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Biomedical subjects

M Wanic-Kossowska

Publications and source records attributed to M Wanic-Kossowska.

At least 19 recordsLinked to original sources
PubMed2001

Acute and chronic urinary tract infections caused by Chlamydia trachomatis.

Chlamydia trachomatis is one of the causes of acute and chronic urinary tract infections and acute or silent salpingitis. Chronic or recurrent female urinary or genital tract infections with Chlamydia trachomatis have been recognised as a significant factor in the development of acute or chronic renal interstitial inflammation or increased risk of ectopic pregnancy. In most cases Chlamydia trachomatis is sexually transmitted. Moreover, it is one of the most common sexually transmitted pathogens. The current estimate is that in the United States there occur 4.5 million new infections each year. We describe 3 cases of recurrent urinary tract infections due to Chlamydia trachomatis.

Acute Disease↗
PubMed1999

[The efficacy of the substitution of carnivit in patients with chronic failure treated with hemodialysis].

Low serum concentration of the carnitine is one of the causes of muscle weakness and cardiomyopathy in patients with chronic renal failure treated by hemodialysis. The carnitine facilitate transport of the free fatty acid into the straitened muscle cells where the product of oxidation is energy-ATP. In the present paper we presented the investigation of the influence of L-carnitine substitution on cardiac performance. The results indicate the positive influence of this treatment on metabolic and haemodynamic cardiac parameters. The subjective patients opinion of L-carnitine treatment was also positive.

Adult↗
PubMed1998

Sclerosing encapsulating peritonitis.

In this report, three cases of sclerosing encapsulating peritonitis (SEP) are described; two of them were associated with pleural and/or pericardial effusions.

Adult↗
PubMed1998

[Arterial hypertension due to perirenal hematoma after renal percutaneous biopsy].

We report three cases in which arterial hypertension occurred after percutaneous renal biopsy due to perirenal hematoma. Perirenal hematoma is common complication of renal biopsy. The mechanism of hypertension depends on renal ischemia. Compressive ischemia decrease the renal blood flow, increase mechanism RAA, the amount of urine is decreased, with low sodium concentration and finally the arterial hypertension appears.

Adult↗
PubMed1998

[Levels of L-carnitine in serum of patients with chronic renal failure treated by hemodialysis (HD)].

Low serum levels of the carnitine in chronic uremic patients treated by hemodialysis is one of the causes of muscle weakness. In 50 patients with chronic renal failure treated by HD and in 13 nondialyzed patients EMG and measurement of nerve conduction velocity were performed. In 25 of 50 patients treated with HD and in 13 non-dialyzed patients serum concentration of free and total carnitine were measured. In HD patients serum level of carnitine was significantly lower as compared to the control group of healthy subjects and to the nondialyzed patients. In all patients the EMG investigations showed the traits of the neurogenic atrophy of the muscles. The correlation between the amplitude of muscle potentials and serum levels of carnitine suggests that the depletion of carnitine may play a role in severity uremic myopathy.

Adult↗
PubMed1997

[Protective role of carnitine in acetate metabolism of patients with uremia treated by hemodialysis].

In 25 patients with chronic renal failure treated by haemodialysis with acetate-37 mEq/l containing fluid, plasma free, total carnitine and acetate concentration before and after HD were assessed. The concentration of acetate was high-12 mmol/l in 4 patients in which carnitine concentration was low. In these patients the incidence of the so-called "dialysis intolerance" or "acetate intolerance" such as acute hypotension, nausea, vomiting and headache were increased. The correlation between the serum acetate level and carnitine level and the symptoms suggest that the acetate overload during acetate dialysis affects acetate metabolism and administration of L-carnitine decreases the amount of accumulated acyl-CoA in the cytosol, and consequently--the citrate cycle function increases and diminish the intolerance symptoms.

Acetates↗
PubMed1997

[Behavior of ventilation parameters, gas exchange and blood gases during hemodialysis (HD), in a traction during which the bicarbonate concentration in dialysis fluid is raised to a level of 60 m Eq/l].

In 9 patients with chronic renal failure treated by HD with bicarbonate-35 mEq/l containing fluid, investigations of minute ventilation, breathing patterns and blood gases were done during 5 sequential HD. During the standard HD-bicarbonate 35 mEq/l, the disturbances of minute ventilation, breathing patterns and blood gases did not appeared. During the standard HD session, between 60 to 75 minute of HD, the concentration of bicarbonate was increased to 60 mEq/l. Increased VCO2, PaCO2 and PvCO2 was observed during this 15 minutes in 45 HD sessions. Analysis of each HD in 9 patients showed that during 22 HD the values of VE, VA, VCO2 and PvCO2 were increased in 75 minute of HD compared to values obtained in 60 minute of HD. This group of HD we called responders. The different situation was during the 23 HD-non-responders. The values of PaCO2 and PvCO2 were increased in 75 minute of HD and VE and VA were decreased in this time. We conclude, that in the group of responders the increase of VE, VA, VCO2 and PvCO2 was the positive reaction of the breathing center to high values of PaCO2 and PvCO2. Decrease of VE observed in 23 HD-non-responders suggest the depressive influence of CO2 on respiratory muscles in patients with uremia.

