Haemopoietic defects in mice infected with lymphocytic choriomeningitis virus. 2. The viral effect upon the function of colony-forming stem cells.
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Biomedical subjects
Publications and source records attributed to M Volkert.
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The hypothesis that treatment with antilymphocytic serum (ALS) can provoke latent virus infections has been investigated. In adult mice infections with sublethal doses of LCM virus usually result in the development of immunity to the virus and at the same time to a prolonged latent infection. In the experiments described an intensive treatment with large doses of ALS was given to mice which had recovered from LCM virus infection. At the beginning of the treatment the mice had high titers of complement-fixing antibodies in their blood and no detectable virus. The data presented show that in spite of the immunity the ALS treatment provoked the occult virus and led to the development of viremia in all the treated mice. In some, very high virus titers were demonstrable. When the ALS treatment was discontinued the viremia disappeard again. In most of the mice the ALS did not suppress the complement-fixing antibody titers and in some there was even a considerable increase in titer. In such cases the increases in virus titers and in antibody titers were closely related to one another. These results demonstrate once again that the complement-fixing antibodies to the LCM virus in mice probably do not influence the virus.
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Old people's living conditions and their quality of life are described in respect to demographic aspects, family income, wealth--as well as housing conditions, based on official data and a West Germany Welfare Survey carried out in 1978. In addition to these "objective" conditions is analyzed, how old people perceive their quality of life in different areas, i.e. concerning their satisfaction, their anxieties and sorrows, their social relations. It can be shown that the relatively moderate aspiration-level of old people is important to explain their satisfaction. In contrast to concepts which regard old people as a burden is emphasized, that old people bring forth material, social and emotional help for others.