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M Wehr

Publications and source records attributed to M Wehr.

50 records · Page 3Linked to original sources
PubMed1983

Value of QRS alteration in determining the site of origin of narrow QRS supraventricular tachycardia.

To determine the value of alternation of QRS morphology in determining the site of origin of sustained narrow QRS supraventricular tachycardia (SVT), we retrospectively studied 163 distinct tachycardias in 161 patients (ages 4 to 91 years) in whom the site of origin of SVT was proven by intracardiac electrophysiologic study. Sustained SVT was defined as lasting longer than 30 sec. Narrow QRS was defined as QRS width less than 0.12 sec. Atrial fibrillation and flutter were excluded. The presence or absence of QRS alternation was judged at least 10 sec after initiation of SVT. Circus movement tachycardia with anterograde AV node conduction and a retrograde accessory AV pathway was seen in 89 patients (58 with Wolff-Parkinson-White syndrome, 31 with concealed accessory pathway); intra-AV nodal reentrant tachycardia (AVNT) was present in 57 cases, and 17 tachycardias were atrial in origin. QRS alternation was present in 36 of 163 cases (22%). In only eight of these 36 did RR interval length alternation accompany alternation in QRS morphology. Thirty-three of 36 (92%) tachycardias with QRS alternation were circus movement tachycardias. Two were atrial in origin and one was AVNT. We conclude that the presence of QRS alternation during sustained narrow QRS SVT is highly indicative of a retrograde accessory AV pathway in the tachycardia circuit.

Adolescent↗
PubMed1982

[Heart function during postoperative high-voltage therapy in female patients with left-sided breast cancer].

Systolic time intervals according the method of Weissler were measured in nine females (mean age: 55.1 years) with mammary carcinoma on the left, prior to, during and 3 months after postoperative radiation therapy. The average load to the anterior cardiac wall amounted to 36 Gy. We found a reversible statistically highly significant decrease of left ventricular function (increase of PEP/LVET) during radiation therapy, which seems to be related to a radiation-induced acute pancarditis known from animal experiments.

Aged↗
PubMed1982

[Arrhythmias in poisoning with tricyclic antidepressive agents. Successful treatment with physostigmine and sodium].

A 26-year-old female patient was admitted 30 minutes after suicidal poisoning with 750 mg amitriptyline (Saroten), 4800 mg dibenzepine (Noveril retard) and 2100 mg thioridazine (Melleril). Life threatening disturbances of cardiac rhythm occurred in addition to coma, pulmonary insufficiency requiring assisted ventilation, and hypotension. Physostigmine only caused temporary improvement and the arrhythmias only resolved completely after additional administration of NaCl.

Amitriptyline↗
PubMed1982

[An electrocardiographic study of cardiac damage following post-operative radiation in patients with mammary carcinoma on the left (author's transl)].

Systematic ECG-analysis were performed in 13 patients (mean age 55.1 years) with mammary carcinoma on the left, prior to, during, and 4 months after postoperative radiation therapy. Treatment was done with a gammatron, the average load to the anterior cardiac wall amounted to 36 Gy. All patients exhibited ST-T segment changes, flat, isoelectric or coronary negative T-waves in the precordial leads demonstrating radiation-induced perimyocarditis. Prolongation of QT-interval corrected with Bazett's formula (QTc) was observed in 6 patients showing myocardial damage. Sinus tachycardia in 9 patients and lower voltage in 3 patients gave a hint to early appearance of pericardial effusions. Pulmonary P-waves in 6 patients and shift of QRS-axis to the right in 5 patients demonstrated early damage of the right heart. Clinical deterioration could not be seen in any patient.

Breast Neoplasms↗
PubMed1981

[Assessment of the course of chronic hepatic encephalopathy. Comparison of various measurements with special reference to the trail-making test].

In eight patients with hepatic cirrhosis and chronic hepatic encephalopathy stage I and II the following measurements were performed in parallel on 58 occasions over eight months: number connection test, time-linked orientation, presence of liver flap, arithmetical test, handwriting sample, electroencephalogram, and venous blood ammonia level. The number connection test correlated significantly with all other parameters apart from the ammonia level. The number connection test had the highest correlation coefficient. The electroencephalogram showed a significant but only weak correlation with each of the other parameters. Results of the arithmetical test, time-linked orientation and handwriting correlated significantly with each other and with the other tests with the exception of the ammonia level. In contrast to the EEG multiple linear correlation of all parameters allowed accurate prediction of the early stage of chronic hepatic encephalopathy if the number of connection test is taken as the measure of the stage. The number of connection test is easy to perform and shows accurate reproducibility. It gives a value as to the severity of onsetting chronic hepatic encephalopathy which is independent of the tester.

