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Biomedical subjects

M Verini

Publications and source records attributed to M Verini.

At least 19 recordsLinked to original sources
PubMed2001

Sensitization to environmental antigens in asthmatic children from a central Italian area.

This study was designed to evaluate the frequency of respiratory allergens in different age groups of asthmatic atopic children in the Chieti-Pescara area. We examined a pediatric population (507 children) aged between 1 to 17 years (mean 6.62 +/- 2.9). All the children were submitted to a panel of skin prick tests (SPT) for 12 common aeroallergens: Grass Pollens (G.), Parietaria (P.), Olive (O.), Artemisia (A.), Ragweed (R.), Dermatophagoides Pteronyssinus and Dermatophagoides Farinae (D.P. & D.F.), Cat and Dog dander (C.D.), Feathers (F.), Alternaria (Al.), Aspergillus (As.). All the subjects gave positive result to one or more allergens. The population was subdivided in to 4 groups according to their age (Group A: 1-3 years; Group B: 4-6 years; Group C: 7-9 years; Group D: 10-17 years). In each age group, we determined the number of subjects with 1, 2, 3, 4 or 5 and more than 5 positive SPT and the prevalence of positive SPT for different allergens. We found that 74% of 507 patients showed positive reaction to Dermatophagoides Pt, 71% to Dermatophagoides Fa, 45% to Grass, 23% to Parietaria, 21% to Olive, 17% to Artemisia, 17% to Cat's or Dog's danders, 13% to Alternaria, 5.9% to Ragweed, 5.9% to Feathers, and 4% to Aspergillus. In addition we detected that 12% of children examined were monosensitized; 56% were sensitized to 2 or 3 allergens; 22% were sensitized to 4 or 5 allergens, and then 8% were polysensitized to > 5 allergens. The allergy to grass pollens and to house dust mites was the most frequent in monosensitized. In the older patients, we found an increase in number of positives SPT to several allergens, and an increase in the frequency of Gr., P. and O. allergy, while the house dust mites sensitization remained constant in all groups and represented the dominant cause of asthmatic symptoms in this population. Our data confirm the importance of age in determining a respiratory polysensitization. In conclusion, our data suggest that house dust mites (D.P. and D.F.) and grass pollens are the most common allergens in asthmatic children of the Chieti-Pescara area.

Adolescent↗
PubMed1995

Effectiveness of nedocromil sodium in preventing exercise-induced asthma in children.

Exercise-induced asthma is a well-known phenomenon, particularly affecting children, with an important social impact. In order to assess the usefulness of nedocromil sodium in the prevention of exercise-induced asthma, we studied 49 (15 females, 34 males) children who suffered from asthma; their mean +/- SD age was 9.2 +/- 3.0 (range: 3.3-19.1) years. On the first day respiratory function was evaluated by spirometry, basally and after 6 minutes. The inhalation of nedocromil sodium had a great influence on post-exercise lung function measurements; in fact on the day of nedocromil sodium pretreatment, our patients showed an increase of respiratory function, significantly different from the parameters recorded during the first day. Our findings suggest that nedocromil sodium is effective in the prevention of exercise-induced asthma, in pediatric age.

Adolescent↗
PubMed1990

Long-term therapy in childhood asthma: clinical and auxological effects.

The authors studied the effect of different therapeutical regimens on the growth of children suffering from asthma. These patients were subdivided into four groups of ten patients according to their therapeutic regimens: Group A = ketotifene (1 mg, two times/day), Group B = diproprionate beclomethasone + salbuthamol (100 + 200 mcg, 3 times/day), Group C = ketotifene + diproprionate beclomethasone, Group D = disodiumcromoglycate (20 mg, 3 times/day). The patients were followed for at least 1 year. Our study has shown that all the children treated with the four different regimens had a normal growth and growth velocity.

Adolescent↗
PubMed1989

IgG subclass deficiency and recurrent respiratory infections in children.

