Fluoxetine abuse.
OBJECTIVE: In this report, we describe the abuse of fluoxetine (an antidepressant) in two patients who had histories of substance abuse. MATERIAL AND METHODS: Specific details of the stimulant effects of fluoxetine, used in excessive dosages and in conjunction with other drugs, are discussed. RESULTS: After hospitalization, our two patients were able to discontinue use of fluoxetine and had improved mentation. CONCLUSION: Although the mechanism for this phenomenon is unknown, we postulate that drug craving and behavioral factors are involved.