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Biomedical subjects

M W Moncrieff

Publications and source records attributed to M W Moncrieff.

At least 19 recordsLinked to original sources
PubMed1985

Clinical presentation, growth, and pubertal development in Addison's disease.

The clinical course of eight boys and six girls with Addison's disease has been reviewed. Adrenal antibodies were found in five boys and five girls, and four children showed clinical evidence of other autoimmune disease (hypoparathyroidism (three); diabetes (one)). The presentation was insidious in 12 children but acute in two. On treatment, linear growth was normal and, with the exception of one girl with theca cell antibodies, pubertal development proceeded normally in the older patients.

Addison Disease↗
PubMed1982

Early biochemical findings in familial hypophosphataemic, hyperphosphaturic rickets and response to treatment.

Regular biochemical measurements were made in 4 babies, each of whom had one parent with familial hypophosphataemic, hyperphosphaturic rickets. Hypophosphataemia developed by 2 months and levels of alkaline phosphatase had increased by 3 months in all four. Decreased tubular reabsorption of phosphate and x-ray changes of rickets did not develop until 6 months in 3 of the babies. In the fourth these abnormalities developed at 9 days and 3 months. The babies were treated with oral phosphate and small doses of 1-alpha-hydroxy-cholecalciferol. The rickets healed readily in 3 babies and their linear growth kis within the normal range. Healing took much longer in the remaining child and his linear growth is below the 3rd centile. Hypercalcaemia has not been a problem of treatment.

Alkaline Phosphatase↗
PubMed1980

Familial hyperparathyroidism.

A mother and her 12-year-old son both had a parathyroid adenoma. They represent a further example of dominant inheritance of isolated hyperparathyroidism.

Adenoma↗
PubMed1978

Isolated ACTH deficiency. Metabolic and endocrine studies in a 7-year-old boy.

Metabolic and endocrine studies on a 7-year-old boy who presented with hypoglycaemic convulsions are reported in detail, proving the diagnosis of isolated ACTH deficiency--a rare cause of hypoglycaemia in childhood. Adrenaline secretion during insulin-induced hypoglycaemia was reduced. Low blood alanine levels occurred during starvation-induced hypoglycaemia, together with raised total blood ketone bodies; blood glucose did not increase adequately after oral alanine at this time. Hypoglycaemia in isolated ACTH deficiency appears to be due to a combination of impaired alanine mobilisation and a decreased rate of gluconeogenesis.

Adrenocorticotropic Hormone↗
PubMed1978

Case of tumour rickets.

A 10-year-old boy, with widespread soft tissue tumours of bone, developed hypophosphataemic rickets due to impaired renal tubular reabsorption of phosphate. Biopsy of the largest tumour showed a nonosteogenic fibroma. We believe this boy is another example of 'tumour rickets', as other causes of rickets were excluded clinically and biochemically. Cases of rickets or osteomalacia associated with a tumour, have generally been reported to be cured by surgical removal of the tumour, implicating it as the cause of rickets or osteomalacia. Owing to the large number of tumours in this boy, surgical removal was not possible, and he required large doses of vitamin D, together with oral phosphate, before his rickets healed. It is suggested that the tumour produces a phosphaturic hormone.

Bone Neoplasms↗
PubMed1977

Management of prolonged hypoglycaemia in Beckwith's syndrome.

A new-born baby with Beckwith's syndrome had severe hypoglycaemia, and was treated with glucagon and prednisone. Treatment was stopped at 1 month of age and his blood glucose levels were satisfactory for the ensuing 6 weeks. However, at 10 weeks of age, he had a hypoglycaemic convulsion and required large doses of diazoxide and prednisone for the next 2 months to maintain the blood glucose above 40 mg/100 ml. Insulin excretion was raised until he was 4 months old. Cases of Beckwith's syndrome which develop hypoglycaemia, should be treated with diazoxide and corticosteroids until insulin excretion is normal.

Abnormalities, Multiple↗
PubMed1976

Value of cystography in urinary tract infections.

Fifty-one children with a bacteriologically proven urinary tract infection had both an intravenous urogram (IVU) and a micturating cystogram. The IVU was normal in 35. Only 6 of these children showed reflux in the cystogram, affecting 7 of the 70 ureters at risk. Since reflux on its own does not cause renal damage, which occurs only with super-added infection, detection of reflux is not important providing the urine is kept sterile. We suggest that cystography be deferred providing the IVU is normal until recurrent infections occur while under hospital care, and, with this policy this unpleasant and sometimes hazardous investigation could be avoided in many children with a single urinary tract infection.

Child↗
PubMed1976

Phototherapy for hyperbilirubinaemia in very low birthweight infants.

Phototherapy was used to treat 20 newborn babies whose birthweight was below 1500 g and whose plasma bilirubin exceeded 8 mg/100 ml. The plasma bilirubin level was maintained below 13 mg/100 ml except in 4 babies whose level exceeded 13 mg/100 ml before treatment was started. In 60% of an untreated group of larger babies previously reported the plasma bilirubin level exceeded this figure. Phototherapy seems to control the plasma bilirubin level satisfactorily in very low birthweight infants, but frequent measurements on the second and third days of life are advised in order that treatment may be started promptly when it exceeds 8 mg/100 ml.

Bilirubin↗
PubMed1975

What is rickets?

Explore the source record for details and available documents.

Adolescent↗