The aim of this study was to investigate the humoral immunity of children with recurrent respiratory tract infections. Fifty-seven (17 female, 40 male) children, aged from 1.1 to 12.0 years were evaluated, after 1 month from the last infectious disease. The total number of children with IgG subclasses deficiency was 29/57 with the following IgG deficiency distribution: IgG1 = 2 children, IgG2 = 13 children, IgG3 = 4 children, IgG4 = 25 children. Moreover, 13 children with IgG4 deficiency showed low levels of other (one or more) IgG subclasses. It is probable that these low IgG subclasses levels are an important immunological abnormality of these children.

Child↗
PubMed1986

[Chernobyl accident: dosimetric evaluation and estimation of risks].

The results of dosimetric evaluations carried out after Chernobyl accident in the Health Physics Department of Niguarda Ca' Granda Hospital (Milan) on air, rain and ground contamination are presented. The results obtained show that the incidence of stochastic late effects, both somatic and genetic, will be so low that practically will not be distinguishable from "natural" incidence.

Accidents↗
PubMed1985

Evaluation of reproterol's effectiveness in preventing exercise-induced bronchospasm in children.

The authors have evaluated the effectiveness of the protection of a new beta 2-adrenergic compound, reproterol, against broncho-constriction induced by physical exercise in a group of individuals of paediatric age sensitive to broncho-stimulation. This study has been carried out comparing reproterol with salbutamol, using placebo as a control, following a randomized single-blind crossover trial. The provocation test has been performed following the instructions of the Italian Society of Paediatrics. The drugs have been administered in the oral liquid form at the dose of 0.28 mg/kg and 0.1 mg/kg of reproterol and salbutamol, respectively. The two substances have shown a similar preventive effectiveness in controlling exercise-induced asthma up to 2 hours from administration with reproterol having a stronger action at the beginning of the observation.

Adrenergic beta-Agonists↗
PubMedDate not supplied

Pulmonary function in diabetic children with and without persistent microalbuminuria.

The principal spirometric and plethysmographic parameters were measured in 68 (38 female) diabetic children and adolescents, aged from 6.01 to 22.00 years; their duration of disease ranged from 1 to 247 months. Thirty-four patients had persistent microalbuminuria. The patients were studied basally and after the Bruce test. All the spirometric parameters were normal in all children, with and without microalbuminuria. The presence of microalbuminuria seems not to be a risk factor for the developing of abnormal pulmonary function.

Adolescent↗
PubMedDate not supplied

Lack of correlation between clinical patterns of asthma and airway obstruction.

To evaluate the relationship between the classification of asthma and obstruction of airways, we have studied 100 children suffering from allergic asthma: 65 males and 35 females, aged 4.2-16.3 years (mean, 7.6 +/- 2.8 years), who were evaluated at least 1 month after the last attack of airway obstruction. We analyzed personal history of all children with special reference to number of attacks of airway obstruction in the last year, severity, and presence of respiratory symptoms in the last month. The children studied have been classified in three groups according to the International Pediatric Respiratory Allergy Forum (IPRAF) '98 method (Third International Pediatric Consensus Statement on the management of childhood asthma). All children underwent the assessment of their respiratory function by means of analysis of the flow/volume loops with measurement of the obstruction indices (forced expiratory volume in 1 second [FEV1], peak expiratory flow [PEF], and maximal midexpiratory flow [MMEF]). The efficacy of the aforementioned method has been evaluated by analyzing the number of the subjects who showed indices of airway obstruction not in agreement with the group assigned. Eighty-five of the children studied were diagnosed with infrequent episodic asthma (IEA), 14 children were diagnosed with frequent episodic asthma (FEA), and 1 child was diagnosed with persistent asthma (PA). Thirty-six of 100 children showed obstruction indices not in agreement with the asthma group: in particular, 24 of 85 children with IEA had FEV1 < 80%, 11 children with FEA had FEV1 > 80%, and 1 child with PA had FEV1 > 80%. The high percentage of discordance between clinical classification and obstruction index in the subjects with IEA can be caused by the persistence of abnormalities of the respiratory function without clinical symptoms. The presence of a normal obstruction index in the subjects with FEA can be explained by the pharmacologic therapies. These data suggest the usefulness of a careful evaluation of the respiratory function associated with a clinical assessment to carry out a more appropriate therapy.

