Biomedical subjects

M W Ingeman-Nielsen

Publications and source records attributed to M W Ingeman-Nielsen.

5 recordsLinked to original sources

PubMed1996

[Risk factors for depression after apoplexy].

An unselected cohort of 285 stroke patients, median age 69 years, was studied for correlation between potential risk factors and the one-year incidence of post-stroke depression (PSD). The following factors correlated significantly to PSD a history of previous stroke, a history of previous depression, female gender, living alone and social distress pre-stroke. Further, social inactivity, decrease in social activity, pathological crying and intellectual impairment at one month but not functional outcome correlated to PSD. A multivariate regression analysis showed that intellectual impairment explained 42% of the variance of the mood score. Major depression was unrelated to lesion location. We conclude the etiology of PSD is a complex mixture of pre-stroke personal and social factors and stroke-induced social, emotional and intellectual handicap.

Adult↗

PubMed1990

[Arteriosclerosis in Greenlanders].

X-ray examination of the lumbar spine of 268 Greenlanders and a corresponding number of Danes were reviewed in order to diagnose arteriosclerotic lesions of the abdominal aorta. In 10.4% of the Greenlanders and 11.6% of the Danes major calcifications were found. The two groups did not differ in distribution of age and sex of patients with arteriosclerotic lesions. It is known that arteriosclerotic complications occur less frequently in Greenlanders than in Danes. The study seems to indicate that this cannot be explained by a rarer occurrence of generalized arteriosclerosis.

Adult↗

PubMed1990

[Radiographic examination of the lumbar spine in Greenlanders].

X-ray examinations of the lumbar spine from a two-year period in 268 Greenlanders and an equivalent number of danes were reviewed in order to diagnose all radiological lesions. Twenty-five percent of the X-ray examinations of the Greenlanders and 28% of the Danes showed normal conditions. Eighteen percent of the Greenlanders and 3% of the Danes had evident sacroliitis. Four Greenlanders and one Dane had radiological ankylosing spondylitis. The high frequency of sacroiliitis can probably be explained by the genetic structure of the population and the pattern of infections. Spondylolisthesis was found in 24% of the Greenlanders, confirming previous findings. Degenerative lesions, fractures, developmental anomalies and Scheuermann's disease were equally frequent in the two populations, while scolioses were less frequent among the Greenlanders than among the Danes.

Adolescent↗

PubMed1990

[Radiographic examination of the stomach in Greenlanders].

X-ray examinations of the stomach and duodenum from a two year period of 135 Greenlanders and an equivalent number of Danes were reviewed in order to diagnose all radiological lesions. The results are presented. In 37% of the Greenlanders and 51% of the Danes, x-rays showed normal findings. Peptic ulcerations were diagnosed for the first time in 2.4% of Greenlanders over the age of 15 years. The incidence of gastric ulcer was 1.5% and of duodenal ulcer 0.9%. The male/female ratio was 1.3 in Greenlanders. The esofagus and cardia region of the Greenlanders revealed many serious lesions, emphasizing the importance of further investigations in this area. The incidence of peptic ulcer disease and gastric ulcer is higher than the incidence in Denmark but approximately the same as in the Faroe Islands. The incidence of duodenal ulcer is found to be lower among Greenlanders than in the other two populations.

Adult↗

PubMed1990

Double blind placebo controlled trial of pulse treatment with methylprednisolone combined with disease modifying drugs in rheumatoid arthritis.

OBJECTIVE: To assess whether monthly treatment with intravenous methylprednisolone enhances or accelerates the effect of disease modifying drugs in patients with rheumatoid arthritis. DESIGN: A 12 month double blind, placebo controlled, multicentre trial in which patients with active rheumatoid arthritis were randomly allocated to receive pulses of either methylprednisolone or saline every four weeks for six months. At the start of the pulse treatment all patients were started on penicillamine or azathioprine. SETTING: Four rheumatology departments in Denmark. PATIENTS: 97 Patients (71 women, 26 men) aged 23-84 (mean 60) who had active rheumatoid arthritis of at least four weeks' duration despite treatment with non-steroidal anti-inflammatory drugs. MAIN OUTCOME MEASURES: Monthly clinical recording of morning stiffness, number of tender and swollen joints, blinded observers' evaluation of therapeutic effect, and patients' self assessed condition. Concomitant laboratory measurements of erythrocyte sedimentation rate and concentrations of C reactive protein and haemoglobin. Radiography to determine the number of erosions at the start of treatment and after 12 months. RESULTS: 57 Patients completed the trial, taking the same disease modifying drug throughout. Evaluation four weeks after each pulse treatment and at 12 month follow up showed no significant differences between the methylprednisolone and placebo groups in any of the clinical or laboratory variables. Radiography showed the same degree of progression of erosions in both groups. Evaluation of the total data on 97 patients and on the 57 who completed the trial showed the same lack of significance between the treatment groups. CONCLUSIONS: Intravenous pulse treatment with steroids can be recommended only for rapid temporary relief of flares of disease in patients with rheumatoid arthritis. The response is short lived. Repeated pulses of methylprednisolone at four week intervals do not improve the results of treatment with drugs that induce remission such as penicillamine and azathioprine.

Adult↗