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Biomedical subjects

M Veronese

Publications and source records attributed to M Veronese.

At least 19 recordsLinked to original sources
PubMed2005

Spin-flop ordering from frustrated ferro- and antiferromagnetic interactions: a combined theoretical and experimental study of a Mn/Fe(100) monolayer.

The occurrence of a noncollinear magnetic structure at a Mn monolayer grown epitaxially on Fe(100) is predicted theoretically, using spinor density-functional theory, and observed experimentally, using x-ray magnetic circular dichroism (XMCD) and linear dichroism (XMLD) spectroscopies. The combined use of XMCD and XMLD at the Mn-absorption edge allows us to assess the existence of ferromagnetic and antiferromagnetic order at the interface, and also to determine the moment orientations with element specificity. The experimental results thus obtained are in excellent agreement with the magnetic structure determined theoretically.

Journal Article↗
PubMed2003

Giant magnetic anisotropy of single cobalt atoms and nanoparticles.

The isotropic magnetic moment of a free atom is shown to develop giant magnetic anisotropy energy due to symmetry reduction at an atomically ordered surface. Single cobalt atoms deposited onto platinum (111) are found to have a magnetic anisotropy energy of 9 millielectron volts per atom arising from the combination of unquenched orbital moments (1.1 Bohr magnetons) and strong spin-orbit coupling induced by the platinum substrate. By assembling cobalt nanoparticles containing up to 40 atoms, the magnetic anisotropy energy is further shown to be dependent on single-atom coordination changes. These results confirm theoretical predictions and are of fundamental value to understanding how magnetic anisotropy develops in finite-sized magnetic particles.

Journal Article↗
PubMed1989

Ultrastructural findings of Candida albicans blastoconidia submitted to the action of fenticonazole.

A study has been conducted about ultrastructural changes induced by an imidazole derivative, fenticonazole (Lomexin), on Candida albicans blastoconidia. The structural upset has been progressively exerted starting from coating membrane surfaces throughout cytosol components and nuclear compart, so that the existence can be assumed for a direct dependence of these changes upon activity failure by a few organules. Membrane permeability processes have resulted to be involved, which are the main metabolic paths in the defective ATP synthesis, and enzyme blockades responsible for peroxide accumulation.

Antifungal Agents↗
PubMed1987

[Quinolizidine derivatives with antimicrobial activity].

Thirty quinolizidinyl derivatives, together with two dialkylaminoalkyl analogues, were tested at concentration up to 160 mg/l for antimicrobial activity against 17 microrganisms, including gram-positive and gram-negative strains, Mycobac, tuberculosis, Trichom, vaginalis, fungi and yeasts. The most common activity found is that against Mycobac, tuberculosis, followed by that against gram-positive strains; several compounds [(I a), (I b), (I c), (II a), (III a), (VIII e), (XIX e), (XXI e)] exhibit a good or a very high level of activity. Concerning the gram-negative bacteria, activity is found only against Escherichia coli and is random and usually slight, as is that against fungi, yeasts and protozoa. Compounds (I a), (III a) and (XXI e) are of interest for their high activity and for their broad spectrum of activity, while compound (X e) is peculiar for its selectivity against Mycobac. tuberculosis.

Anti-Bacterial Agents↗
PubMed1987

Experimental studies in vitro and in vivo on the mutagenicity of flavoxate.

Flavoxate HCl is a drug with a remarkable smooth muscle relaxant activity, selective for the genito-urinary tract. In order to verify its safety the following mutagenic tests have been effected: gene reversion in S. typhimurium, gene conversion and crossing-over on S. cerevisiae 6117, micronucleus test and DNA-repair on B. subtilis. In our experimental conditions, flavoxate HCl was found to be devoid of potential mutagenic activity.

Animals↗
PubMed1985

The quantitative determination of neomycin sulphate by a diffusion technique on agar plates by the method of the European Pharmacopoeia, 2nd edition--evaluation of precision and reproducibility of the method.

The medium recommended by the European Pharmacopoeia (EP), 2nd edition, for the microbiological determination of neomycin by the agar diffusion method was tested and compared with the medium recommended by the EP, 1st edition. The tests were carried out in different laboratories. The medium recommended by the EP, 2nd edition, gave greater precision and reproducibility than the previous medium. The possibility of using a reference standard of almost pure neomycin B for both the determination of framycetin and neomycin was evaluated. The results demonstrated that the medium recommended by the EP, 2nd edition, gave better precision and reproducibility. Difficulty in achieving valid assays was practically the same with both media.

Bacillus subtilis↗
PubMed1985

Mutagenicity studies on denzimol, a new anticonvulsant drug.

N-[beta-[4-(beta-Phenylethyl)phenyl]-beta-hydroxyethyl] imidazole hydrochloride (denzimol, Rec 15-1533), a new anticonvulsant drug, was tested using the Ames procedures with and without metabolic activation, on five strains of Salmonella tythimurium and using the host mediated assay with Schizosaccharomyces pombe as microorganism test. In both tests the drug did not show any mutagenic activity when compared with mutagenic standards.

Animals↗
PubMed1983

Mutagenicity studies on tibezonium, a new oropharyngeal disinfectant.

N,N-Diethyl-N-methyl-[2-[[4-(4-phenylthio) phenyl]-3H-1,5-benzodiazepin-2-yl]thio]-ethanaminium iodide) (tibezonium iodide; CAS-54663-47-7), a new oropharyngeal disinfectant, was tested, using the Ames procedure with and without metabolic activation, on five strains of Salmonella typhimurium and using the host mediated assay with Schizosaccharomyces pombe as microorganism test. In both tests the drug did not show any mutagenic activity when compared with mutagenic standards.

Animals↗