Biomedical subjects
M W Cobb
Publications and source records attributed to M W Cobb.
A papule on the forehead. Palisaded encapsulated neuroma (PEN).
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Knuckle pads.
Knuckle pads are well circumscribed thickenings of the skin over the metacarpophalangeal and, more commonly, the proximal interphalangeal joints. Although the association with several other clinical syndromes including Dupuytren's disease is well documented, most cases are idiopathic. We present a case of knuckle pads and briefly review the history and course of this disease.
Localized, perifollicular cold urticaria.
Cold urticaria is a condition with many clinical variants. We present the case of a young woman with a localized, perifollicular form that we believe represents a new and distinct clinical subtype of cold urticaria. We review other established clinical subtypes of cold urticaria.
Xanthomatized atypical T cells in a patient with mycosis fungoides and hyperlipidemia.
BACKGROUND: Lipoprotein-T-cell interactions are being reported with increasing frequency, and there is evidence that lipoproteins play a role in immunoregulation. We describe a patient with mycosis fungoides and hyperlipidemia who developed xanthomatization in one preexisting plaque. The case is unique in that some of the lipidized cells were atypical T cells. In previously reported cases of mycosis fungoides with dystrophic xanthomatosis, the lipid-containing cells have been identified only as histiocytes. OBSERVATIONS: Immunopathologic features, electron microscopy, and lipid stains of the xanthomatized plaque demonstrated that some of the lipid-laden cells were atypical T cells. CONCLUSIONS: In mycosis fungoides, malignant T cells may be intimately involved in processing of tissue lipids. We suggest that low-density lipoprotein receptors on activated T cells facilitated the cytoplasmic lipidization in this case.
Waldenström macroglobulinemia with an IgM-kappa antiepidermal basement membrane zone antibody.
BACKGROUND: Waldenström macroglobulinemia, a lymphoplasmacytoid cell malignant neoplasm associated with a monoclonal IgM paraprotein, has been associated with a number of cutaneous manifestations. On rare occasions, IgM deposits have been demonstrated in the epidermal basement zone of patients with WM. OBSERVATIONS: We report the case of a patient with Waldenström macroglobulinemia and IgM-kappa paraprotein who had development of an eruption of pruritic papules and demonstrated the following unusual immunopathologic findings: (1) deposits of IgM-kappa in the epidermal basement membrane zone of lesional and nonlesional skin; (2) a circulating IgM-kappa antiepidermal basement membrane zone antibody; and (3) binding of this circulating IgM-kappa antiepidermal basement membrane zone antibody to both sides of 1 mol/L sodium chloride split skin. The cutaneous eruption cleared completely with oral psoralen with long-wave UV radiation in the A range (PUVA) therapy. CONCLUSIONS: We present a patient with Waldenström macroglobulinemia who had a distinctive papular eruption and immunopathologic findings suggesting that his paraprotein has specificity for the epidermal basement membrane zone.
Digitate dermatosis.
Two cases of digitate dermatosis are presented. The clinical and histopathologic features of this unique entity are reviewed. We suspect that digitate dermatosis may be more prevalent than reported.
Solitary papule on the forearm. Solitary reticulohistiocytoma.
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Human papillomavirus infection.
The human papillomavirus, well known as the etiologic agent of warts, has recently received much attention in the medical literature for its association with various cancers. This article discusses the virology, epidemiology, pathogenesis, immunology, clinical manifestations, and therapy for human papillomavirus infection. Some newer techniques for identifying human papillomavirus in tissue, based on recent advances in molecular biology, are also covered. Two final topics addressed are human papillomavirus infection in the immunocompromised host, including patients with acquired immunodeficiency syndrome, and the possible role of human papillomavirus in several different carcinomas.
Porokeratotic eccrine ostial and dermal duct nevus: a case of systematized involvement.
We describe a case of porokeratotic eccrine ostial and dermal duct nevus presenting as widespread, symmetrical lesions. To our knowledge, this represents the most extensive case of this entity reported to date. Both the localized and systematized variants of this nevoid condition are discussed.
Furosemide-induced eruption simulating Sweet's syndrome.
This case report describes an 88-year-old man who developed an eruption that clinically and histologically simulated Sweet's syndrome 6 weeks after furosemide therapy was started. The rapid resolution of lesions on discontinuation of the medication, as well as several features atypical for Sweet's syndrome in this case, favored the diagnosis of drug eruption. A review of adverse cutaneous reactions induced by furosemide is also presented.
Squamous cell carcinoma following fluorouracil-responsive 'keratoacanthoma'.
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