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Biomedical subjects

M Vona

Publications and source records attributed to M Vona.

9 recordsLinked to original sources

[Value and limitations of sport in cardiac patients].

Regular physical exercise increases effort capacity, the quality of life, and improves symptoms in all cardiac patients. In addition, and much more importantly, all studies show a close correlation between exercise and the reduction of mortality and morbidity with a beneficial effect on the progression of atherosclerosis. This relationship is particularly well documented in patients with coronary artery disease. Exercise has a beneficial effect due to its action on all the principal coronary risk factors, an endothelial dysfunction, coagulability and prevention of thrombosis and an autonomic nervous system tone. All forms of physical activity and some sports may therefore be considered by these patients. In some cases, competitive sport may be permitted, in accordance with popular social custom. In order to obtain these cardiocirculatory protection, physical exercise and sporting activities should be the object of a personalised therapeutic prescription which takes into account the intensity, the type of effort, its duration and frequency. Indeed, if the intensity of the exercise is too low, these patients may not obtain the desired benefits. On the other hand, excessively intensive exercise could trigger serious adverse effects such as severe arrhythmias, sudden death or an acute coronary syndrome. It is, therefore, essential before "prescribing" exercise to perform a preliminary evaluation to stratify the patient's risk and in order to recommend appropriate and well adapted exercise programs.

Cardiovascular Diseases↗

Impact of physical training and detraining on endothelium-dependent vasodilation in patients with recent acute myocardial infarction.

BACKGROUND: There is evidence that aerobic exercise improves endothelial function in healthy subjects as well as in patients with chronic heart failure. However, it is unknown whether this effect occurs in patients with recent myocardial infarction (AMI). METHODS: Fifty-two patients with a recent first uncomplicated AMI underwent endothelial function evaluation before and after 3 months of moderate aerobic exercise training. We measured brachial artery vasomotor reactivity using flow-mediated dilation (FMD), a cold pressor (CP) test, and sublingual nitroglycerin. Patients were randomized into 2 groups: 28 patients (G1) underwent training, while 24 patients (G2) served as controls. Brachial artery vasomotor reactivity was reassessed after 1 month of detraining (DT). RESULTS: At baseline the FMD was 1.66% +/- 4.11% in G1 and 2.04% +/- 3.4% in G2 (P = NS) and vasoconstriction was evident after a CP test. The diameter reduction was -4.1% +/- 3.89% in G1 and -4.39% +/- 5.67% in G2 (P = NS). At follow-up the FMD had increased to 9.39% +/- 4.87% in G1 (P <.01) and to 4.4% +/- 3.9% in G2 (P <.01 vs G1). Vasoconstriction during a CP test was observed only in G2. Endothelium-independent vasodilation was unchanged in both groups. Effort tolerance increased by 32% in G1 patients (P <.01 versus G2) and was correlated with FMD change (R = 0.51, P <.01). After detraining the FMD was significantly reduced in G1 (P <.01) and a further vasoconstriction was evident after CP testing. CONCLUSIONS: Exercise training improves endothelium-dependent vasodilation in post-AMI patients. This improvement is associated with a significant increase in exercise tolerance. These benefits disappeared after detraining.

Adult↗

[Bi-ventricular synchronous pacing and heart failure].

After initial trials of conventional DDD pacing in dilated cardiomyopathies, the concept of multisite stimulation was introduced in 1994. This new indication of heart failure treatment is based on the correction of myocardial contraction and relaxation asynchronies. European pilot studies including few patients were followed by two multicenters randomized trials (MUSTIC and MIRACLE) that confirmed a significant improvement of functional capacity, quality of life and hemodynamic status. Intraventricular delay and QRS duration shortening seems to be the best predictor of clinical success. Patients with more depressed functional and hemodynamic status seems to benefit most from this therapeutic approach. Two studies (CARE HF and COMPANION) are still conducted which will provide further insight into the effectiveness in terms of prognosis of cardiac resynchronisation therapy in this patient population.

Heart Failure↗

The role of work simulation tests in a comprehensive cardiac rehabilitation program.

