Genetically directed representational difference analysis-based positional cloning and snorthern analysis of candidate genes.
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Biomedical subjects
M W Sornson
Publications and source records attributed to M W Sornson.
Pituitary lineage determination by the Prophet of Pit-1 homeodomain factor defective in Ames dwarfism.
The gene apparently responsible for a heritable form of murine pituitary-dependent dwarfism (Ames dwarf, df) has been positionally cloned, identifying a novel, tissue-specific, paired-like homeodomain transcription factor, termed Prophet of Pit-1 (Prop-1). The df phenotype results from an apparent failure of initial determination of the Pit-1 lineage required for production of growth hormone, prolactin or thyroid-stimulating hormone, resulting in dysmorphogenesis and failure to activate Pit-1 gene expression. These results imply that a cascade of tissue-specific regulators is responsible for the determination and differentiation of specific cell lineages in pituitary organogenesis.
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