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Biomedical subjects

M W Strötges

Publications and source records attributed to M W Strötges.

At least 19 recordsLinked to original sources
PubMed1985

[Function tests of the lower small intestine with 75selenium-labeled homotaurocholic acid in Crohn disease and resections of the small intestine].

UNLABELLED: Faecal excretion of bile acids was investigated using 75Se-homotaurocholic acid (75SeHCAT) in a total of 75 patients: 9 with irritable colon, 58 with Crohn's disease and 8 with small-bowel resection due to various indications but without Crohn's disease. Bile acid malabsorption, taken as a pathological bile acid retention of less than 19%, was found present in 43 patients with diseased terminal ileum or with more than 20 cm resection of this organ, except in one case (12 cm). On the other hand a normal bile acid retention (21 to 27%) was found in 29 of 72 patients (including 9 patients with irritable colon) who showed either no radiologically detectable lesion of the ileum (n = 21) or changes involving an extension of up to 30 cm (inflammation or resection) in the terminal ileum (n = 8), with the exception of one case (50 cm). Three patients had a raised bile acid excretion contrary to clinical expectation: they had colitis Crohn without radiologically detectable involvement of the small intestine. Thus using the 75SeHCAT-retention test it seems possible to recognize functional disorders in diseased segments of the bowel before the appearance of radiologically detectable changes. CONCLUSION: 75SeHCAT is a suitable substance for investigations on the function of the lower small intestine.

Adolescent↗
PubMed1983

[Comparative studies of various methods of measuring bile acid secretion using 75Se-labelled homotaurocholic acid (75Se-HCAT)].

The simple determination of whole-body retention of the bile acid analogue 75Se-HCAT provides results which are in agreement with those of the established but more difficult measurement of 24-14C-TCA excretion in the feces. Determining whole-body retention of 75Se-HCAT is not only practicable with a whole-body counter but also, with precision, with the more widely used gamma camera. Therefore, the bile acid retention test may be employed wherever there is a gamma camera available.

Bile Acids and Salts↗
PubMed1981

Scintiphotographic studies for long-term results in carotid cavernous sinus fistulae.

Scintiphotographic studies as a method for analyzing the brain perfusion in carotid cavernous sinus fistulae before and after surgical treatment with different techniques are presented. Twelve patients have been reexamined long after their operation to prove the sufficient crossover circulation through the circle of Willis while the homolateral carotid artery is impatent. Sufficient perfusion of both hemispheres could be well-documented by this radionuclide method. No neurological deficit was found in clinical examination either.

Arteriovenous Fistula↗
PubMed1981

[Analysis of vesico ureteral reflux by functional scintigraphy (author's transl)].

With a large view scintillation camera and gamma 11/34 DEC-System it is possible to detect a reflux out of the bladder, if the volume is 0.2 ml or larger. Description of the function of upper urinary tract is given. Time of reflux beginning a bladder volume combined with measurement of intravesical and intraabdominal pressure and more details of the reflux dynamic are demonstrated. Background activity and absorption of body soft tissue should be corrected by phantom measurement. The results of investigations of 26 patients are shown in tables and by examples of morphologic and functional analyses.

Adolescent↗
PubMed1980

[Intraoperative localization measurement following preoperative radioiodine marking to facilitate the treatment of differentiated thyroid carcinoma].

Patients with differentiated carcinomas of the thyroid gland (n = 25) and patients with receptive lymph node metastases (n = 10) who had all undergone total thyroidectomy were marked with 131iodine 48 h before undergoing lymphonodectomy. The thoroughness of the resection was checked by the intraoperative use of a detector. There was a significant decrease in the postoperative areas visible on the scintigrams of a group of patients who had been operated upon without the intraoperative use of a detector. There were also fewer complications in this control group owing to a more subtle operative procedure.

Adenocarcinoma↗
PubMed1979

[Diagnosis of tumors of the parotid gland by sialography and saialoscintigraphy. A comparative study on 49 patients (author's transl)].

169 patients with different diseases of the salivary glands were examined by means of sialography and sialoscintigraphy. The results of these examinations were analysed by a blindfold test. The sialographic diagnosis was correct for 47 of 49 tumors checked by histologic examinations. There is no specific criterium for the scintigraphic determiation of a tumor; there are concentrations as well as filling defects and retentions. The correct side, however, was found by scintigraphy in 46 cases. Only if a Warthin's tumor is suspected, the diagnosis can be confirmed by scintigraphy if a concentration is found. Generally, sialoscintigraphy should only be executed if sialography has technically failed. A distinction by means of sialography of benign and malignant tumors is not possible.

Adolescent↗
PubMed1978

[Diverse findings in cranial CT and scintigraphy in space occupying lesions (author's transl)].