Aged↗
PubMed1980

[Granulocytopenia with cimetidine therapy (author's transl)].

In a 38-year-old patient with alcoholic liver cirrhosis and haemorrhage from a gastric ulcer, granulocytopenia occurred during cimetidine treatment. It was reversible after therapy was stopped. The platelet count also fell during cimetidine and a reduction of megakaryocytes was found in the bone marrow.

Adult↗
PubMed1980

[Abnormal pacing following defibrillation - exit block after microdislocation of the electrode (author's transl)].

Two days after a 52-year-old patient with coronary heart disease (third degree-av-block and ventricular rhythm, permanent pacemaker treatment) had a pacemaker replacement, bradycardia and pacemaker exit block occurred. After defibrillation with 300 Ws pacemaker for spontaneous ventricular fibrillation, entrance block and new fibrillation were observed. Further defibrillation lead to raising the frequency of the pacemaker and to abnormal stimulation, which in turn triggered irreversibly ventricular fibrillation and the death of the patient. Autopsy showed a micro-dislocation of the electrode and the pacemaker showed a defect of the Zener diode and abnormal stimulation with 4000 Hz ith a pulse width of 240-275 ms and a pulse interval of 1010 ms. We like to point out the importance of the stimulation threshold measurement following pacemaker replacement because of early diagnosis of electrode dislocation that can lead to ventricular fibrillation. We also describe the complication of defibrillation with a pacemaker patient and give advice for prevention of its occurrence.

Bradycardia↗
PubMed1977

[Coronarangiographic study on the trifurcation branch of the left coronary artery postmortem (author's transl)].

In 141 human hearts by means of coronary angiography post mortem 72 (51.1%) were found with bifurcation and 63 (44.7%) with trifurcation of the left coronary artery. In 6 hearts there was a fourfold division of the left main coronary artery. The supplying areas of the trifurcation branch was located in the left anterior or lateral ventricular wall. Its size varied in a wide range. Partly it belonged to the supplying areas of the anterior descending, partly to the left circumflex branch.

Adolescent↗
PubMedDate not supplied

Spatiotemporal structure of olfactory inputs to the mushroom bodies.

A requirement to understand mushroom body (MB) function is to characterize the operations (or transformations) that they impose on incoming signals. Understanding the nature of these integrative operations requires an understanding of the inputs from other brain areas. By inputs we mean not only the anatomical pathways leading to the MBs, but also the dynamic structure of the inflow of sensory (and other) signals. Neurons are complex, capacitative, and generally nonlinear devices that transform barrages of neurochemical packets into electrical waveforms. Their modes of operation are intrinsically time dependent and therefore, their functions or roles in a circuit cannot be inferred only from structural data. Thanks to elegant anatomical, behavioral, genetic, and molecular (for review, see Crittenden et al. 1998; Hammer and Menzel 1998; Heisenberg 1998; Wolf et al. 1998) studies, there is convincing evidence that MB circuits are involved, at least in fruit flies and honeybees, in some forms of odor integration and learning. In vivo electrophysiological studies of MB neurons, however, are rare and mainly restricted to individual (or small populations of) so-called extrinsic neurons, that is, those whose processes link MBs with other brain areas (Schildberger 1983, 1984; Homberg 1984; Hammer 1993; Mauelshagen 1993; Li and Strausfeld 1997). Kaulen et al. (1984) examined extracellular potentials in the MBs of bees, using current source density analysis, and more recently, Laurent and Naraghi (1994) provided a description of stimulus-evoked activity in Kenyon cells (KCs), the intrinsic neurons of the MBs, using intracellular recordings. In this short review we will summarize the recent results from our laboratory in an attempt to provide a description of the spatiotemporal structure of olfactory inputs to the MBs and their intrinsic neurons. We will focus only on the encoding of odor quality. We will then speculate on the possible role of MB circuits for olfactory processing.

Animals↗