Biomedical subjects
Publications and source records attributed to M W Elliott.
Karyotypic study of a population sample of twenty-one owl monkeys, Aotus, originating from Bolivia, revealed two sex-specific somatic diploid chromosome numbers: 49 for males and 50 for females. The presence of a trivalent in male meiotic figures and the identification of chromosomes by band pattern analysis confirmed the interpretation of a Y-autosome translocation in the males.
Attempts to establish successful breeding colonies of Aotus trivirgatus at this and other laboratories have largely been unsuccessful, resulting in only occasional pregnancies and a rare live birth. After the recognition of seven different karyotypes of owl monkeys, animals were paired on this basis and resulted in a marked increase in conceptions. From 1971 to 1975 only 10 pregnancies occurred but during 1975, there were 19 pregnancies. In addition to proper karyotyping, a period of acclimation and conditioning was required. Mean body measurements and weights of infants were established.
Explore the source record for details and available documents.
Explore the source record for details and available documents.
Geriatric day care is currently receiving considerable attention as an alternative to institutionalization for a certain segment of our nation's chronically ill and impaired elderly. There are, however, few clear descriptions of day care and even fewer programmatic guidelines. In an effort to clear up some of the issues, this paper (a) defines geriatric day care and describes various types of geriatric day care centers, (b) discusses the place of day care in the long-term care continuum, and (c) describes the Levindale Adult Day Treatment Center as one model of geriatric day care.
In recent years there has been increasing interest in the relationship between obstructive sleep apnoea and stroke. It is clear that many patients who have had a stroke have marked obstructive sleep apnoea. This is seen during recovery but also during the acute phase when transient hypoxaemia and the blood pressure swings associated with upper airway obstruction, may worsen the ischaemic penumbra of the area of the brain which is compromised, leading to a worse outcome. There is some evidence to support this hypothesis. This article explores these issues.
NPPV is a major advance in respiratory and critical care medicine. In the acute setting, it has a clear role in the management of patients with COPD who are acidotic, and in weaning from IMV. NPPV in hypoxic RF shows promise for selected patients, but further studies are required. For domiciliary use, NPPV is effective in both the short and long term for the management of extrapulmonary restrictive disease, but further research is required for COPD.
Explore the source record for details and available documents.
BACKGROUND: Infiltration with local anaesthetic (LA) is recommended before arterial puncture (AP) for blood gas analysis. A telephone survey of 100 junior hospital doctors established that 84% never used LA; the reason for this cited by 47% of doctors was that they considered the injection to be as painful as AP itself. We therefore undertook a randomised double blind placebo controlled trial to establish whether the recommendation for LA is justified. METHODS: Patients undergoing AP were randomly allocated to one of three groups before arterial stab: A--Infiltration with 2% lignocaine; B--Infiltration with normal saline; C--No infiltration. Patient and doctor then rated the discomfort of the procedure. RESULTS: Both patients and doctors rated the pain of AP less when LA was used. Infiltration with LA was no more painful than with placebo. AP was no more difficult following LA as assessed by passes made, times skin broken and the doctor's rating of the procedure. CONCLUSION: This study supports the recommendation that LA should be infiltrated before radial artery puncture is performed. The belief that the use of LA makes the procedure more difficult and is as painful as arterial puncture should be dispelled.