BACKGROUND: One of the goals of a comprehensive cardiac rehabilitation (CR) program is the patient's return to his or her usual activities. The aims of this paper were to implement an occupational evaluation protocol in a CR and to assess patients' hemodynamic responses and ventricular arrhythmias during work simulation tests. METHODS: After an 8-week outpatient CR, 132 patients performed work simulation, lifting (MH-L) and carrying (MH-C) tests. ECG, heart rate and blood pressure were constantly monitored. RESULTS: The comparison of physiological responses during work simulation and a standard exercise testing provided the following results: 1) maximal heart rate, blood pressure and double product values during WS and MH tests were significantly lower (p < 0.001) than those measured during exercise testing; 2) higher (p < 0.001) double product values were achieved during MH-C as compared to MH-L and work simulation; 3) arrhythmias were more frequent during MH-L as compared to exercise test (p < 0.001). The increment of double product was reached much faster during work simulation and MH tests as compared to exercise testing: according to the multivariate analysis this was a predictor of a greater incidence of arrhythmias. The incidence of arrhythmias during work simulation tests and MH was significantly higher in patients with reduced tolerance to effort, valvular replacement, arrhythmias during holter monitoring, low ejection fraction and effort silent ischaemia. CONCLUSIONS: Work simulation test provide a more personal functional assessment, complementary to the exercise testing. It appears particularly useful in patients with higher functional impairment who are at a higher risk of arrhythmias.

Arrhythmias, Cardiac↗

Chronic infusion of dobutamine and nitroprusside in patients with end-stage heart failure awaiting heart transplantation: safety and clinical outcome.

BACKGROUND: in patients with severe heart failure additional therapeutic support with intravenous inotropic or vasodilator drugs is frequently employed in an attempt to obtain hemodynamic and clinical control. No data comparing the use and efficacy of chronic intravenous inotropic and vasodilator therapy in patients with advanced heart failure are available. AIMS: we evaluated, in a group of patients with advanced heart failure undergoing chronic infusion with dobutamine or nitroprusside, in addition to optimized oral therapy, (1) the safety of chronic infusion, (2) the efficacy of both drugs in managing unloading therapy and (3) clinical outcome of the two therapeutic strategies. METHODS: one hundred and thirteen patients receiving optimized oral therapy, in functional class III/IV with symptoms and signs of refractory heart failure and requiring additional pharmacological support with either intravenous dobutamine or nitroprusside were evaluated. Clinical and therapeutic management and clinical outcome of the two groups were considered. RESULTS: dobutamine was administered for 12 h/day for 20+/-23 days at a dosage of 7+/-3 microg/kg/min to 43 patients. The mean dose of nitroprusside was 0.76+/-0.99 microg/kg/min. The mean duration of use of this drug, administered as a 12-h/day infusion was 22+/-38 days. Nitroprusside infusion allowed greater doses of short-term ACE-inhibitors to be used compared to pre-infusion (ACE-inhibitor dose: 55+/-30 mg/day vs. 127+/-30 mg/day P<0.0001) and during dobutamine infusion (ACE-inhibitor dose: 85+/-47 mg/day vs. 127+/-30 mg/day P<0.002). Nitroprusside unlike dobutamine significantly improved the NYHA functional class. Of the 113 patients, 109 (97%) had a cardiac event during a mean follow-up of 337+/-264 days. Forty-four patients required hospitalization for worsening congestive heart failure, 45/113 (39%) patients died during the follow-up and 27/113 (24%) patients had a heart transplant in status one. Hospitalization, because of worsening heart failure was less frequent in the nitroprusside than in the dobutamine subgroup [29/51 (57%) vs. 19/22 (86%) P<0.02]. The overall mortality was 28% (20/70) in the nitroprusside group and 58% (25/43) in the dobutamine group (odds ratio 0.33 CI 0.16 to 0.73 P<0.006). In the group treated with nitroprusside, heart transplantation in status one was performed in 16/33 patients (48%), while in the dobutamine group this was done in 11/14 patients (78%) (odds ratio 0.25 CI 0.06-1.02 P<0.06). There was a significant reduction in the combined end-point of mortality/heart transplantation in status one in patients treated with nitroprusside compared to those treated with dobutamine (36/70 (51%) vs. 36/43 (84%) - (odds ratio 0.34 CI 0.14-0.80 P<0.01). The incidence of adverse events in the patients treated with nitroprusside was similar to that in those treated with dobutamine (20% vs. 17% P=ns). CONCLUSIONS: for patients awaiting heart transplantation chronic intermittent nitroprusside infusions are more effective and safer than dobutamine in relieving symptoms, facilitating unloading therapy management and improving survival. Whether chronic intermittent infusion of nitroprusside could represent a feasible medical strategy in out-patients with severe heart failure remains to be investigated.

Cardiac Output, Low↗

[Prognostic evaluation of silent ischemia during exercise in patient with recent infarction. Italian multicenter study. SMISS Group].

