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Biomedical subjects

M Watts

Publications and source records attributed to M Watts.

At least 55 records · Page 3Linked to original sources
PubMed1990

Complement-fixing antibodies to sympathetic and parasympathetic tissues in IDDM. Autonomic brake index and heart-rate variation.

We describe herein complement-fixing anti-adrenal medullary (CF-ADM) and anti-sympathetic ganglia (CF-SG) antibodies in insulin-dependent diabetes mellitus (IDDM). This study describes complement-fixing anti-vagus (CF-V) nerve antibodies and their relationship to the cardiovascular autonomic brake index (a measure of transient decrease in heart rate during the 1st min after a tilt), and R-R interval variation with deep breathing. CF-V was detectable in 7 of 83 (8.4%) subjects with IDDM aged 1.5-65.5 yr (mean +/- SE 28.7 +/- 1.8 yr) and duration of diabetes 0-47 yr (11.8 +/- 1.4 yr). Seventy-six nondiabetic subjects (aged 10-65 yr) all had negative CF-V scores. CF-V scores correlated with CF-ADM (0-16 yr of IDDM, r = 0.61, P less than 0.0001) and CF-SG (r = 0.39, P less than 0.05). Seventy IDDM subjects (aged 28 +/- 5 yr, duration of diabetes 17 +/- 3 yr) without proteinuria or proliferative retinopathy were screened for CF-ADM, CF-SG, and CF-V antibodies. Five of 70 (7.1%) had CF-SG only (negative for CF-ADM and CF-V). Brake indices ranged from 14.7 to 51.3 (37.3 +/- 6.9). Three of 70 (4.2%) had CF-ADM only, with brake indices from 26.9 to 45.1 (32.9 +/- 6.1). Four of 70 (5.7%) had CF-V antibodies only, with brake indices of 12.7-17.3 (15.1 +/- 1.1). Subjects with CF-SG or CF-ADM (anti-sympathetic) had higher brake indices than subjects with CF-V (anti-parasympathetic) antibodies (P less than 0.03).(ABSTRACT TRUNCATED AT 250 WORDS)

Adolescent↗
PubMed1989

Screening for ischaemic heart disease risk factors at a health fair: low attendance by those at highest risk.

Among people attending a heart disease screening project at a Health Fair in Sheffield, only 22 of 425 (5.2%) lived in areas with more than 25% of the population belonging to social classes IV or V. The incidence of heart disease is known to be particularly high in these areas, where 15.1% of the total population live. By analysis of the attendance rates from districts other than those immediately adjacent to the site of the Health Fair, we found that the strength of this inverse correlation increased, suggesting that the problems of access are probably greater for people living in deprived areas than for others.

Coronary Disease↗
PubMed1989

Anti-sympathetic ganglia antibodies and postural blood pressure in IDDM subjects of varying duration and patients at high risk of developing IDDM.

We examined the sera of 94 subjects with insulin-dependent diabetes mellitus (IDDM) for the presence of complement-fixing sympathetic ganglia (CF-SG) antibodies. In a cross-sectional analysis (duration 0-43 yr), 22% had detectable CF-SG antibodies. Subjects at high risk for IDDM were also studied. Four groups were studied: group 1 (aged 4-64 yr) islet cell antibody-positive (ICA+) prediabetic subjects, 10 of 19 (53%) were CF-SG+; group 2 (aged 6-14 yr) ICA- prediabetic subjects (first-degree relatives of IDDM subjects with either transient hyperglycemia, impaired oral glucose tolerance, and/or first-phase insulin release after intravenous glucose tolerance testing), 4 of 9 (44%) were CF-SG+ (2 of the 4 ICA- CF-SG+ subjects have progressed to IDDM); group 3 (aged 1.5-43 yr) ICA+ IDDM subjects (less than or equal to 1 yr duration) 6 of 10 (60%) were CF-SG+; and group 4 (aged 8-59 yr) ICA- IDDM subjects (less than or equal to 1 yr duration), 2 of 11 (18%) were CF-SG+. All groups had increased CF-SG compared with controls. Postural blood pressure and simultaneous CF-SG antibody measurements were performed in 28 IDDM subjects. The drop in systolic blood pressure was greater in the CF-SG+ subjects (P less than .05), and the frequency of CF-SG was greater in the mean to -2SD group (P less than .03) when data were analyzed within mean +/- 2SD of the normal blood pressure response.

Adolescent↗
PubMed1989

Resistance to lethal levels of diethylstilboestrol in the nematode Caenorhabditis elegans.

Concentrations of diethylstilboestrol (DES) exceeding 100 microM are normally fatal to all living tissues due to inhibition of cell division and other cell processes. However, in Caenorhabditis elegans, with increasing levels of DES, there was an observed decrease in fertility and fecundity (99%), although a small percentage of the population (1%) survived concentrations as high as 400 microM DES. Uptake studies, using tritiated-DES liquid scintillation and ELISA analysis, revealed that uptake exhibited saturation at 100 microM and levels exceeding 100 microM resulted in no further biological response. Thus, ultrastructural morphology and viability of the organism was unchanged after the DES saturation point.

Animals↗
PubMed1988

The haematological values of European badgers (Meles meles) in health and in the course of tuberculosis infection.

Captive, healthy, adult badgers have blood containing haemoglobin at 13.3 g/dl, and 8.4 x 10(12)/l red cells with an MCV of 46.2 fl and an MCH of 15.6 pg. They have 5.1 x 10(9) white cells/l of which 3.29 x 10(9) are polymorphs, 1.49 x 10(9) are lymphocytes, 0.26 x 10(9) are monocytes, 0.07 x 10(9) are eosinophils and 0.01 x 10(9) are basophils. These values are somewhat less in adult animals just trapped from the wild, and are lower still in wild cubs. Changes associated with tuberculosis are a rise, and then a fall in red blood count and white blood count, an increase in the proportion of polymorphs and monocytes and a fall in lymphocytes late in the disease. This picture is similar to that seen in widespread, disseminated, tuberculin negative, tuberculosis in humans, a type of disease similar to that occurring in many badgers. BCG vaccination of badgers did not produce any measurable change in the blood picture.

Animals↗
PubMed1987

Effect of socioeconomic status on survival from cervical cancer in Sheffield.

The relation between age at registration, socioeconomic status, and survival from cervical cancer for women resident in Sheffield was examined using the 556 such cases registered with the Trent Cancer Registry from 1971 to 1984. The address and electoral ward at registration were used to categorize the socioeconomic status of 99% of the women. Five year survival for all cases was 49%, increasing age having a predictable deleterious effect. Socioeconomic status seemed to have little effect on survival, especially when the covarying effect of age had been taken into account. It is hypothesised that the survival inequalities for cervical cancer demonstrated elsewhere have largely been prevented in Sheffield by good access to effective treatment from the National Health Service.

Age Factors↗