Adolescent↗
PubMedDate not supplied

[Evaluation of nasal eosinophils after specific provocation in the diagnosis of respiratory allergy].

The authors describe the results of a study of a group of children suffering from allergic rhinitis; the Authors evaluated eosinophils, basally and after nasal provocation test. Both clinical and cellular responses were evaluated. The basal results were: presence of eosinophils in 9/17 (52.9%) subjects allergic to Graminacee, in 42/61 (68.3%) subjects allergic to Dermatophagoides and in 3/3 (100%) subjects allergic to Parietaria. The results of the clinical response are the following: Graminacee: positive response in 20/22 (90.9%) tests; Dermatophagoides: 48/63 (76.2%); Parietaria: 6/6 (100%). The results of laboratory response are the following: Graminacee: positive response in 14/18 (77.8%) tests; Dermatophagoides: 45/59 (76.3%); Parietaria: 5/5 (100%). The evaluation of both responses is useful to increase the sensitivity of the nasal provocation test.

Adolescent↗
PubMedDate not supplied

[Clinical and functional sequelae of bronchiolitis].

The authors carried out a follow-up on twenty-five children, affected with bronchiolitis in the early years of life, at seven years of age, in order to evaluate their clinical status and pulmonary function. Their parents were questioned about diseases of the small airways following to acute bronchiolitis. PRIST and RAST were effected in fourteen children; an evaluation of the pulmonary function with spirometry, flow-volume curve and body-plethysmography was done in every child. Then the flow-volume curve was repeated after bronchial provocation test with exercise (free running). Abnormalities of the pulmonary function at resting significant for small airways' obstruction were observed. A great number of children with bronchial hyperreactivity (60%) was observed after bronchial provocation test with exercise, particularly in those with genetic predisposition; 6/14 (43%) showed sensitization to many inhalant allergens, without correlation with genetic predisposition, clinical sequences and bronchial hyperreactivity.

Airway Resistance↗
PubMedDate not supplied

[Pharmacological prevention of exercise-induced bronchospasm: review of the literature and trial of disodium cromoglycate, fenoterol and ipratropium bromide in a pediatric population].

Exercise-induced bronchospasm (EIB) is an instrumentally-measurable paraphysiologic phenomenon, related to bronchial hyperreactivity in asthmatic children. Therefore EIB is very useful to evaluate airways hyperreactivity and pharmacological treatment in asthmatic child. We have evaluate EIB inhibition and bronchodilator effect of three drugs: Disodiumcromoglycate (DSCG), Fenoterol (F), Ipratropium Bromide (IB), in a group of 27 asymptomatic and therapy-free asthmatic children. The bronchial provocation test was performed by physical exercise (free-running for six minutes) according to criteria stated by Paediatric Bronchopneumology Group of S.I.P. Therefore we have analysed the most recent studies to correlate our results with other's data: our study confirm DSCG and Beta-adrenergic drugs effectiveness; theophylline has a similar validity, but is less useful in clinical practice; anticholinergic drugs and corticosteroids seem less valid; the new drugs (Ketotifen, alpha-blockers and calcium antagonists) need further controlled studies.

Adolescent↗
PubMedDate not supplied

[Study of somatosensory evoked potentials in full-term and premature neonates].

The electrophysiological maturation of both peripheral and 'central' (spinal + superspinal) nervous fibers belonging to peroneal and medial nerves was evaluated within the 1st month of extrauterine life. Thirty-five newborns with different gestational ages (15 FT, 20 PT), have been examined through the SEP technique during percutaneous stimulation of median (wrist and index finger) and peroneal (popliteal fossa) nerves. Recording electrodes were placed at Erb's point, lumbar and cervical spine, scalp sites corresponding to the sensory areas for upper and lower limb. Peripheral conduction velocities were correlated with chronological ages but they did not correlate neither with gestational ages nor with birth weightes. Central conduction velocities correlated with gestational ages. The role of maturation was faster for the former than for the latter.

Evoked Potentials, Somatosensory↗