Rest pain and leg ulceration due to syphilitic osteomyelitis of the tibia.
Explore the source record for details and available documents.
Aged↗
Biomedical subjects
M Walzman
Publications and source records attributed to M Walzman.
Blood ascorbic acid and histamine levels in patients with placental bleeding.
Concentrations of histamine and total ascorbic acid (L-ascorbic acid plus dehydroascorbic acid) in the antecubital vein blood of women in abruptio placentae (normally situated placentae) and placenta praevia have been measured. The results show that blood ascorbic acid in abruptio placentae is significantly (P less than 0.05) lower than the values found in placenta praevia. This may reflect impaired absorption and/or increased breakdown of ascorbic acid in abruptio placentae. Histamine levels in the two conditions are similar to one another.
Abruptio Placentae↗
Effects of tranexamic acid on the coagulation and fibrinolytic systems in pregnancy complicated by placental bleeding.
Treatment with the fibrinolytic inhibitor tranexamic acid was investigated in 12 women with vaginal bleeding in the second half of pregnancy. The aim of the therapy was to accelerate haemostasis in the uteroplacental circulation and to prevent further bleeding at the placental site. Tranexamic acid 1 g 8-hourly was given for 7 days. Serial investigations of coagulation and fibrinolysis were carried out. Plasma fibrinolytic activity, plasminogen, antiplasmin and platelet count significantly decreased during treatment, while antithrombin III and factor VIII related antigen showed a significant increase. Plasma tranexamic acid levels ranged from 5 mg/l to 17 mg/l. Two patients on treatment at the time of delivery had plasma tranexamic acid levels of 9 mg/l and 12 mg/l detected in the umbilical cord venous blood. No adverse effects were detected in any of the mothers and all 12 were delivered of live born infants. Tranexamic acid may have a therapeutic role in accelerating haemostasis in the uteroplacental circulation and thereby reducing the adverse effects of bleeding at the placental site.
Blood Coagulation↗
Relationship of total ascorbic acid to prostaglandins F2 alpha and E2 levels in the blood of women during the 3rd trimester of normal pregnancy.
Concentrations of Prostaglandins E2 and F2 alpha in the peripheral venous blood of women during the third trimester of normal pregnancy have been estimated using radioimmunoassay techniques. These values have been related to the levels of total ascorbic acid in the blood. It appears that AA acts to control the ratio between PGE2 and PGF2 alphja in the body. This effect may in turn be mediated via its actions on histamine levels. We have already suggested that AA acts as a modulator to control the synthesis, release and/or breakdown of histamine in the body.
Ascorbic Acid↗
Levels of total ascorbic acid and histamine in the blood of women during the 3rd trimester of normal pregnancy.
Levels of total ascorbic acid and histamine in the peripheral venous blood of women during the third trimester of normal pregnancy have been estimated. The results suggest that ascorbic acid acts as a modulator to control the synthesis and/or release of histamine in the body. Low levels of ascorbic acid may be essential to stimulate the synthesis and/or release of histamine while in high concentrations it may function to inhibit the release and/or to enhance the breakdown of excessive quantities of histamine in the body. Substantial evidence is now available that histamine, perhaps its nascent variety, is essential for growth and repair processes in the body. It is possible that ascorbic acid in low concentrations acts to stimulate this variety of histamine while its high concentrations act to control the levels of histamine released from storage sites which contain preformed histamine.
Adolescent↗
The adolescent female prostitute and sexually transmitted diseases.
Prostitution may be seen as an adolescent's cry for help. A review into the background of the problem, the groups and individuals involved and the incidence of sexually transmitted diseases amongst them is presented. Psychological analysis and behavioural trends, especially in relation to attitudes towards sex, sexually transmitted diseases and intravenous drug abuse are examined.
Adolescent↗
Balanitis (balanoposthitis) in patients attending a department of genitourinary medicine.
Eighty-six patients with balanitis/balanoposthitis who presented at the department of genitourinary medicine in Coventry between October 1989 and August 1990 were investigated. While 34 (41%) cases had no specific aetiological factor Candida spp. accounted for 26 cases (30%), and group B beta haemolytic streptococci for 11 cases (13%) (one patient, a diabetic, was culture positive for both Candida spp. and group B beta haemolytic streptococci). The remaining 14 patients had other miscellaneous causes of balanitis/balanoposthitis.
Adolescent↗
Management of cervical intraepithelial neoplasia in departments of genitourinary medicine--a national survey.
A national survey of the methods used in the diagnosis and treatment of cervical intraepithelial neoplasia (CIN) in the departments of genitourinary medicine (GUM) in the United Kingdom had been conducted through a postal questionnaire. The findings indicate that at present of 157 responders to the questionnaire, 43 (27.3%) take an active part in the management of CIN. The different modes of management and follow-up are presented.
Coitus↗
Self sampling as part of screening for sexually transmitted diseases in clinic attenders. A preliminary study.
Self sampling of the secretions of the female genital tract for microbiological investigations for Neisseria gonorrhoeae, Chlamydia trachomatis and Trichomonas vaginalis was assessed in female attenders of the genitourinary medicine clinic in Coventry and Warwickshire Hospital. The purpose of the study was to evaluate the possibility of offering this method of investigation to workers in the sex industry, who are reluctant to attend GUM Clinics. This Pilot Study aimed at assessing the feasibility and acceptability of self sampling of the secretions of the lower genital tract by female patients and its reliability in the detection of sexually transmitted infections. The analysis of the data from 75 participants, indicated that 7 infections were detected on patient sampling as compared to 11 on samples taken by a physician. Self sampling may prove a valuable alternative for the sex industry workers who are reluctant to attend GUM clinics.
Adolescent↗
Treatment of external genital warts comparing cryotherapy (liquid nitrogen) and trichloroacetic acid.
BACKGROUND AND OBJECTIVES: To evaluate and compare the efficacy and adverse effects of trichloracetic acid and cryotherapy (using liquid nitrogen) in the treatment of external genital warts. STUDY DESIGN: Eighty-six patients were enrolled into a randomized clinical trial in the Genitourinary Medicine Department of the Coventry and Warwickshire Hospital (Coventry) between November 1990 and June 1991. External genital warts were treated with either trichloracetic acid or cryotherapy (using liquid nitrogen) on a once weekly basis. They received up to six treatments of either therapy. RESULTS: Complete clearance of warts in patients who received up to six treatments of cryotherapy were observed in 86% of cases and in 70% of patients who received up to six treatments of trichloracetic acid. Thirty percent of patients who were treated with trichloracetic acid developed ulcerations at the site of its application. CONCLUSION: In this study we found that cryotherapy (using liquid nitrogen) is more effective than that of trichloracetic acid for the treatment of external genital warts. It is also less likely to cause ulceration.
Condylomata Acuminata↗