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Biomedical subjects

M Walther

Publications and source records attributed to M Walther.

At least 91 records · Page 5Linked to original sources
PubMed1983

[Morphometrically definable aging velocities of cells and tissues].

We determined aging changes of the nucleus-cytoplasm-relation in the epithel of the human epiglottis and intestine of rats. The results were compared with data about the proliferation of connective tissue and the decrease of muscle cells in the wall of the intestine and in the ciliary muscle. We adapted exponential functions to the measured results. For comparing the several equations and the derivable aging velocities, the nucleus-cytoplasm-relation must be transformed into nucleus volume rate of the total cell volume. Similarities in the decrease of the aging speed in the course of life and in the value of the exponent of the aging function by W. Beier (approximately 0,03) were demonstrated.

Aging↗
PubMed1983

Experimental chemotherapy of Taenia saginata cysticercosis - a field trial.

The resistance to reinfection of calves following chemotherapy of T. saginata cysticercosis with praziquantel was investigated in a field situation in East Africa. Thirty animals from the treated group were compared with thirty animals from the untreated group after 15 months following chemotherapy. Slicing revealed that 100% in the untreated group were infected, compared with 43.5% of the animals in the treated group. 52% of the untreated group had viable cysts in contrast to only one animal (4.3%) in the treated group. Serological investigations were also conducted on sera obtained before and after chemotherapy. Successful chemotherapy resulted in temporarily increased titres in the treated group as compared to the untreated group.

Animals↗
PubMed1981

[Mammary cysts and their treatment by puncture].

The authors present a study of 631 breast-cyst punctures. Apart from statistics concerning the occurrence of these cysts, a simple and economical therapy using puncture and subsequent insufflation with air is described. The cysts were diagnosed with the aid of ultrasonics, pneumocystography and cytology. In 90% of the cases complications such as haematomas and infections occurred, and recurrence of the cysts was observed in 7.1% of the patients. Puncture of cysts means that the women do not have to undergo unnecessary operations and subsequent cosmetic corrections. The treatment carries no operative or anaesthetic risks. Intra- and para-cystic carcinoma is easily recognized and patients are not burdened with radiation treatment.

Adult↗
PubMed1980

The treatment of infection and septicemia in the newborn.

The authors discuss the reasons for the frequently fatal outcome of infections in the newborn and report their own bacteriological findings in cases of perinatal infections. The predominant organisms were group D streptococci, staphylococcus aureus, E. coli, and anerobic bacteria, most of which were sensitive to clindamycin. Following introduction of clindamycin therapy, in combination with an aminoglycoside or ampicillin, the duration of hospitalization was shortened by an average of six days, and the duration of treatment by an average of three days.

Anti-Bacterial Agents↗
PubMed1978

[Selective proximal vagotomy with or without pyloroplasty. Results of a prospective randomized study].

The authors report on the one-to-five year results of a prospective randomized trial of proximal gastric vagotomy (PGV) with and without pyloroplasty in 64 men operated upon electively for chronic duodenal ulcer. The effects of the operation on gastric secretion tested at six months with pentagastrin and insulin were identical in both groups. There were fewer long-term side effects in the group without pyloroplasty. The differences between the groups do not reach statistical significance. So far no recurrent ulcers have been found in this series. It is concluded that a drainage procedure is unnecessary with PGV and that the long-term results of the operation are probably better when not combined with a pyloroplasty.

Duodenal Ulcer↗
PubMed1978

Effect of pyloroplasty on gastric emptying: long term results as obtained with a labelled test meal 14-43 months after operation.

The mean gastric transit time (t) and the half-time of gastric emptying (t/2) of a labelled test meal have been studied in 18 patients more than 1 year after gastric surgery for peptic ulcer and compared with those in 18 healthy controls. Of the patients, 6 had undergone proximal gastric vagotomy alone (PGV), L had had proximal gastric vagotomy and pyloroplasty (PGVP) and in 6 truncal vagotomy and pyloroplasty (TVP) had been performed. The t and t/2 of patients with PGV alone did not differ significantly from the values of the control group. The t and t/2 in patients after PGVP and TVP, however, were significantly lower than in both controls and patients after PGV alone. There was no statistically significant difference between the groups with PGVP and TVP. The results of this study suggest that the lasting effects of vagotomy operations on gastric emptying are due to the drainage procedure rather than the vagotomy.

Adult↗
PubMed1978

Results of a controlled randomized trial of proximal gastric vagotomy with and without pyloroplasty.

The 1--5 year results of a prospective randomized trial of proximal gastric vagotomy (PGV) with and without pyloroplasty in 64 men operated upon electively for chronic duodenal ulcer are reported. The effects of the operation on gastric secretion, as tested at 6 months with pentagastrin and isulin, were the same in both groups. There was no statistically significant difference in the clinical results between the two groups. The authors conclude that the addition of pyloroplasty makes little, if any, difference to the results of PGV. Pyloroplasty is thus better omitted as it adds nothing of value and may increase the risk of the procedure.

Adult↗