Biomedical subjects

M W Pettet

Publications and source records attributed to M W Pettet.

9 recordsLinked to original sources

PubMed2001

Colinear facilitation promotes reliability of single-cell responses in cat striate cortex.

Behavior is controlled by neural activity in the brain. The final outcome of this neural control may critically depend on the firing reliability of individual neurons. A nearly constant, proportional relationship is usually found between the response mean and response variance. Here we asked whether lateral interactions within striate cortex that modulate response magnitude also proportionately modify the response variance of cortical neurons. In many cases, response variability depended on stimulus organization: discrete flankers colinearly placed well outside the neuron's receptive field increased response magnitude without a proportional increase in variance, thus improving the neuron's response reliability. Since colinear flanker facilitation is often seen near the neuron's firing threshold, increased response reliability for weak stimuli may contribute to enhancing perceptual saliency.

Animals↗

PubMed1999

Shape and contour detection.

Detectability of contours may be affected by long-range interactions between neurons in early stages of visual cortex. Specifically, neurons with receptive fields arrayed along the length of a contour may facilitate each other in a position- and orientation-dependent manner. Accordingly, the overall geometry of a contour should significantly influence both the strength of these long-range interactions and the contour's detectability. Psychophysical experiments measuring the detectability of sampled, curvilinear contours hidden by randomly-oriented and -positioned noise elements revealed two main findings. First, changes in direction of curvature degraded contour detectability. Second, the effect of changes in magnitude of curvature were predicted by the average of local curvature along the length of the contour. While the first result emphasizes the importance of uniform direction of curvature, the second result rules out penalties for deviation from circularity.

Female↗

PubMed1998

Collinear stimuli regulate visual responses depending on cell's contrast threshold.

Neurons in the primary visual cortex are selective for the size, orientation and direction of motion of patterns falling within a restricted region of visual space known as the receptive field. The response to stimuli presented within the receptive field can be facilitated or suppressed by other stimuli falling outside the receptive field which, when presented in isolation, fail to activate the cell. Whether this interaction is facilitative or suppressive depends on the relative orientation of pattern elements inside and outside the receptive field. Here we show that neuronal facilitation preferentially occurs when a near-threshold stimulus inside the receptive field is flanked by higher-contrast, collinear elements located in surrounding regions of visual space. Collinear flanks and orthogonally oriented flanks, however, both act to reduce the response to high-contrast stimuli presented within the receptive field. The observed pattern of facilitation and suppression may be the cellular basis for the observation in humans that the detectability of an oriented pattern is enhanced by collinear flanking elements. Modulation of neuronal responses by stimuli falling outside their receptive fields may thus represent an early neural mechanism for encoding objects and enhancing their perceptual saliency.

Animals↗

PubMed1998

Constraints on long range interactions mediating contour detection.

Contour detection may be mediated by lateral interactions between neighboring cortical neurons whose receptive fields have collinear axes of preferred orientation. This hypothesis was tested in psychophysical experiments and computer simulations using a contour detection task in which observers searched for groups of Gabor patches that followed spatially extended contour paths embedded in noise consisting of several hundred Gabor patches with random positions and orientations. The orientation-selective units in the simulated neural network were linked by facilitatory interconnections whose strength depended on the geometry (distance, curvature, change in curvature) of smooth curves connecting the orientation axes of units in a pairwise fashion. Psychophysical detection performance was much higher for contour signal groups that followed closed rather than open-ended paths. However, just two sudden changes in orientation of neighboring Gabor patch elements in closed-path contours reduced detection performance to the same levels obtained with open-ended contours. These psychophysical data agreed with the results of the neural network simulations. Furthermore, the simulations also accounted for previous findings that removal of a single Gabor patch element from a closed-path contour group significantly degraded detection performance. We conclude that closure alone is not sufficient to enhance the visibility of a contour. However, if a closed contour meets certain geometric constraints, then lateral interactions based on these constraints can generate facilitation that reverberates around the closed path, thereby enhancing the contour's visibility.

Form Perception↗

PubMed1997

Spatial interactions modulate stereoscopic processing of horizontal and vertical disparities.

