[Study of ulcerative gastroduodenal lesions observed during 11,978 consecutive autopsies (1950-1964)].
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Biomedical subjects
Publications and source records attributed to M Weill-Bousson.
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In a general review of the different varieties of the intestinal polyposes, emphasis is laid upon the main three types of the so-called "genetic polyposes" (juvenile polyposis, Peutz-Jeghers syndrome, and adenomatous polyposis) because of their peculiar interest concerning the pathological diagnosis, prognosis and genetic background. A correct histological diagnosis is of the utmost importance before an appropriated treatment can be initiated.
Cholecystoses is a generic term introduced by Colesson and Jutras for a group of abnormalities of the gallbladder that appear to be separate from inflammatory diseases. Cholecystoses imply a benign proliferation of normal tissue elements, whereas cholecystosis indicates a pathologic process that is distinct from inflammation. 1 072 cholecystectomies were examined. 180 cholecystoses were diagnosed, 162 were associated with gallstones. There was no difference concerning the clinical symptom between cholecystoses and cholelithiasis. Radiological study confirms and clarifies the nature and character of these gallbladder lesions. In the histological examination 49,4 per cent of the cases were cholesterolosis, 2,9 per cent polyposis and 47,7 per cent adenomatosis. The treatment of cholecystoses is first and foremost medical, exception in case of calcareous and porcelain gallbladders. Surgery is only indicated in cases in which medical treatment is unsuccessful and when a cancerous degeneration is suspected.
We report the case of a 13-year-old girl who presented mixed polyposis coli and gastric polyps. The rectal and colonic polyps were of the adenomatous and hamartomatous type (i. e. juvenile and Peutz-Jeghers polyps) without any intermediate features; in the stomach, the polyps were of the hyperplastic type. Microadenomas of the appendix and lymphoid hyperplasia of the ileum were also found. The karyotype was normal and the HLA group was A2 B12. No family history of polyps was discovered. To our knowledge no such case (complex polyposis) has been previously described. The present findings suggest that the usual pathological classification of polyposis may be arbitrary and that various pathological types may represent different aspects of the same spectrum of disease. Absence of "intermediate" polyps rule out the hypothesis of the sequence "hyperplastic polyp-juvenile polyp-adenoma".