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Biomedical subjects

M Wahba

Publications and source records attributed to M Wahba.

9 recordsLinked to original sources
PubMed1988

Development of Leishmania major in the phlebotomine sandflies, Phlebotomus papatasi (Scopoli) and Phlebotomus langeroni (Nitzulescu).

Laboratory bred Phlebolomus papatasi and P. langeroni were examined for their susceptibility to develop Leishmania major promastigotes under laboratory conditions. Promastigotes were demonstrated in the gut of both species when they were given sugar 24 hr before or after an infective blood meal and in flies offered only an infective blood. The overall infection rate was slightly higher in P. langeroni than P. papatasi. Head promastigotes were detected in P. papatasi provided with sugar 24 hr before or after an infective blood meal. No head promastigotes were seen in flies offered only infective blood. In P. langeroni, head promastigotes were only seen in flies fed on sugar before or after an infective blood and maintained at 18 degrees C. Results indicate that sugar plays a major role in the migration of parasites from the gut to the head. Temperature may have a marginal effect on the migration process. Attempts to transmit L. major to hamster by the bite of infected P. papatasi were not successful.

Animals↗
PubMed1981

Cognitive changes in acute schizophrenia with brief neuroleptic treatment.

The authors studied 44 acutely decompensated, hospitalized schizophrenic patients who were placed on a double-blind basis for 10 days in three treatment groups: patients given high, moderate, and standard doses of haloperidol. To assess changes in the patients' concentration, abstract thinking, and ability to respond appropriately they administered two clinical rating scales and three psychological tests. Patients in all three treatment groups showed similar and significant improvements according to both clinical and psychological ratings after haloperidol administration. Normal control subjects showed no change in psychological test scores over time. The authors conclude that brief treatment with neuroleptics produces measurable improvement in schizophrenic thinking.

Adolescent↗
PubMed1980

Haloperidol for acute schizophrenic patients. An evaluation of three oral regimens.

The relative efficacy of three oral regimens of haloperidol was compared in a ten-day, double-blind study of 63 acutely ill schizophrenic patients newly admitted to the hospital. One group of patients received 20 mg of haloperidol on day 1, then increasing increments of 20 mg a day, reaching a maximum dosage of 100 mg daily on day 5. Another group received 10 mg of haloperidol on day 1, then increasing increments of 10 mg daily, reaching 100 mg daily on day 10. A third group of patients received a fixed dosage of 10 mg daily for ten days. Haloperidol was well tolerated by the patients; there were no serious adverse reactions. The data indicated that the regimens had similar therapeutic efficacy, suggesting that acutely ill schizophrenic patients respond to a wide range of doses of haloperidol but that onset of response and efficacy are not increased in most patients by providing a high initial loading dosage. Adequate, safe dosage must be determined in each case.

Acute Disease↗
PubMed1978

High vs standard dosage fluphenazine HCL in acute schizophrenia.

This rater blind project compared the efficacy and safety of using an oral rapid or neuroleptization method (maximum 80 mg./day) versus fixed standard dosage (20 mg./day) fluphenazine, a commonly used neuroleptic. There were 32 hospitalized, acutely decompensated schizophrenic patients in the experiment; the study period for each patient was a maximum of 7 days. The data were collected using the Benjamin Proverb Test and rating scales for psychopathology and adverse effects. Data analysis by means of the analysis of covariance demonstrated few significant differences between the 2 treatment methods: both methods produced a similar reduction in psychopathological symptoms and incidence of adverse effects. The authors conclude that the rapid neuroleptization method is not superior to the fixed standard dosage method in treating acute schizophrenia.

Acute Disease↗