Adult↗
PubMed1996

[Evaluation of skeletal muscle function during calcitriol treatment in patients dialyzed for uremia].

The purpose of the present study is to investigate whether Rocaltrol therapy in uremic patients undergoing dialysis treatment can improve muscle function. In 8 uramic patients (2--on CAPD, 6-on HD treatment) calcitriol (Rocaltrol, Roche) was given in the dosis at 1 mcg/day during 15 months. At the beginning of therapy and every month the following parameters were determined in serum: creatinine (Cr), calcium (Ca), phosphate (PO4) and parathyroid hormone (PTH). At the beginning and at the end of treatment the quantitative electromyography (EMG) was performed. We observed a slight increase of serum Cr during 15 months of treatment in 4 patients. Serum Ca, PO4 and PTH did not changed significantly. The EMG revealed abnormal polyphasic motor nerve unit potentials of brief durations, decrease in the amplitude and fibrillations potentials. The EMG findings did not change after Rocaltrol therapy, but all patients on physical examinations exhibited disappearance of clinical manifestations of uremic myopathy. In conclusion, our findings suggest that vit. D deficiency is one of the causes of uremic myopathy and a careful treatment with Rocaltrol can diminish muscle weakness in uremic patients.

Adult↗
PubMed1996

Does calcitriol therapy improve muscle function in uremic patients.

The purpose of the present study is to investigate whether calcitriol therapy in uremic patients undergoing dialysis treatment can improve muscle function. In 8 uremic patients [2 on continuous ambulatory peritoneal dialysis (CAPD), 6 on hemodialysis (HD) treatment], calcitriol (Calcitriol, Roche) was given in the dose of 1 microgram/day for 15 months. At the beginning of therapy and every month, the following parameters in serum were determined: creatinine (Cr), calcium (Ca), phosphate (P), and parathyroid hormone (PTH). At the beginning and at the end of treatment, quantitative electromyography (EMG) was performed. We observed a slight increase of serum Cr during 15 months of treatment in 4 patients. Serum Ca, P, and PTH did not change significantly. The EMG revealed abnormal polyphasic motor nerve unit potentials of brief durations, a decrease in the amplitude, and fibrillation potentials. The EMG findings did not change significantly after calcitriol therapy, but all patients on physical examinations exhibited the disappearance of clinical manifestations of uremic myopathy. In conclusion, our findings suggest that vitamin D deficiency is one of the causes of uremic myopathy and a careful treatment with calcitriol can diminish muscle weakness in uremic patients.

Adult↗
PubMed1996

[Myoneuropathy in patients with chronic renal failure treated with hemodialysis (HD) and intermittent peritoneal dialysis (IPD). I. Evaluation of myoelectric activity of selected skeletal muscles in patients with chronic renal failure treated with hemodialysis and intermittent peritoneal dialysis].

The aim of the study was the analysis of the sequence of electrophysiological changes occurring in the skeletal muscles in patients with chronic renal failure treated with hemodialysis (HD) and intermittent peritoneal dialysis (IPD). In 30 patients (10 treated with IPD-group I, 20 with HD-group II) the global electromyography (EMG) was determined in the muscles: pectoralis, obliqus and rectus abd., biceps brachii, thenar and hypothenar. The fatigue test was determined in the m. biceps brachii. The examinations were done twice during the 12 months of observations. The analysis of the material showed that myoelectrical activity of the examined muscles was significantly lower compared to a control group and did not changed during the 12 months of observations. The results of the fatigue test showed that in uremic patients the fatiguability of m. biceps brachii was significantly greater and was deeper after 12 months of observations. The analysis of the maximal inspiratory and expiratory pressure showed that respiratory muscles in uremic patients were weak. The results of the measurements the hand grip pressure showed that hand muscles were weak also.

Adult↗
PubMed1996

[Myoneuropathy in patients with chronic renal failure treated with hemodialysis (HD) and intermittent peritoneal dialysis (IPD). II. Sensory and motor nerve conduction velocity in patients with chronic renal failure treated with intermittent peritoneal dialysis and hemodialysis].

The aim of the study was the analysis of the sequence of electrophysiological changes occurring in the peripheral nerves in patients with chronic renal failure treated with hemodialysis and intermittent peritoneal dialysis. In 33 patients (21 treated with hemodialysis and in 12 treated with intermittent peritoneal dialysis) impulse conduction was determined in the motor and sensory fibers nerves. The examinations were done twice during 12 months of observations. The analysis of the material showed that sensory nerve conduction velocity was normal in all patients and did not changed during the study. Motor nerve conduction velocity was however significantly slower in all patients and did not changed during the study. The amplitude of sensory response was lower in all patients, the values of subjective and objective sensory response were higher compared to a control group. In all patient the quantitative EMG of m. abd. pollicis brevis was done. A signs of neurogenic atrophy were found in all patients. Only in one patients we observed signs of primary myopathy. There were no differences in the electrophysiological parameters in the patients treated with hemodialysis and with intermittent peritoneal dialysis.

Adult↗