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Biomedical subjects

M Verlinden

Publications and source records attributed to M Verlinden.

At least 37 records · Page 2Linked to original sources
PubMed1993

A double-blind fluoroscopic study of cisapride on gastrointestinal motility in patients with functional dyspepsia.

Twenty patients with functional dyspepsia were referred for radiologic examination and, upon confirmation of a hypomotile stomach, were given either 10 mg cisapride or placebo in a double-blind manner (10 patients per group). The movement of a 250-ml barium meal was assessed by means of television fluoroscopy performed at regular time intervals. Cisapride significantly improved antral contractility and enhanced gastric emptying compared with placebo. Deep peristaltic waves occurred over the entire small bowel, and motility and small-bowel transit time of the barium meal were significantly increased in the cisapride group compared with the placebo group. The study demonstrates that when a carefully defined protocol is observed, fluoroscopy following barium ingestion offers considerable potential in the assessment of gastrointestinal motility.

Barium Sulfate↗
PubMed1989

Gastroesophageal reflux incidence and respiratory dysfunction during sleep in infants: treatment with cisapride.

We studied the effects of positional treatment and cisapride (a new prokinetic agent) on the incidence and duration of gastroesophageal reflux in 22 infants (4-26 weeks old) in asleep, awake, fasted, and postcibal periods. In addition to gastroesophageal reflux (assessed by 24-h continuous esophageal pH monitoring), all infants presented with a disrupted irregular sleep pattern ("respiratory dysfunction") (assessed by a simultaneously performed cardiopneumogram). Reflux was particularly prominent during the sleep and fasted periods. Investigations (cardiopneumogram and esophageal pH monitoring) in the study population were repeated under treatment conditions (cisapride) after 13-16 days. All pH monitoring data with regard to the total investigation time decreased significantly (p less than 0.001). The treatment-related differences were largest in the asleep and fasted periods, but treatment data were not completely within normal ranges (established in age-matched asymptomatic infants), as they were for the awake periods. Associated symptoms of gastroesophageal reflux (belching, cough, nocturnal wheezing, irritability, and restlessness at night) were evaluated before and during treatment by history. A combination of positional treatment and cisapride seemed effective (objectivated by pH monitoring data and clinical improvement); cisapride did not cause adverse reactions. The disrupted sleep pattern improved significantly or disappeared (p less than 0.001) in all infants. These data suggest that in a number of young infants, gastroesophageal reflux may be associated with a disturbed, irregular sleep of poor quality, which is characterized by a typical breathing pattern (multiple, irregularly repeated, short apneas).

Cisapride↗
PubMed1989

Review article: a role for gastrointestinal prokinetic agents in the treatment of reflux oesophagitis?

Gastro-oesophageal reflux disease may result from a host of factors. Medical therapy has largely been aimed at neutralizing acid or decreasing acid production but improvement of upper-gastrointestinal motility may prove to be a valuable treatment modality as well. This paper reviews the current state of knowledge of the pathogenesis of reflux disease and concentrates upon promotility treatment with domperidone, metoclopramide and cisapride.

Animals↗
PubMed1989

Perinatal mortality in Belgium.

Perinatal mortality in Belgium remains high compared with other countries of Western Europe, although a marked decrease was observed during the period from 1956 to 1984. Analysis of the death causes indicates that further progress is feasible. Social inequalities and geographic variation are persisting in spite of the long-established policy of social welfare and free access to health services. Most of the studies on perinatal mortality in Belgium are descriptive and based on data recorded in birth and infant death certificates. In the future, alternative sources of information should be used to analyze more precisely and to understand more clearly the interactions between the different determinants of perinatal mortality and to evaluate the impact of social and health services.

Belgium↗
PubMed1988

Treatment with cisapride of the gastrointestinal and urological sequelae of spinal cord transection: case report.

We describe the case of a paraplegic patient who suffered traumatic spinal cord injury at the level of the twelfth thoracic vertebra. Within a short period of time following the injury, urinary (neuropathic bladder) and gastrointestinal (atomic colon) sequelae arose. Treatment with Cisapride (R 51 619, Janssen Pharmaceutica) was undertaken in an attempt to increase colonic motility and to reduce urinary retention. These goals were reached rapidly with a dose of 10 mg q.i.d.; the effect has been maintained for at least 18 months since starting the therapy.

Bisacodyl↗
PubMed1988

Effect of cisapride on the post-cholecystectomy upper gastrointestinal transit time.

