Biomedical subjects
Publications and source records attributed to M Walkowiak.
A case of 54-year-old man with a rare degenerative condition of the iris stroma is presented. Described iridoschisis has developed in superior part of iris. Open-angle glaucoma and degeneration of vitreous was associated.
PURPOSE: The present study was designed to evaluate a possible participation of serotonin in the development of retinopathy in diabetes mellitus. MATERIAL AND METHODS: Serotonin of whole blood and platelets was studied in 12 patients with Type I and II diabetes using high pressure liquid chromatography method. RESULTS: The concentration of serotonin in the blood was markedly increased (210 +/- 50 ng/ml in diabetes and 150 +/- 35 ng/ml in control, p < 0.01) and not changed in platelets in diabetes. There was a relation between blood serotonin level and the presence of retinopathy. CONCLUSION: These results suggest that serotonin may be involved in the pathogenesis of diabetic microangiopathy.
BACKGROUND: In the anterior segment of the eye, fibrin clots must be rapidly resorbed to prevent fibrosis. Tissue-type plasminogen activator (t-PA), a serine protease that catalyzes the conversion from plasminogen to plasmin, plays an important role in the fibrinolytic system and has therefore in recent years attracted attention in the field of ophthalmology. MATERIAL AND METHODS: The aqueous humor of patients undergoing cataract surgery was analyzed for the presence of components of the fibrinolytic cascade. The quantities of t-PA and plasminogen-activator inhibitor (PAI) were determined using enzyme-linked immunosorbent assays. We determined t-PA and PAI in the aqueous humor of 64 patients between 59 and 82 years of age. RESULTS: The t-PA levels ranged from 0.65 to 1.75 ng/ml and PAI activity from 3.24 to 5.1 AU/ml. Association between t-PA levels and PAI activity and accompanying diseases or metabolic disorders was noted. The highest concentration of t-PA and the lowest activity of PAI has been observed in aqueous humor of patients with senile cataract. The knowledge about the presence of t-PA in aqueous humor is significant for the recognition of pathological events following intraocular fibrin formation and may be an important basis for therapeutic use of t-PA.
Seven children with an atypical parasitic uveitis were treated in the Department of Ophthalmology in Bialystok in the period 1985-1989. Parasitic background had been discovered in all the children: toxocara in 3, lambliasis in 2 and nematodiasis also in 2. Specific treatment achieved an improvement of the visual acuity and the inflammatory process abated.
The objective of this study was to determine by shear bond strength testing the efficacy of Gluma batches produced between 1985 and 1990 and stored at either 23 degrees C or varying temperatures between 19 degrees and 32 degrees C. The average bond strength figures for the thirty variable conditions tested were not significantly different from each other on the 0.05 significance level. Chemical analysis of the individual Gluma Primer batches investigated proved that the concentration of the main active ingredients of the mixture, glutaraldehyde and HEMA, were not or only moderately reduced when compared with the composition determined on the dates of manufacture. It was concluded that this bonding system is stable over a period of 6 years when possible extremes in storage temperature are avoided.
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Clinical course of the case of a now 20 patient, with glioma of the optic nerve, removed 12 years ago, is presented. The tumour was removed with a intraorbital part of the optic nerve, but the eyeball was saved, what enabled the normal, symmetrical development of the child's face. Painful atrophy of the eyeball occurred 10 years after surgery and it seems that there will be a necessity to remove the eye.
The methods and results of histopathological and immunohistochemical investigation of an optic nerve tumour removed in a 6-year girl are presented. The difficulties were connected with a proper differential diagnosis between schwannoma and astrocytoma.