Stereoscopic processing of horizontal and vertical disparities was assessed by measuring how the stereoscopic appearance of test dots near the fixation point was influenced by inducing stimuli in the near periphery. The inducing stimuli were differentially magnified in the two eyes and varied in horizontal eccentricity. As expected, when the inducers were horizontally magnified, the test dots exhibited depth contrast, slanting in depth in a direction opposite the slant of the inducing dots. When the inducers were vertically magnified, the test dots slanted in depth around a vertical axis toward the eye with the larger vertical image (the induced-size effect). However, two lines of evidence suggested that an eccentricity-dependent weighted average of horizontal and vertical components of inducer-dot magnification determined the slant of the test dots. First, as the horizontal eccentricity of the inducing dots was varied, the trend of test-dot slants measured with vertical inducer magnifications was predicted by the trend of test-dot slants measured with horizontal inducer magnifications. Second, test-dot slants measured with a combination of both horizontal and vertical inducer magnification could be predicted by simply adding test-dot slants measured with either horizontal or vertical inducer magnification alone.

Computer Graphics↗

PubMed1992

Detection and processing of vertical disparity by the human observer.

Based on the distinction between uniocular vertical magnification and vertical disparity, the induced size effect experiments were reinterpreted and new experiments done to show that vertical disparity signals can produce other stereoptic depth effects. The direction and efficiency of utilization of vertical disparity signals depend on the quadrant of the visual field and the stimulus position within it.

Humans↗

PubMed1992

Dynamic changes in receptive-field size in cat primary visual cortex.

Immediately after focal retinal lesions, receptive fields (RFs) in primary visual cortex expand considerably, even when the retinal damage is limited to the photoreceptor layer. The time course of these changes suggests that mere lack of stimulation in the vicinity of the RF accompanied by stimulation in the surrounding region causes the RF expansion. While recording from single cells in cat area 17, we simulated this pattern of stimulation with a pattern of moving lines in the visual field, masking out an area covering the RF of the recorded cell, thereby producing an "artificial scotoma." Over approximately 10 min this masking resulted in a 5-fold average expansion in RF area. Stimulating the RF center caused the field to collapse in size, returning to near its original extent; reconditioning with the masked stimulus led to RF reexpansion. Stimulation in the surrounding region was required for the RF expansion to occur--little expansion was seen during exposure to a blank screen. We propose that the expansion may account for visual illusions, such as perceptual fill-in of stabilized images and illusory contours and may constitute the prodrome of altered cortical topography after retinal lesions. These findings support the idea that even in adult animals RFs are dynamic, capable of being altered by the sensory context.

Animals↗

PubMed1990

Contrast and duration of exposure differentially affect vernier and stereoscopic acuity.

Although stereoacuity and vernier acuity both yield comparable thresholds well below the eye's resolution limit, the neural circuits for these two classes of visual responses do not process the signals in an identical manner. It had previously been demonstrated that hyperacuity is more resistant to image blur than stereoacuity and that the zones within which two targets must be placed to achieve the lowest thresholds differ quite radically. Two further differences are reported here: reduced contrast affects stereoacuity more severely than hyperacuity, as also does shortening of exposure into a range of tens of milliseconds, even when the Bunsen-Roscoe-Bloch law has been factored out.

Aged↗

PubMedDate not supplied

Facilitation and suppression of single striate-cell activity by spatially discrete pattern stimuli presented beyond the receptive field.

Visual stimulation of a region outside the receptive field of single cells in visual cortex often results in the modulation of their responses. The modulatory effects are thought to be mediated through lateral connections within visual cortex. Research on lateral interactions commonly shows suppression. There has been no systematic study of the optimal conditions for facilitation. Here we have studied the nature of the modulation using a new type of compound stimulus: contrast reversal of pattern stimuli made of three discrete grating patches. The middle patch, optimally fitted to the receptive field in orientation, size, and spatial as well as temporal frequencies, was flanked by two similar patches presented well outside the receptive field. We found that (1) both facilitation and suppression occurred often in the same cells, when orientations of the target and flankers matched the receptive-field's optimal orientation; (2) facilitation with collinear flankers occurred most frequently at target contrasts just above the cell's firing threshold and suppression prevailed at high contrasts; (3) facilitative or suppressive modulation was obtained with target-flankers separation of up to 12 deg or more; (4) collinear facilitation was lost when flankers' orientation was rotated by 90 deg, while keeping all other parameters the same; and (5) neither the modulation mode nor the proportion of modulated cells was related to the cell types (simple vs. complex cells) and cells' laminar locations. Here we have provided physiological evidence for contrast-dependent, collinear facilitation probably underlying perceptual grouping in humans.

Animals↗