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Biomedical subjects

M Wallack

Publications and source records attributed to M Wallack.

10 recordsLinked to original sources
PubMed2000

Pedunculated malignant melanoma.

BACKGROUND: The pedunculated melanoma is an unusual variant of nodular melanoma that presents a challenge in staging and management. OBJECTIVE: We discuss the clinical and histopathologic characteristics of a case of pedunculated melanoma and present a brief review of the literature. METHODS: Routine stain with hematoxylin and eosin was performed on tissue specimens. RESULTS: The pedunculated melanoma was excised. Sentinel lymph node dissection was performed and was negative for the presence of melanoma. CONCLUSIONS: Pedunculated melanoma is a rare type of melanoma. Conventional staging methods for melanoma may not be reliable in this type of tumor. Complete workup, possibly including sentinel lymph node dissection, should be performed in all patients with pedunculated melanomas.

Adult↗
PubMed1999

A Brunner's gland adenoma as a cause of anemia.

Benign tumors of the small bowel are rare. They present with many different manifestations depending on the size and location, and also cause a variety of symptoms that are often nonspecific. These include abdominal pain, dyspepsia, nausea, vomiting, and gastrointestinal bleeding that may be melena or hematemesis. Most of the time patients are asymptomatic and the lesions are discovered as an incidental finding. When bleeding occurs, and it may be severe in certain situations, the patient may develop signs of anemia, such as dyspnea, fatigue, and even high-output cardiac failure. The authors present a patient who was evaluated for melena and who was found to have a duodenal polyp that proved to be a Brunner's gland adenoma on pathology.

Adenoma↗
PubMed1997

Combinatorial antibodies against human malignant melanoma.

The general responsiveness of human melanoma to immunotherapy has been well established, but active immunotherapy of melanoma has been hampered by insufficient information on the immunogenicity of melanoma antigens in patients. We have attempted to identify melanoma-associated antigens recognized by patients' B cells using an antibody phage display approach. Antibody display on filamentous phages allows direct screening of cDNA libraries for expression of cell-surface-reactive antibodies, without the need for antibody production and purification using bacteria or eukaryotic cell systems. This approach was used to identify melanoma-associated cell-surface antigens recognized by patients' B cells. Antibodies produced by the B cells of a melanoma patient (in remission for > 7 years following periodic vaccination with allogeneic melanoma cell vaccine) were displayed as Fabs on the surfaces of filamentous phages. A library of 10(8) phages was absorbed to normal melanocytes, followed by phage binding to and elution from melanoma cells (human lymphocyte antigen nonmatched and vaccine melanoma cells). Phages were further selected for reactivities with tunicamycin-treated melanoma cells. These procedures resulted in a > 10(6)-fold enrichment of tumor-specific phages from the original phage library. One phage-Fab bound to melanoma cells, other tumor cells, and a few normal cells in cultured cell lines and in tissue sections.

Antibodies, Neoplasm↗
PubMed1989

Enteritis cystica profunda in a patient with Crohn's disease.

Colitis cystica profunda is an uncommon but well-recognized condition affecting the colon. Involvement of the small bowel, enteritis cystica profunda, is extremely rare, and is characterized by mucus-filled cystic spaces frequently lined by demonstrable epithelium. The cystic spaces are located within the submucosa and muscularis propria. Isolated cases have been described in association with Peutz-Jeghers syndrome and Crohn's disease. We report a case of enteritis cystica profunda in a 31-year-old man with Crohn's disease.

Adult↗
PubMed1986

Surgical experience of colon resection in the extreme elderly.

A retrospective review was undertaken at Mount Sinai Medical Center of Miami Beach for patients aged 70 and greater undergoing colon resection between January 1, 1983 and December 31, 1983. These resections were performed for carcinoma 67.3 per cent, diverticular disease 10.9 per cent, and other indications 21.8 per cent. The operations were performed by different surgeons with a wide spectrum of procedures and associated simultaneous procedures. The morbidity and mortality were reviewed. Complications occurred in 27.7 per cent (38 complications in 28 patients). The complication rate was highest in those with diverticular disease. The overall mortality rate was 4.95 per cent with a zero mortality in patients undergoing elective colon resections. It would appear that with careful monitoring and avoidance of emergency surgery, colon resection can be safely undertaken in this elderly portion of the population.

Age Factors↗