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Biomedical subjects

M Verhas

Publications and source records attributed to M Verhas.

At least 37 records · Page 2Linked to original sources
PubMed1985

Prognostic value of computed tomography in aphasic stroke patients.

In order to evaluate the prognostic value of CT scan in aphasic stroke patients, a prospective study was performed during the first 3 months of the disease. The severity of the language disorders was assessed by means of a quantitative method. In cortico-subcortical lesions, the verbal expression recovery rate and the final verbal expression and comprehension status depended on the infarct size. No relation was observed between the latter and the verbal comprehension recovery rate. In deep-seated lesions, computed tomography provided no information concerning the prognosis.

Aged↗
PubMed1984

Uptake of colloids by bone is dependent on bone blood flow.

In rat the uptake of colloids by the femur and tibia is dependent on bone plasma flow even if other factors modulate the relationship. We warn Nuclear Medicine scientists against the use of colloid uptake measurement as a marker of the bone macrophagic population, especially in situations associated with modified bone plasma flow.

Animals↗
PubMed1984

Resting CBF sequential study during recovery from aphasia due to ischemic stroke.

Cerebral blood flow (133Xenon inhalation method) has been studied in 30 aphasic stroke patients at 15, 30, 60 and 90 days after onset. In total aphasia the CBF values are low and the regional hypoperfused areas are extensive. In Broca's, Wernicke's and nominal aphasias, resting CBF measurements do not provide the clinician with useful additional information and clinical improvement can by no means be attributed to a resting CBF rise during the observation period.

Adult↗
PubMed1984

Growth and bone haemodynamic responses to castration in male rats. Reversibility by testosterone.

Orchidectomy in postpubertal 55 day old rats, compared to sham-operated controls, led beyond 2 months to a decrease in body weight (87% of controls by 120 d), tibial length (97% of controls) and in tibial calcium content (85% of controls). Bone plasma flow increased three times to reach a peak at 31 days; it was decreased but no significantly at 86 and 120 days. The number of osteoclasts was maximal at 51 days (X 2.3) and was still elevated at 120 days. The calcium accretion rate increased briefly at 31 days (110% of controls) and was diminished at 86 and 120 days (78% of controls). The initial 'physiological' changes in the tibia occurred before any weight change and might be directly due to the lack of androgens. They can be interpreted as inducing the conditions for enhanced bone resorption. Testosterone replacement therapy, initiated after the initial haemodynamic response, inhibited the negative effect of castration on bone growth.

Age Factors↗
PubMed1982

Effects of oxygen breathing on regional distribution of ventilation and perfusion in hypoxemic patients with chronic lung disease.

Regional distribution of ventilation and perfusion were measured in 17 hypoxemic and 16 normoxic patients using 13N as tracer. The effect of 100% and 50% O2 breathing was tested. No variation was observed in normoxic patients. In hypoxemic patients, perfusion was not modified significantly during O2 breathing. Poorly-ventilated zones hypoventilated even more during O2 breathing. It is suggested that this effect may have been due to (1) a collapse of some alveoli, (2) a variation in the mechanical properties of the surrounding opened alveoli, or (3) a possible modification in tidal volumes and functional residual capacities during O2 breathing.

Blood Gas Analysis↗
PubMed1982

[Transplantation of pediatric kidneys into adult patients (author's transl)].

Fourteen adult patients were transplanted with a single pediatric kidney and were followed for 26 days to 9 years. Donor ages ranged from 22 months to 10 years, recipient ages from 15 to 47 years. Ten transplants functioned for more than one year. Three kidneys were rejected after 26 days, 3 months and 18 months. Three patients died 2, 6 and 13 months after transplantation from aspergillosis, cytomegalovirus infection and salmonellosis. Eight kidney grafts are currently functioning 2 to 9 years after transplantation. Serum creatinin levels range between 0.9 and 1.1 mg/dl in 7 patients. One woman with chronic rejection has a serum creatinin level of 2.5 mg/dl. A single pediatric kidney is able to sustain a satisfactory renal function in an adult recipient.

Adult↗
PubMed1981

Transplantation of both kidneys of an anencephalic newborn to a 23-year-old patient.

Both kidneys of an anencephalic newborn were transplanted into a 23-year-old male patient. Hemodialysis was required for 3 weeks postoperatively. Both organs increased in size but did not reach the normal volume of an adult kidney. 3 years post-transplantation, the patient is doing well with a plasma creatinine level of 1.5 mg/dl. Technical problems are discussed.

Adult↗
PubMed1979

Simple, fast preparation of gallium-68-labelled human serum albumin microspheres.

Following a study of the main factors involved in the 68-Ga labelling of human serum albumin microspheres (H.S.A.M.), especially methods of production and preparation of active solution and conditions of radioelement fixation on the protein support, the practical details of a fast technique (60 min) based on the process described by Hnatowich are presented. This method gives high labelling yields (93 +/- 3%), and after washing of the microspheres leads to a radiopharmaceutical product almost without free 68Ga (less than 2%). The spheres ready for use carry a total radioactivity corresponding to about 35%, including decay, of the activity originally recovered in the generator eluate and to more than 98% of that, found in the final suspension. The labelled product is sterile, non-pyrogenic and non-toxic. When it is injected in animals by left ventrical catheterization the uptake rates in the heart, lungs, spleen, left kidney and right kidney are similar to those observed with reference 85Sr-labelled carbonized microspheres. This radiopharmaceutical, easy to prepare and having excellent biological and nuclear properties, seems ideally suited for the scanning of organs by position emission tomoscintigraphy.

Animals↗
PubMed1979

Brain distribution and kinetics of 11C-chlorpromazine in schizophrenics: positron emission tomography studies.

The positron emitter 11C (20 minutes half-life) permits the labeling of chlorpromazine (CPZ) and the study of its distribution in humans by external counting. Trace amounts of 11C-CPZ were injected intravenously into 22 schizophrenic patients all untreated for several months with neuroleptics. The brain uptake was 6.04 +/- 1.6% of the injected dose 15 minutes after the injection, and it remained constant for 45 minutes. By positron emission tomography, the drug distribution was shown to be in the gray matter, and such structures as the cortex, caudate nucleus, thalamus and putamen could be identified. This new methodology will be helpful in studying specific receptors in humans in a noninvasive way.

Adolescent↗