AIM: The aim of the Multicenter Silent Ischemia Study (SMISS), co-ordinated by the Italian Working Group on Cardiac Rehabilitation, was to evaluate prospectively, the prognostic significance of silent myocardial ischemia during exercise testing in patients with proven ischemic cardiac disease. METHODS: Over a period of six months 4389 consecutive patients performing a maximal symptom-limited exercise testing, after drug withdrawal, were enrolled in the 73 ergometric laboratories. All patients were followed up after 12 months, at which time electrocardiogram, examination and clinical history were reassessed. Here we report the results of 1111 patients group with the recent myocardial infarction (inferior 3 months). The follow-up was completed in 1031 (93%) patients. RESULTS: The results of exercise testing were normal in 666 (64.6%) patients; angina alone in 33 (3.2%) patients; silent ischemia in 234 (22.7%) patients; symptomatic ischemia in 98 (9.5%) patients. In 270 patients (26.1%) new events occurred: angina (19.7%); myocardial infarction (3.1%; PTCA (4%); CABG (6%); cardiac death (1.4%). The total events were more common in the patients with exercise induced angina (48.5%) and in those who had exercise induced-symptomatic ischemia (48%), in respect of patients with silent ischemia (29.5%) and of those who had normal testing (20.7%) (p = 0.0001). Myocardial infarction rate was higher in patients with symptomatic ischemia (7.1%) that for those of all other groups (silent ischemia: 1.3%, angina: 3%, normal 3.2%) (p = 0.05). Moreover, the patients with symptomatic ischemia had higher incidence of CABG (p = 0.0001). The mortality rate was low among all patients and did not show differences among the groups. Only among the 31 patients (3%) with blood pressure fall was mortality higher that in patients with a normal blood pressure increase. By multivariate logistic analysis the angina induced by exercise maintained its prognostic significance for all the events, but also other variables were significant: poor exercise tolerance and, between clinical variables angina before myocardial infarction. CONCLUSION: The results showed, in patients who underwent to exercise testing after drug withdrawal, a low incidence of cardiac death and of myocardial infarction on 12 month follow-up; the patients with induced-exercise symptomatic schema had a greater risk for all cardiac events, except for death.

Aged↗

[Multicenter study on exercise-induced silent myocardial ischemia: clinical, anamnestic and ergometric parameters in 4389 patients with proven ischemic cardiopathy].

AIM OF THE STUDY: In order to evaluate the incidence and clinical significance of myocardial ischemia during exercise testing (ExT) in patients (pts) with proven ischemic heart disease (Stable Effort Angina = SEA, Myocardial Infarction = MI, PTCA or CABG) 73 ergometric laboratories participated in a multicenter prospective study (SMISS) coordinated by the Italian Working Group on Cardiac Rehabilitation. Here we report the clinical and ergometric parameters. METHODS: Over a period of six months 4,389 consecutive pts were enrolled in the study after performing a maximal limited ExT (25 watts x 3') after drug withdrawal. All pts are followed at 6 and 12 months, at which time electrocardiogram, physical examination and clinical history were reassessed. A preliminary quality control of ECGraphic signal of ischemia was performed. Between the core center and the ergometric laboratories there was an 88% agreement (positive/negative ECG). 617 (14%) pts with angina (Group A), 2621 (59.7%) MI pts (Group B), 313 (7.2%) PTCA pts (Group C1), 838 (19.1%) patients with previous coronary bypass (Group C2) were studied. RESULTS: Interruption criteria were: maximal heart rate (11.7%), fatigue (66.6%), angina (10.9%), dispnea (2.3%), ST depression (13.9%), complex VPBs (2.2%), abnormal blood pressure (3.3%). In all pts the maximal work load was 100.3 +/- 31 W (lower in SEA pts). HR was 141 +/- 20/min at maximal work load (lower in SEA pts). The incidence of complex VPBs was 7.9% (higher in Mi and CABG pts). The results of ExT were: normal in 62% of all pts (21% in SEA pts), angina alone in 3.3% (7.6% in SEA pts and 1.8% in MI pts), symptomatic ischemia in 12.7% (40% in SEA pts, 9.3% in MI pts and 5.7% in CABG pts), silent ischemia in 22% (31.8% in SEA pts, 21.6 in MI pts and 16.6% in CABG pts). All differences were significant (p < 0.01). CONCLUSIONS: In a low risk group of coronary patients the incidence of myocardial ischemia during ExT was 38%. Ischemia was silent in 58% of the patients.

Aged↗

Echocardiographic evidence of increased mitral-aortic separation in discrete subaortic stenosis.

The present study reports the two-dimensional echocardiographic pattern of 6 patients affected by discrete subaortic stenosis. The diagnosis was proven at cardiac catheterization. The echocardiographic picture was characterized by a deformity of the left ventricular outflow tract due to an inward-protruding upper septum and to an elongated and domed mitral-aortic separation. The latter finding has been described in anatomic studies but has never been reported with wide-angle echocardiography.

Adolescent↗