, radiological and bacteriological findings of 11 patients hospitalised in our department in years 1996 to 2000. Individual chemotherapy regimens were chosen according to the susceptibility test results for the first and second-line antituberculosis drugs. Despite the fully controlled and long-term treatment, seven patients died during the regimen; in three of them the cause of death was different from MDR TB. CONCLUSIONS: Prevalence of MDR TB cases in the Czech republic has remained in the same level for several previous years and it represents about 20-30 persons. To prevent acquired resistance with its negative consequences, it would be optimal to implement the recommended standardized treatment regimens.

Female↗

PubMed2001

Erdheim-Chester disease. A case report.

A 63-year old man had a history of diabetes insipidus, arthralgias and myalgias, weight loss, relapsing fever and malaise. Increased uptake of Tc-99m was found predominantly in distal antebrachia, in distal femurs and in both trochanters and tibias on the bone scintigraphy. The chest radiograph showed reticulonodular pattern and the high resolution computed tomography (HRCT) scans revealed diffuse infiltrative lung disease with small multiple nodules and widening of interlobular septs. Videothoracoscopic lung biopsy and biopsy of tibial lesion were perfomed. The histopathologic examination proved non-Langerhans cell histiocytosis-Erdheim-Chester disease. Treatment with prednisone reduced the pain and fever and improved the vital capacity of the lungs while the changes in the lungs and bones remained unchanged.

Biopsy↗

PubMed1998

[Extrapulmonary tuberculosis].

Extrapulmonary tuberculosis has a lower incidence than pulmonary tuberculosis. Almost always postprimary tuberculosis is involved, i.e. tuberculosis which develops with a certain latency after primoinfection with Mycobacterium tuberculosis. The latency period in different organs and systems differs, it is shortest in tuberculous pleuritis and basilar meningitis-3 months, and longest in affections of the urogenital tract-up to 10 years. The serious character of extrapulmonary tuberculosis is frequently due to its late diagnosis as extrapulmonary tuberculosis is usually not assumed and also because detection of a specific inflammation in poorly accessible parts is difficult, and last not least, also due to the complicated course of the disease, which frequently calls for a multidisciplinary approach.

Humans↗

PubMed1997

[Clinicopathologic correlation of interstitial pulmonary processes].

"Not-specified interstitial" lesions represented mostly cryptogenic fibrous alveolitis, extrinsic allergic bronchioloalveolitis prevailed among "disseminated" lesions, "infiltrative" lesions were proved to be extrinsic alveolitis or disseminated carcinoma. Among more definitely formulated suppositions of the clinician, cryptogenic alveolitis was proved in more then 50% of cases often modified by extensive fibrosis, organized pneumonia, cholesterol pneumonia or minute desquamative pattern. A similar relation of diagnostic correctness was found in allergic bronchioloalveolitis suprisingly often modified again by fibrosis and cholesterol pneumonia. Valid diagnoses were found in sarcoidosis, presumed Goodpasture syndrome harboured only pneumoconiotic stigmatization. In brief: Bioptical diagnosis nearly always replaced a vague clinical evaluation whereas definite nosological formulations were proved, turned more exact or changed in equal proportions, biopsy was not found contributory but in two cases.

Biopsy↗

PubMed1996

[High-resolution computer tomography in the diagnosis of cryptogenic fibrosing alveolitis. Correlation with pulmonary function and bronchoalveolar lavage].

BACKGROUND: High resolution computed tomography (HRCT) revealed new findings as regards changes associated with cryptogenic fibrotizing alveolitis. So far views on changes suggesting activity of the disease are not uniform and they were not yet confronted with examinations of fluid obtained by bronchoalveolar lavage (BALT). The objective of the present work is to evaluate the contribution of HRCT to the assessment of the activity of the disease and compare the findings with the examination of BALT. METHODS AND RESULTS: The authors evaluated the HRCT examination made in 52 patients with histologically confirmed cryptogenic fibrotizing alveolitis and in 39 of them the finding was confronted with the BALT examination. Signs of active inflammatory disease according to HRCT comprised a ground-glass increase of the density in 80.8%, centrilobular micronodules in 17.3% and a prominence of centrilobular structures in 32.7%. The suggested extent of affection of the pulmonary parenchyma assessed according to HRCT correlated well with the degree of dyspnoea, restrictive and obstructive ventilation disorder, pulmonary diffusion and with hypoxaemia. The authors confirmed also an inverse correlation between the grade assessed by HRCT and the percentage of lymphocytes in BALT. CONCLUSIONS: The investigation confirmed the contribution of HRCT in the diagnosis of patients with cryptogenic fibrotizing alveolitis, it confirmed the complementary importance of HRCT and BALT examination when assessing the activity of the disease and its asset when monitoring patients during treatment.

Adolescent↗

PubMed1993

[Endoscopic wedge-shaped lung biopsy--initial experience].

The authors publish their initial experience with wedge-shaped pulmonary biopsy by the endoscopic route. The group is formed by 18 patients who were indicated for the operation on account of a disseminated pulmonary process in order to assess the micromorphological appearance of the affected lung tissue. Two patients developed a complication during operation which therefore was completed by minor thoracotomy. In who patients the authors observed after operation slow expansion of the pulmonary parenchyma. No death after the operation was recorded. The authors assume, based on their initial experience, that this operation will soon be included among common diagnostic operations and will help to facilitate the diagnosis and selection of treatment in patients with disseminated lung disease.

Adult↗