For the evaluation of postoperative upper gastrointestinal transit, the breath hydrogen test is a convenient method, which is simple but more reliable than the recording of clinical parameters such as bowel sounds. The test was used to study the effect of cisapride on the postoperative mouth-to-caecum transit time. Twenty patients undergoing cholecystectomy were tested pre-operatively and on the first postoperative day after having received either 10 mg of cisapride i.v. or matching placebo under double-blind conditions. The median preoperative transit time in the placebo group was 45 min, and the median postoperative transit time at least 3 h longer. The postoperative transit time after cisapride dosing was still longer than before the operation but was significantly (p = 0.02) reduced as compared with that after placebo administration.

Adult↗
PubMed1987

Treatment of postoperative gastrointestinal atony.

One hundred and eighteen patients in whom postoperative gastrointestinal atony had lasted for 48-72 hours, were given one or two intravenous injections of different doses of cisapride (2, 4 or 8 mg), or vehicle. The first occurrence of flatus was taken to mark the cessation of ileus. There was no significant difference in remission of ileus between the groups in the first hour following injection. All patients not responding to treatment in the first hour were given a repeat dosage and observed for the following 3 hours. Among this group, there was a significant remission of ileus in patients who had received 2 X 8 mg, which was particularly marked in those who had undergone intraperitoneal surgery. This study suggests that cisapride in repeated dosage may be of value in inducing remission in prolonged surgical ileus, particularly in patients who have undergone intraperitoneal operations.

Cisapride↗
PubMed1987

Placebo-controlled trial of cisapride in postoperative ileus.

The effect of 4 mg of the gastrointestinal motility enhancing agent cisapride on postoperative ileus was compared with that of a placebo in 53 patients who had undergone various types of surgery. They received one i.v. injection of the double-blind medication, or two if no distinct flatus occurred within an hour after the first injection. The placebo response was very limited; borborygmi or flatus did not occur in more than 12% of the patients not even after the second injection. Cisapride was significantly effective: bowel sounds were present in 43% and 50% within 1 hour after the first and second injection of 4 mg, respectively, and flatus in 36% and 43%. The recognition that colon inactivity probably is the major determinant of the ileus, may be indicative of a substantial relative impact of cisapride's stimulating effects on colon motility.

Adult↗
PubMed1986

[Neonatal mortality and birth weight. Which strategy for the future?].

In this study the authors analysed the neonatal mortality rates in Belgium in 1981 and 1982. Newborns were grouped into four categories according to their birth weight: 500-1,499 gr (Cat. A), 1,500-2,499 gr (Cat B), 2,500-3,499 gr (Cat C), 3,500 gr or more (Cat D). The distribution of neonatal deaths in those four categories was 33.2% in category A, 29% in category B, 27.3% in category C and 10% in category D. A specific strategy to lower neonatal mortality in each category could be worked out. The authors analysed what priority should be given to each category according to the data found in the literature concerning the following criteria: effectiveness, cost and doing the least damages. They concluded that the present focus on category A, is over done and should not be the strategy to be used at present. The higher neonatal mortality of newborns of category C (2,500-3,499 gr) as compared with the neonatal mortality in category D (3,500 gr and more) is generally underestimated and underanalysed. Reducing this extra mortality could result in lowering Belgium neonatal mortality by 12%. The organisation and accessibility of obstetric care seem to be linked to this higher mortality. In their conclusions the authors suggest other studies and short-term objectives that should be considered in order to lead to a continued lowering in neonatal mortality.

Belgium↗
PubMed1984

Bradycardia, ventricular pauses, syncope, and sports.

16 athletic patients were examined because of syncope, Stokes-Adams attacks, or both. The life-threatening condition required pacemaker implantation in 7 patients. 8 of the 9 other subjects became symptom-free after stopping heavy physical training. 37 top-ranking athletes underwent 24 h Holter monitoring. Pauses longer than 2 s occurred in 19% and resulted from sinus arrest. The longest pause lasted 2.5 s. Second-degree atrioventricular block was noted in 13%.

Adams-Stokes Syndrome↗
PubMed1984

Cisapride accelerates gastric emptying and mouth-to-caecum transit of a barium meal.

Cisapride (R 51 619) is a newly synthesized compound, which facilitates the release of acetylcholine in the myenteric plexus of the gut. Its effect on gastric emptying of a barium meal was evaluated in 84 patients under randomized, double-blind conditions. Two oral doses (5 mg and 10 mg) of cisapride were compared with a placebo, and two intravenous doses (4 mg and 8 mg) with a placebo and with 10 mg metoclopramide. All doses of cisapride and metoclopramide were significantly superior to placebo in accelerating gastric emptying, intensifying antral contractions and shortening the mouth-to-caecum transit time. The effects of 8 mg cisapride and 10 mg metoclopramide given intravenously were comparable.

Adolescent↗