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Biomedical subjects

M Vejtorp

Publications and source records attributed to M Vejtorp.

17 recordsLinked to original sources
PubMed1992

[New therapeutic methods in tubal pregnancy].

A world-wide increase in the incidence of extrauterine pregnancy has increased interest in new forms of treatment of this condition. In Denmark, the number of cases of diagnosed tubal pregnancies has doubled from 1980 til 1989. Experience with the spontaneous course of tubal pregnancies is reviewed. In addition, various forms of laparoscopic treatment and systemic and local treatment with methotrexate are described. In Denmark, local treatment with prostaglandin has been employed with good effect. Whether conservative surgical treatment or treatment with methotrexate or prostaglandin are to be employed depends upon the patience of the treating physician as regards control examinations with ultrasonic scanning and measurement of serum human chorion gonadotropin. Repeated tubal pregnancy in the salpinx involved, persisting trophoblastic tissue after treatment and long periods of observation are unintentional side effects of treatment. After conservative treatment of tubal pregnancy, it is important that the patient is given meticulous information.

Female↗
PubMed1992

The secretory endometrial protein, placental protein 14, in women with ectopic gestation.

OBJECTIVE: To determine the serum level of the secretory endometrial protein, placental protein 14 (PP14) and progesterone (P) in women with ectopic gestation. DESIGN: Blood samples were collected prospectively and preoperatively. Reference range was determined from a prospective population of 98 women with uncomplicated pregnancies and normal outcome. SETTING: The women were admitted to a university hospital. PATIENTS: Fifty-nine women with laparoscopically verified ectopic pregnancy entered the study. INTERVENTION: At the time of diagnosis PP14 and P were measured. MAIN OUTCOME MEASURE: After observing the low serum levels of PP14 and P, a correlation analysis was made and compared with the findings in normally pregnant women. RESULTS: A significant positive correlation was found between the level of PP14 and P (P less than 0.00002), not found in normal intrauterine pregnancies. CONCLUSIONS: These findings suggest that the regulation of the PP14 production involves either a control mechanism from the ovary or is mediated by paracrine secretion.

Adult↗
PubMed1991

Treatment of tubal pregnancy by local injection of prostaglandin: selection of patients and evaluation of subsequent tubal patency.

Thirty women who had a small unruptured tubal pregnancy were treated by laparoscopically guided injection of prostaglandin F2 alpha into the oviduct and into the corpus luteum. They had no side effects. The serum human chorionic gonadotropin (S-HCG) concentration decreased in 25 women to less than 20 IU/l in a median time of 8 days (range 1-45). Five women were operated on because of increasing S-HCG concentration. The median diameter of the oviduct at the site of the gestation, the tubal localisation and the gestational age was similar in the women treated by prostaglandin and those, who were operated on after failure of the procedure. Four of the 6 women, with S-HCG concentrations of more than 2000 IU/l, needed subsequent operative treatment, compared to only one of 24 with a lower concentration. The median duration of the hospital stay after treatment was 2 days for the group of women with a S-HCG concentration of less than 2000 IU/l. Hysterosalpingography 3 months after treatment showed patency on the side of the pregnancy in 12 of 14 women. Prostaglandin injection seems to be an appealing option for the treatment of selected ectopic pregnancies.

Animals↗
PubMed1990

[Diagnosis and treatment of women with urinary incontinence at Danish gynecologic departments].

The routine practice in the diagnosis and treatment of urinary incontinence was investigated by means of a questionnaire to which all 32 departments replied. Miction charts were employed routinely in 17 departments and for selected patients in eight departments. Weighing of diapers was employed in 13 departments for all patients investigated for incontinence, but only for selected patients in ten departments. Cystometry was employed in cases of stress-incontinence in 23 departments and in cases of urge-incontinence in 30 departments. As regards the choice of operative treatment, 22 departments stated that they would employ abdominal intervention in cases of anterior suspension defect and vaginal operation in posterior suspension defects. Other departments perferred an abdominal or vaginal approach without employment of guiding miction cysto-urethrography. It is concluded that there are great differences in the routine practices in Danish gynaecological departments in the diagnosis and treatment of utinary incontinence. This appears to be a suitable field for so called reference programmes.

Denmark↗
PubMed1989

Local prostaglandin treatment of ectopic pregnancy.

Eleven women with small unruptured tubal pregnancies were treated by laparoscopically guided injection of prostaglandin F2 alpha in the oviduct and in the ovary which contained the corpus luteum. They had no side effects of the treatment and were discharged from hospital 1-3 days later. In 10 women the serum concentration of human chorionic gonadotrophin (HCG) decreased to less than 20 IU/l in a median time of 7.5 days, the range being 1-46 days. One woman required an operation 6 days after the treatment as her serum HCG level was stationary and she continued to have abdominal pain. Hysterosalpingography 3 months after the treatment showed patency of the oviduct on the side of the pregnancy in seven of the eight women who have been examined. We conclude that the injection of prostaglandin F2 alpha seems to promote the resolution of selected tubal pregnancies.

Chorionic Gonadotropin↗
PubMed1988

Bacterial vaginosis: a double-blind randomized trial of the effect of treatment of the sexual partner.

In a double-blind randomized controlled trial we assessed the effect of metronidazole treatment of the male partner on the recurrence rate of bacterial vaginosis. Women who fulfilled the diagnostic criteria for bacterial vaginosis were treated with metronidazole given in single doses of 2 g on days 1 and 3. The sexual partners were randomized to receive either the same dosage of metronidazole or a placebo. A total of 107 pairs completed the study. One week after the start of treatment 89% of the women considered themselves improved or cured and 93% no longer had the diagnostic criteria for bacterial vaginosis. At assessment 5 weeks after the treatment, 75% reported that they were cured or improved and the diagnostic criteria were not present in 73%. Treatment of the male partner did not affect subjective symptoms, clinical signs and isolation rates of Gardnerella vaginalis at 1 and 5 weeks after treatment.

