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M Visy

Publications and source records attributed to M Visy.

At least 19 recordsLinked to original sources
PubMed1989

[Long-term follow up of chronic recurrent isolated hematuria].

A retrospective multicentre study of 341 children with persistent/recurrent, isolated haematuria is described. The haematuria was isolated for at least half a year in the beginning of observation. 47.8% of the patients became symptom-free. In 18.4% the haematuria remained isolated, in 13.8% it was combined with greater than 250 mg/day proteinuria greater than 2 years later. The occurrence of associated proteinuria was 8.6% between the 3rd to fifth years, and 37.0% after the 5th years. 14 cases had Alport's nephropathy. The percentage of more serious azotaemia was 1.7 (Ccreat: 10-50 ml/min/1.73 m2) and 0.3 (Ccreat: less than 10 ml/min/1.73 m2). Mortality was 0.58%, rate of hypertension 1.2%. Most of the patients who developed severe azotaemia, had persistent microscopic haematuria in the beginning. The haematuria was associated with hypercalciuria in 19.9%. In 14.3% of the overall group of patients urolithiasis developed 2-15 years after onset. All of them had hypercalciuria. Our findings suggest that symptoms of isolated haematuria may last for a long-term period and need systematic control. When proteinuria and/or hypertension associates to haematuria a worse prognosis can be expected.

Child↗
PubMed1989

Long-term follow-up of patients with persistent/recurrent, isolated haematuria: a Hungarian multicentre study.

A retrospective multicentre study of 341 children with persistent/recurrent, isolated haematuria is described. The haematuria was isolated for at least 6 months at the beginning of observation. The duration of follow-up was 2-5 years in 201, 5-10 years in 119, 10-15 years in 19, and over 15 years in 2 cases. Of these patients 47.8% became symptom-free. In 18.4% the haematuria remained isolated; in 13.8% it was combined with proteinuria over 250 mg/day more than 2 years later. The occurrence of associated proteinuria increased progressively with time. It was 8.6% between the 3rd and 5th years, and 37.0% after the 5th year. Renal biopsy was performed because of the symptoms of glomerular disease in 47 cases at an average time of 12 months following the appearance of proteinuria. Proteinuria appeared after a 2-5, 5-10, 10-15 and more than 15 years follow-up period in 16, 23, 6, and 2 patients respectively; 14 of them had Alport's nephropathy. The percentage of more serious azotaemia was 1.7 (creatinine clearance: 10-50 ml/min per 1.73 m2) and 0.3 (creatinine clearance: less than 10 ml/min per 1.73 m2). Mortality was 0.58%. Most of the patients who developed severe azotaemia had persistent microscopic haematuria at the beginning. The prevalence of hypertension was only 1.2%. The time of its appearance was above 5 years in 2 and below 5 years in 2 cases. All these patients had chronic glomerulonephritis. The haematuria was associated with hypercalciuria in 19.9%. In 14.3% of the overall group of patients urolithiasis developed 2-15 years after onset. All of these had hypercalciuria.(ABSTRACT TRUNCATED AT 250 WORDS)

Child↗
PubMed1987

Renal function in normal and kidney traumatized germfree rats.

A comparative study was made between kidney-traumatized (unilateral nephrectomy, contralateral ligation of renal artery, and release after 120 min) germfree (GF) and conventional (CONV) rats, and normal control GF and CONV rats. In the kidney-traumatized animals the following trends were indicated. (i) Deaths in 3 to 5 days occurred approximately 25% of the time in GF and 60% in the CONV groups. (ii) Two to 4 days post-operation the renal blood flow was essentially unchanged in GF in comparison to normal controls, while it was 30% of the normal values in CONV rats. (iii) Blood urea nitrogen was approximately 4 times the normal values in GF and 28 times in CONV animals. (iv) The ratio of urine and blood plasma osmolality indicated that the concentrating ability of the kidneys was well maintained in GF while it was virtually lost in CONV traumatized rats. (v) The clearance of intravenously administered, labelled thiourea into the urine and caecal lumen of GF rats was markedly elevated in comparison to the low clearance of this label in CONV rats. No essential differences in kidney function were noted among normal (unoperated or sham-operated) GF and CONV groups. The results indicate that the absence of the intestinal flora is advantageous to the host. This effect might be caused by relief from microbial burden and by the enlarged caecum of GF rats acting as an auxiliary "dialysis membrane". Based on these data the role of oral antibiotic treatment in the management of human uraemia is worth investigating.

Animals↗