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Biomedical subjects

M W Korn

Publications and source records attributed to M W Korn.

12 recordsLinked to original sources
PubMed2002

Evaluation of long-term toxicity in patients after cisplatin-based chemotherapy for non-seminomatous testicular cancer.

BACKGROUND: Because of the increasing number of long-term survivors of metastatic testicular germ-cell cancer, a general concern has been secondary morbidities, especially cardiovascular risk factors. PATIENTS AND METHODS: Thirty-two patients treated with cisplatin- and doxorubicin-containing chemotherapy > or = 13 years before the time of analyses were evaluated for neuro-, oto-, pulmonary-, vascular- and gonadal toxicity including evaluation of myocardial damage and cardiovascular risk factors and analysis of microcirculation. RESULTS: Thirty percent of the patients showed abnormal left ventricle function. Elevated follicle stimulating hormone (FSH) and luteinising hormone (LH) levels in 75% of patients were often associated with low testosterone levels. Elevated total cholesterol levels were found in 82% and higher triglyceride levels in 44% of patients, most of them were overweight. About 25% of the patients developed diastolic arterial hypertension after chemotherapy. Reduced hearing was confirmed in 23% of patients, especially at frequencies higher than 3000 Hz. Moreover, 53% of patients presented transient evoked otoacoustic emissions. In 38% of patients non-symptomatic neuropathy was detected, in 28% symptomatic neuropathy, and in 6% disabling polyneuropathy. In 80% of patients with neuropathic symptoms additional morphological and functional abnormalities were found by nailfold capillary videomicroscopy, compared to only 57% of the patients without neuropathic symptoms. CONCLUSIONS: Patients cured by cisplatin-based chemotherapy for metastatic testicular cancer have to be cognizant of their unfavorable cardiovascular risk profile, that might be a greater risk than developing a relapse or second malignancy.

Adolescent↗
PubMed1997

Phase II trial of continuous oral trofosfamide in patients with advanced colorectal cancer refractory to 5-fluorouracil.

Fourteen patients with 5-fluorouracil (5-FU) refractory, progressive colorectal cancer metastatic to liver and/or lung were treated with continuous oral trofosfamide, an alkylating agent structurally related to cyclophosphamide and ifosfamide. Trofosfamide was given daily at 200 mg/day. No objective partial or complete responses were seen in 14 evaluable patients. There were four patients with stable disease or minor responses; the median duration of stable disease during trofosfamide treatment was 14 weeks, with of range of 12-36 weeks. Mild to moderate side effects were reported in seven patients including grade 1-2 nausea in four patients, grade 1 leukopenia in two patients and grade 1 anemia in one patient. Trofosfamide in this dose and schedule shows minor activity in 5-FU refractory colorectal cancer. Because of very little side effects, dose escalations appear to be possible.

Adult↗
PubMed1996

A new approach to dome high tibial osteotomy.

This article describes a study that evaluates a combined arthroscopy and high tibial osteotomy treatment protocol incorporating: a new curved and double-bladed barrel vault (dome) osteotomy guide; measurement of the mechanical axis of the limb during surgery as well as measurement of the femorotibial angle and mechanical axis before and after surgery; and prior arthroscopic evaluation and debridement. Forty-five high tibial osteotomies were performed in 42 patients. All 45 knees had varus angular deformity. Arthroscopy confirmed osteoarthritis in all 45 knees and grade 4 medial compartment chondromalacia in 44 of 45 knees. Patients were evaluated preoperatively and postoperatively using a grading scale modified from that of the Hospital for Special Surgery. Follow-up of patients ranged from 1 to 6 years (mean: 3.1 years). The average clinical score was 57.4 preoperatively and 89.8 postoperatively, an improvement of 56.4%. All patients achieved and maintained pain relief compared with their preoperative status. No patient needed total knee replacement. These results indicate that in patients with unicompartmental osteoarthritis with angular deformity, high tibial barrel vault (dome) osteotomy can improve the quality of life while preserving the knee joint. There was no relationship between clinical score and either patient age or severity of lateral compartment chondromalacia. Therefore, osteotomy may be appropriate for a larger population than generally thought.

Adult↗
PubMed1985

Is there still a role for knee arthrography?

To assess the continued value of arthrograms in the wake of arthroscopic diagnosis, an analysis of arthrographic data on 240 knees was carried out. The accuracy, sensitivity, and specificity of the arthograms were compared with the arthroscopic findings for each knee. For meniscal lesions, the arthrogram is reasonably accurate. An algorithm is presented that defines the relative roles of arthrography and arthroscopy.

Arthrography↗
PubMed1979

Correlations of arthrography with arthroscopy.

Arthrography and arthroscopy were compared on a prospective basis in 100 consecutive and unselected knees, all in patients who underwent arthrography, arthroscopy, and surgery. Arthroscopy was found to be more accurate than arthrography in the diagnosis of medial and lateral meniscus and anterior cruciate ligament lesions. Because of its easy availability and relatively low cost, arthrography continues to be a useful extension of the physical examination of the knee, serving as a further diagnostic screening technique. However, arthroscopy is recommended in all patients prior to surgery because it provides more complete and more accurate delineation of intra-articular lesions.

Cartilage, Articular↗
PubMed1976

Ossicle of the meniscus.

Two patients with an ossicle of the meniscus are described. Radiologic differentiation from osteochondral loose body or chondrocalcinosis can be made by its ossified appearance and its location within the meniscus. Correct diagnosis is important so that unnecessary surgery is avoided and a protracted search for a free fragment is not carried out.

Adult↗