Adolescent↗
PubMed1986

Serum lipoprotein changes in climacteric women induced by sequential therapy with natural estrogens and medroxy-progesterone acetate or norgestrel.

Thirty perimenopausal women were randomized to sequential therapy with either estradiol-valerate and norgestrel (Cyclo-Progynon), or estradiol and medroxy-progesterone acetate (EM 627). Blood samples were drawn before treatment and in the third treatment cycle during estrogen and progestogen phases respectively. The clinical effects of the two treatments were without significant difference. Ovulation was not suppressed by the treatments, which induced similar increases in serum estradiol and estrone concentrations. The medium serum high density lipoprotein-(HDL)-cholesterol concentration expressed as a percentage of the pretreatment level decreased in the postmenopausal women treated with Cyclo-Progynon to 90% compared with 104% (p less than 0.01) in the EM 627 group. However, the concentrations expressed in mmol/l did not differ significantly, probably owing to non-significant differences in the pretreatment levels. Low density lipoprotein-(LDL)-cholesterol concentrations decreased by approximately 10% in the postmenopausal women during both treatments. Cyclic addition of medroxy-progesterone acetate to estrogen replacement therapy does not adversely affect the serum lipoprotein pattern, and may be preferable to norgestrel.

Adult↗
PubMed1979

Diagnosis of postnatal rubella by the enzyme-linked immunosorbent assay for rubella IgM and IgG antibodies.

A semi-automated enzyme-linked immunosorbent assay (ELISA) was established for the detection of rubella IgM antibodies in non-fractionated sera. A cut-off level between rubella IgM positive and negative sera was determined by a study of sera without rheumatoid factor from 200 blood donors. Testing of 12 donor sera containing rheumatoid factor showed that 5 sera gave a positive result in the rubella IgM assay. Rubella IgM antibodies were quantified by ELISA in a study of 214 serial serum specimens drawn from 16 patients with rubella during a period of up to 10 years after the infection. Peak values of the IgM antibodies were reached approximately 8 days after onset of the rash, and the persistence of the IgM antibodies ranged from 17-90 days, with the exception of one patient with a prolonged IgM response. The rubella IgG antibodies increased slowly after the rash and reached maximum levels about 50-120 days, after which a monor decrease was observed. The results of the present study indicate that ELISA is suitable as a routine procedure for the serodiagnosis of recent rubella.

Acute Disease↗
PubMed1979

Enzyme-linked immunosorbent assay for determination of IgM rheumatoid factor.

A semi-automated enzyme-linked immunosorbent assay (ELISA) for determination of IgM rheumatoid factor was established. Human gammaglobulin (Cohn fraction II) was used as an antigen on a solid phase of polystyrene microtitre trays. The results were read on a spectrophotometer. ELISA and the sheep cell agglutination test were compared in a study of sera from 400 blood donors, 53 patients with active rheumatoid arthritis and of 200 sera received for routine determination of rheumatoid factor. The results of the two tests correlated well. The ELISA procedure was precise, objective, inexpensive and well suited for quantitative routine determination of IgM rheumatoid factor.

Adolescent↗
PubMed1978

Enzyme-linked immunosorbent assay for determination of rubella IgG antibodies.

A rubella virus antigen suited for enzyme-linked immunosorbent assay (ELISA) was grown in cultures of BHK/21/13 cells and purified and concentrated by membrane and ultrafiltration. This antigen was used in a semi-automated ELISA for determination of rubella IgG antibodies. The ELISA and the haemagglutination-inhibition (HI) test were compared in a study of 825 human sera. A close correlation was found between the results obtained by the two methods. Antibodies were, however, detected with ELISA in approximately 15% of the sera found negative in the HI test. The presence of antibodies was confirmed by the results of HI tests of the serum fractions of 19 sera separated by rate zonal ultracentrifugation. The EISA procedure employed in the present study was highly sensitive and allowed a precise quantitation of the antibodies by examination of one single serum dilution. ELISA was less time-consuming than the HI test and suited for routine laboratory use.

Antibodies, Viral↗
PubMed1977

Low concentration of plasma amino acids in newborn babies of diabetic mothers.

Plasma amino acid concentrations were measured in maternal peripheral vein and in umbilical vein and artery at birth (caesarean section) in 6 diabetic and 5 non-diabetic pregnancies. The mean birth weight in the control group amounted to 3.9 kg as oversize of the foetus in three cases contributed to the indication for caesarean section. The infants in the diabetic group consisted of "small for gestational age" babies (mean weight 2.8 kg). Free amino acid levels in the normal group and in diabetic maternal blood were in agreement with previous investigations. No difference in amino acid concentrations in the maternal plasma was found, but the concentrations of the umbilical vein plasma were significantly lower in the diabetic group. Foetal hyperinsulinaemia may be a cause of the low amino acid concentrations. Besides, abnormalities of the placenta and maternal vascular complications increase and the mean birth weights decrease significantly through the White classes. Conditions of impairment of placental transfer of amino aicds may thus be present. Characteristics features of the foetus may be consistent with the hypothesis as follows: The foetus in diabetic pregnancy is in varying degree exposed to an oversupply of glucose, hyperinsulinaemia, imbalanced uptake and a slightly diminished supply of amino acids.

Amino Acids↗