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Biomedical subjects

M Waluga

Publications and source records attributed to M Waluga.

13 recordsLinked to original sources
PubMed1991

[Endoscopic prosthesis of the biliary tract].

In the years 1987--1989 endoscopic biliary tree stenting was performed in 64 patients. The straight prostheses type Amsterdam 10 or 12 F and double pigtail prostheses were applied. In 36 cases the indication for stenting was malignant stricture of the biliary tree (group I) caused by carcinoma of the ampulla of Vater (n = 12), carcinoma of the head of the pancreas (n = 15), common bile duct and bifurcation tumor (n = 5) and gallbladder cancer (n = 4). In 28 cases the indications were common bile duct stones (group II) where stone size made endoscopic removal impossible and surgery was contraindicated. Normalisation or improvement of elevated serum bilirubin level was observed quite quickly after stenting (it decreased to about 50% of initial value after 7 days). Mean duration of prosthesis patency in group I patients who avoided surgical treatment was 144 days and mean survival time was 220 days. In group II patients mean duration of prosthesis patency was 183 days. Endoscopic biliary tree stenting is an advantageous alternative to surgical palliative++ treatment of obstructive neoplastic jaundice and constitutes an efficient method of treating common bile duct stones in poor operative risk patients.

Adult↗
PubMed1990

[Effect of physical exercise and heat on energy expenditure in obesity].

The effect of exercise and thermal stress on energy expenditure was studied in obese and lean subjects. The group of obese subjects comprised 20 women with body weight 81-159 kg, and the control group included 12 lean women weighing 51-58 kg. The energy expenditure was assessed by the method of indirect calorimetry with a Spirolyt II apparatus. The heart rate, the systolic and diastolic pressure were measured. The tested subjects were subjected to a 60 W (60 J/s) exercise on a cycle ergometer during 10 minutes, and immediately after it they were exposed to hot air in a chamber at about 60 degrees for 30 min. On the following day this sequence was reversed, with exercise following heat exposure. In the obese women the energy expenditure at rest was 93.4 +/- 17.5 W, and during exposure to heat after exercise it was 124.0 +/- 21.3 W. During exercise preceded by heat exposure it was 436.3 +/- 51.6 W. In lean subjects the corresponding values were lower: 77.5 +/- 6.5 W, 104.0 +/- 14.8 W, 376.8 +/- 36.1 W. After calculation of energy expenditure per 1 m2 of body area this expenditure was, however, lower in the group of obese subjects. The exposure to physical exercise before thermal stress increased significantly the energy expenditure in relation to that caused by each of these exposures separately. The heart rate and the systolic and diastolic blood pressures were higher in obese subjects. In both groups thermal stress increased the heart rate and systolic pressure but decreased the diastolic pressure.(ABSTRACT TRUNCATED AT 250 WORDS)

Adolescent↗
PubMedDate not supplied

The theophylline disposition after caffeine administration in liver cirrhosis: an index of liver function.

Six blood samples covering a 24 hr post caffeine dosage were drawn in 8 healthy subjects and 18 patients with liver cirrhosis. Caffeine and theophylline concentration were assayed by gas-chromatography and fluorescent polarization immunoassay, respectively. In normals the maximum theophylline levels were found between 3 and 8 hrs (62.5% at 8 hrs) and ranged 50-420 ng/ml, whereas these levels in cirrhotic patients were noted between 3 and 12 hrs (61.1% at 8 hrs) and ranged 40-670 ng/ml. The largest difference in mean theophylline concentration between normals and cirrhotics was found at 6 hrs (348 +/- 103.7 ng/ml vs 217.1 +/- 140.8 ng/ml; p less than 0.02) and 24 hrs (101.6 +/- 57.3 ng/ml vs 172.2 +/- 119.6 ng/ml; p = 0.075) after caffeine dosing. Theophylline formation rate (theo6) differentiated controls from cirrhotics in the initial stage of the disease (Child-Pugh A), however it failed to discriminate between initial and late cirrhosis. In contrast, the ability of liver to remove theophylline (theo24) differentiated effectively these groups of patients. Theo6 to theo24 ratio was a valuable index of liver function, although its capacity to detect early cirrhosis was unsatisfactory.

Adult↗