Incongruent statements in CT and scintigraphy may disturb therapy planning. Many years of scintigraphy have presented here an established method. Cranial CT was performed here with 2000 persons in one year. Parallel CT and scintigraphy was performed in about 350 cases. There were some cases with positive findings in CT and negative in scintigraphy and vice versa. These cases will be compared with the definite diagnosis, we will discuss the different findings and the relevance of both methods as a diagnostic aid for the neurosurgeon and therapeutic radiologist.

Brain Neoplasms↗
PubMed1978

[Nuclear medicine diagnosis of pulmonary embolism (author's transl)].

Pulmonary embolism is an emergency situation. The earlier therapy begins, the more effective it will be. This, however, asks for immediate diagnosis. At present the most effective method of diagnosing and localizing pulmonary embolism is perfusion scintiscan of the lung. It should be completed by chest radiography to exclude peripheral infiltration and/or central lung cancer. Generally, these two procedures ensure optimal diagnosis. In case of additional disease of the pleura, mediastinum and lung parenchyma, further measures may be necessary: especially in chronic obstructive lung disease ventilation perfusion ratio and outwash of xenon might be helpful. Scintiscan of the lung is suited for early diagnosis as well as for follow-up examinations. Only if thrombectomy is planned, pulmonary angiography should be preferred. Scintiscan of the lung with marked particle suspensions ensures a minimum of complications. There is only one incident in 10,000 examinations. According to Quinn (1964) and Felix (1971) pulmonary scintiscan might be harmful in patients with right heart failure. We made no such observation in 4000 cases.

Albumins↗
PubMed1976

The diagnostic value of sialography and scintigraphy in salivary gland diseases.

The diagnostic value of sialographic and scintigraphic investigations was compared in 169 patients. In this group were 75 inflammatory diseases and 49 benign and malignant tumours. Sialograms and scintigrams were examined by different physicians who had no knowledge of the clinical data of the patients. The scintigraphic diagnosis was considered correct if any abnormal finding was noted. The sialographic diagnosis was considered correct if the actual disease was diagnosed. In spite of the less stringent requirements for a correct scintigraphic diagnosis the sialographic technique was found to be superior. Radioactivity uptake curves over the salivary glands did not improve the scintigraphic diagnostic accuracy.

Humans↗
PubMed1976

[Behavior of the TSH level in thyroidectomized patients after thyrotropin releasing hormone (TRH)].

Following operation or/and radioiodine therapy in 69 patients with malignant tumors of the thyroid gland the plasma level of TSH was increased independently of the level of thyroid hormone and of a clinical finding of hypothyroidism. In all cases it was possible to stimulate the secretion of TSH with TRH (p less than 0,0005). Therefore, application of TRH may be helpful to increase the uptake of iodine by metastases. On the other hand substitution of thyroid hormones--thyroxine or triiodothyronine or both combined--resulted in normal levels of TSH and normal response to TRH.

Humans↗
PubMed1976

[Aims and limits of nuclear medicine methods in investigation of malignant and benign bone lesions (author's transl)].

In primary bone tumors the possibilities of bone scans are discussed. Exact differentiation between malignant and benign disease by this method is impossible. However, scanning provides important information about extent of the disease, metastases, multiplicity of benign lesions and influence of adjoining diseases to the bone. A special indication exists in cases of cerebral meningiomas and an absolute indication for searching osteoplastic metastases, e.g. in carcinomas of the breast and the prostate gland.

Bone Diseases↗
PubMed1976

In vitro determination of unbound and total iron-binding capacity in serum by radioiron using a new ion exchange strip.

A simplified method for the in vitro determination of TIBC and UIBC in serum using 59Fe was subjected to quality control in the laboratory and clinically studied in duplicate determinations of 185 sera of an unselected patient population. The data obtained were investigated by statistical means (regression, correlation, variance analysis). The precision of the method was evaluated step by step. The results indicate that the radiochemical determination of TIBC values is equivalent to the "indirect" one (UIBC + SI) as far as accuracy is concerned. Advantages of the radiochemical method are discussed.

Humans↗
PubMed1975

[Dose-time effects of competitive displacement of radiopertechnetate by sodium perchlorate following oral and intravenous administration].

The effect of various doses of sodium perchlorate in several dose fractions on the extent and the time scale of displacement of radiopertechnetate, in dependence on application mode, was studied. An intravenous dose of 50 mg perchlorate was in respect of competitive suppression of organs actively concentrating pertechnetate as effective as intravenous 1000 mg ClO-4- simultaneously or 1000 mg orally 30 min before the injection of radiopertechnetate. An intravenous injection of perchlorate given later also produces a complete and immediately beginning depletion of pertechnetate already accumulated in the thyroid, within a period of 195 min after 99m-TcO-4-injection with a corresponding increase in blood levels. 20 mg result in incomplete depletion which becomes complete after a second additional dose. The intravenous application of perchlorate offers advantages in clinical use.

Administration, Oral↗