Biomedical subjects

M Warner-Smith

Publications and source records attributed to M Warner-Smith.

5 recordsLinked to original sources

PubMed2006

Using cohort studies to estimate mortality among injecting drug users that is not attributable to AIDS.

BACKGROUND: Injecting drug use (IDU) and associated mortality appear to be increasing in many parts of the world. IDU is an important factor in HIV transmission. In estimating AIDS mortality attributable to IDU, it is important to take account of premature mortality rates from other causes to ensure that AIDS related mortality among injecting drug users (IDUs) is not overestimated. The current review provides estimates of the excess non-AIDS mortality among IDUs. METHOD: Searches were conducted with Medline, PsycINFO, and the Web of Science. The authors also searched reference lists of identified papers and an earlier literature review by English et al (1995). Crude mortality rates (CMRs) were derived from data on the number of deaths, period of follow up, and number of participants. In estimating the all-cause mortality, two rates were calculated: one that included all cohort studies identified in the search, and one that only included studies that reported on AIDS deaths in their cohort. This provided lower and upper mortality rates, respectively. RESULTS: The current paper derived weighted mortality rates based upon cohort studies that included 179 885 participants, 1,219,422 person-years of observation, and 16,593 deaths. The weighted crude AIDS mortality rate from studies that reported AIDS deaths was approximately 0.78% per annum. The median estimated non-AIDS mortality rate was 1.08% per annum. CONCLUSIONS: Illicit drug users have a greatly increased risk of premature death and mortality due to AIDS forms a significant part of that increased risk; it is, however, only part of that risk. Future work needs to examine mortality rates among IDUs in developing countries, and collect data on the relation between HIV and increased mortality due to all causes among this group.

Acquired Immunodeficiency Syndrome↗

PubMed2001

Heroin overdose: causes and consequences.

Over the past decade fatal opioid overdose has emerged as a major public health issue internationally. This paper examines the risk factors for overdose from a biomedical perspective. While significant risk factors for opioid overdose fatality are well recognized, the mechanism of fatal overdose remains unclear. Losses of tolerance and concomitant use of alcohol and other CNS depressants clearly play a major role in fatality; however, such risk factors do not account for the strong age and gender patterns observed consistently among victims of overdose. There is evidence that systemic disease may be more prevalent in users at greatest risk of overdose. We hypothesize that pulmonary and hepatic dysfunction resulting from such disease may increase susceptibility to both fatal and non-fatal overdose. Sequelae of non-fatal overdose are recognized in the clinical literature but few epidemiological data exist describing the burden of morbidity arising from such sequelae. The potential for overdose to cause persisting morbidity is reviewed.

Adolescent↗

PubMed2001

Challenges and approaches to estimating mortality attributable to the use of selected illicit drugs.

A number of unique challenges are faced when attempting to estimate mortality attributable to illicit drugs. The hidden nature of illicit drug use creates difficulties in quantifying the prevalence of such use; identifying adverse health effects associated with exposure, and calculating the risk of these effects. The use of cohort studies of drug users allows the identification of causes of mortality associated with drug use and the determination of the risk of these causes. This risk estimate can then be used in conjunction with estimates of the prevalence of drug use to extrapolate the burden of mortality. We identify a number of such studies and present some solutions to the major challenges faced when attempting to estimate the global burden of mortality attributable to illicit drug use.

Cohort Studies↗

PubMed2000

Dissemination of responsible service of alcohol initiatives to rugby league clubs.

OBJECTIVES: To determine the acceptability of intervention strategies that increase the responsible service of alcohol by non-metropolitan rugby league clubs. METHOD: Rugby league clubs were provided an information kit and advice by local public health workers, police and a lead agency regarding their responsible service of alcohol practices. Rugby League clubs and public health workers completed an acceptability survey at the conclusion of the study. RESULTS: Data were collected from 160 contactable clubs (100% consent) and 12 of 14 participating public health workers. Almost all clubs reported of contact with the lead agency, public health workers and police to be acceptable. Fifty-nine percent of clubs reported contact with public health workers to be useful. One-third of the public health workers considered that they were not the most suitable professional group to be involved in delivering the intervention. CONCLUSIONS: In spite of a suggested culture of harmful alcohol consumption among rugby league participants and spectators, non-metropolitan rugby league clubs appear receptive to public health strategies that increase their responsible service of alcohol. IMPLICATIONS: The ability of the public health sector to meet this opportunity appears limited, and may require additional strategies to increase the capacity of public health workers to develop/deliver inter-sectorial interventions in this setting.

Adolescent↗

PubMed1999

Satisfaction with the process of lead remediation in an urban Australian community.

OBJECTIVE: To assess householders' satisfaction with the process of residential lead abatement in an urban Australian population. METHOD: The study area consisted of suburbs immediately surrounding a lead-related industry on Australia's east coast. Nineteen of 20 remediated households in the study area agreed to participate in the survey. One trained interviewer conducted semi-structured qualitative interviews with one 'key' person from each remediated household. Participants were asked for their personal views as well as general household views about the rationale for, process and results of lead remediation. RESULTS: The 19 households varied from three to seven people and contained 1-5 children (16 years or under). The opinions of residents of remediated households were polarised, with the majority being either greatly satisfied or greatly dissatisfied with the process. Level of satisfaction was clearly linked to perceived quality of the remediation works. CONCLUSIONS: Satisfaction with household lead remediation could be improved by ensuring effective communication between all parties; providing clear, simple, but detailed information about the remediation works to be undertaken on each household; providing timely support for householders when problems arise; and ensuring that all contractors are skilled, reputable and have acceptable communication skills.

Adolescent↗