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M Vukić

Publications and source records attributed to M Vukić.

5 recordsLinked to original sources
PubMed2005

Spinal contribution to CSF pressure lowering effect of mannitol in cats.

OBJECTIVES: After application of hyperosmolar mannitol the cerebrospinal (CSF) pressure is usually lowered within 30 min but this effect cannot be explained either by changes in intracranial blood volume and flow or by changes in brain volume. We assume that this effect of mannitol my be consequence of CSF volume decrease primarily in the spinal CSF due to high compliance of the spinal dura. METHODS: To explore such a possibility we planned to separate spinal and cerebral CSF. In chloralose anaesthetized cats dorsal laminectomy of C2 vertebrae was performed and a plastic semi ring was positioned extradurally separating cranial and spinal CSF. CSF pressures were recorded via cannulas positioned in lateral ventricle and lumbar subarachnoid space at L3 vertebrae, respectively. RESULTS: After intravenous bolus of 20% mannitol (0.5 or 1.0 g/kg/ 3 min) in control animals without cervical stenosis, the fall of both ventricular and lumbar CSF pressures was equal over time. At 15 min after mannitol application in cats with cervical stenosis an slight increase of ventricular and a fall of lumbar CSF pressures were observed, while at 30 min a gradient of these pressures of 5.5 and 7 cm H2O at lower and higher dose of mannitol, respectively, were registered. However, after removal of cervical stenosis these gradients disappeared. CONCLUSION: The observed changes of CSF pressures in spinal and intracranial space indicate that spinal subarachnoid space contributes a great deal to overall fall of CSF pressure and volume in the early period after mannitol application probably due to high compliance of the spinal dura.

Animals↗
PubMed2005

The investigation of cerebrospinal fluid formation by ventriculo-aqueductal perfusion method in cats.

OBJECTIVES: The perfusion of cerebrospinal fluid (CSF) spaces by artificial CSF (aCSF) containing an indicator, is an indirect method used to calculate CSF formation. To evaluate this method, we have developed a ventriculo-aqueductal perfusion method, which enables a direct measurement of CSF formation in the ventricles. METHODS: In chloralose anaesthetized cats, the aqueduct of Sylvius was cannulated so that the outflow end of the plastic cannula was positioned extracranially. Both lateral ventricles were also cannulated, with one cannula for infusion of aCSF containing blue dextrane and the other for measurement of CSF pressure. RESULTS: During ventriculo-aqueductal perfusion (direct method) under physiological CSF pressure, the outflow rate from aqueductal cannula did not differ significantly from the inflow rate, i.e. no CSF formation was observed. When the indirect method based on dilution of blue dextran in the outflowing perfusate was used, the formation of approximately 5 microl/min of CSF was obtained. CONCLUSION: Results of the direct method indicate that net CSF formation inside brain ventricles does not exist. The opposite results obtained by the indirect method questions this method as a reliable study of CSF formation.

Animals↗
PubMed1998

[Surgical treatment of lumbar disc hernias in athletes].

In a 7-year period (1988-1995) a series of 55 patients was surgically treated at our Department for lumbar disk herniation following a certain sports activity, i.e. sports injury. The above number accounts for 2% of the total number of lumbar disk patients operated upon at our Department. The majority of patients in our series were amateur athletes, whereas a few of them were active or professional athletes. The most common cause of disk herniation among our patients was playing soccer (13 cases), which is followed by basketball (8), field athletics (7), tennis (6) and handball (4). In most cases our surgical method of choice was flavectomy (interlaminectomy). Most commonly seen intraoperative finding was intervertebral disk extrusion. In some athletes the onset of symptoms was due to a change of their usual sports activity, for example a tennis player who was injured in skiing. We believe that the onset of disk herniation in athletes is a consequence of numerous micro traumas of the intervertebral disk which are further compounded by the syndrome of overstraining. In the case of a positive indication, surgical treatment leads to a faster recovery in professional athletes.

Adolescent↗
PubMed1977

[Leiomyosarcoma uteri].

The authors present a 55-year-old patient with leiomyosarcoma uteri who died six months after surgical and subsequent radiation therapy. They point out difficulties in diagnosing the disease owing to a very scarce symptomatology. The fast growth of the myoma is considered very symptomatic of a malign alteration. In the patient presented, in only eight months, a slightly myomatously increased uterus gew to the size of two male fists.

Female↗