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Biomedical subjects

M Vowels

Publications and source records attributed to M Vowels.

27 records · Page 2Linked to original sources
PubMed1989

Antiemetic therapy for chemotherapy-induced vomiting: metoclopramide, benztropine, dexamethasone, and lorazepam regimen compared with chlorpromazine alone.

Twenty-six children aged 4 to 15 years who were to receive cancer chemotherapy were enrolled in a double-blind, randomized, crossover trial that compared the antiemetic efficacy of a four-drug regimen (the MBDL regimen: metoclopramide, 8 mg/kg; benztropine, 0.04 mg/kg; dexamethasone, 0.7 mg/kg; lorazepam, 0.1 mg/kg), given over 24 hours, with the efficacy of chlorpromazine, 3.3 mg/kg, given in four doses over 24 hours. The MBDL regimen was more effective than chlorpromazine in both objective and subjective measures of antiemetic control. Of 26 children, 23 (89%) had less vomiting on the MBDL regimen, and 20 (77%) of 26 patients or parents preferred this regimen (p less than 0.01). The MBDL regimen reduced the number of vomiting episodes by a mean of 4.0 (p less than 0.01) and reduced the duration of vomiting by a mean of 3.7 hours (p less than 0.01). A moderate level of sedation was documented at some stage in the 24-hour period of observation in 27% on the MBDL regimen and in 35% receiving chlorpromazine. Dystonia was seen in 1 (4%) of 26 children. We conclude that the MBDL regimen is safe in children and more effective than chlorpromazine.

Adolescent↗
PubMed1980

Ingestion of hashish oil-filled condoms.

Three cases of ingestion of condoms containing hashish oil are reviewed, these being the first reported in the Australian literature. Conservation management resulted in the uneventful passage per rectum of a total of 66 intact, drug-filled packages. There was no evidence of rupture of the condoms and ensuing intoxication, or of intestinal obstruction. Clear radiological evidence of a hashish oil-filled condom was present in only one of the three cases on admission to hospital. There are no recorded human fatalities from toxicity after cannabis ingestion, and drug-filled condoms will usually traverse the normal gastrointestinal tract spontaneously. A policy of non-intervention is advised only when the drug is known to be cannabis. Operative treatment is necessary in the presence of more potent substances such as cocaine, and also to relieve intestinal obstruction.

Adult↗