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Biomedical subjects

M W Rohovsky

Publications and source records attributed to M W Rohovsky.

16 recordsLinked to original sources
PubMed1983

The activity of closantel as an equine antiparasitic agent.

Eighteen pony foals were experimentally infected with 500 third stage larvae of Strongylus vulgaris at 2 weeks, and at 2, 4, 6 and 8 months after birth. For the duration of the study, all foals were kept in the same pasture with their mothers to allow natural infection with other parasites by exposure to a contaminated environment. Twelve of the foals were utilized in groups of 3 and treated orally five times at two month intervals starting at one month of age with closantel at doses of 5, 10, 20 or 40 mg kg-1. Ten months after birth the foals were necropsied to determine the parasitic burdens in the gastrointestinal tracts and the cranial mesenteric arteries. The results indicate a high antiparasitic activity of closantel against larval stages of Gasterophilus intestinalis and S. vulgaris, as well as against adult S. vulgaris, S. edentatus, Anoplocephala perfoliata and Triodontophorus spp., when used at doses of 20 or 40 mg kg-1.

Animals↗
PubMed1979

The effect of coffee consumption on plasma lipids, lipoproteins, and the development of aortic atherosclerosis in rhesus monkeys fed an atherogenic diet.

Rhesus monkeys (seven females and six males) were fed ad libitum a diet comparable to that consumed by humans, containing 25% by weight fat (40% of calories) and 0.15% cholesterol (0.3 mg/kcal) for 12 months (phase 1). From the 13th month all monkeys were continued on the diet while four females and three males were given 50% coffee as their fluid intake and the remainder were water controls (phase 2). Major changes in total plasma lipids and lipoprotein profiles occurred within 3 months and generally plateaued thereafter. Total plasma protein remained constant while total plasma cholesterol, phospholipids, triglycerides, and free fatty acid levels increased. After the initiation of coffee, there was no difference between the diet-water group and the diet-coffee group with respect to total protein and lipids in plasma. Total concentrations of plasma lipoproteins varied throughout the study. The pre-beta (very low density lipoproteins) fraction remained constant while the beta (low density lipoprotein) and alpha (high density lipoprotein) fractions, along with their major components, increased within 3 to 6 months, then fluctuated in absolute weight thereafter. The introduction of 50% coffee was without effect on the dynamic changes in these fractions as fluctuations were found in both groups and to the same magnitude. This leads the authors to suspect that such variations are "normal" or are in response to the diet per se. The atherogenic diet induced fatty streaks in the aortas of all monkeys to a greater extent in males than females. However, there were no gross differences in the quantity or distribution of the streaks between control and coffee-drinking monkeys.

Alanine Transaminase↗
PubMed1975

Meningitis caused by Klebsiella spp in two rhesus monkeys.

Two adult, female rhesus monkeys (Macaca mulatta) became depressed, weak, anorectic, and adipsic. Auscultation of the thorax of 1 monkey revealed bilateral harsh rales. Neither monkey responded to therapeutic doses of antibiotics, and both died soon after treatment was started. Meningitis was demonstrated histologically and pure cultures of multiply antibiotic-resistant Klebsiella were isolated from the brains of both monkeys. Of 13 clinically normal rhesus monkeys in the same facility, 5 had multiply antibiotic-resistant Klebsiella spp in their pharynges.

Animals↗
PubMed1966

The germfree cat.

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Alopecia↗