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Biomedical subjects

M Weissman

Publications and source records attributed to M Weissman.

At least 37 records · Page 2Linked to original sources

The assessment of lifetime psychopathology: a comparison of two interviewing styles.

A structured respondent-based version of the SADS-L interview was compared with a semi-structured investigator-based version of the same interview in terms of efficiency in assessing lifetime psychopathology. There was substantial agreement across most Research Diagnostic Criteria (RDC) categories, but there was less agreement on the rating of symptoms. The implications of these similarities and differences between the techniques are discussed.

Adult↗

Anxiety and alcoholism.

The prevalence and the co-occurrence of anxiety disorders and alcoholism in individuals, families, and the general population have been documented in both epidemiologic and clinical investigations. In patients who fulfill the criteria for one of those conditions, clinicians should consider the possibility of the presence of the other disorder--currently, at a previous time, or at some point in the future. A lifetime history of alcohol abuse and anxiety disorders obtained from both the patient and the family members may assist in determining the appropriate treatment.

Alcoholism↗

Determination of molecular weights by fluctuation spectroscopy: application to DNA.

A method for determining molecular weights of macromolecules by measuring spontaneous concentration fluctuations is described. The method is absolute, rapid, and requires no shearing forces on the molecules. We have applied this technique to the determination of molecular weight of DNA molecules. The molecular weight values obtained for T2 phage DNA (1.14 X 10(8)) and replicating Escherichia coli DNA (3.9 X 10(9)) agree with previous results. By monitoring individual molecules, an estimate of the molecular weight of nuclei and individual chromosomal DNA molecules of Drosophila melanogaster was obtained.

Animals↗

Utilization review of treatment for suicide attempters.

The authors describe an effort to develop criteria for utilization review of treatment for suicide attempters. Explicit criteria proposed by a panel of experts as essential determinants for hospitalization of these patients were compared with actual clinical practice. It was found that according to the experts' criteria (which were operationalized into rating assessments), over half of the outpatient sample should have been hospitalized. After multiple regression analysis was carried out on the criteria, however, four predictors showed that only 20 percent of the outpatients should have been hospitalized. The authors discuss the issues these findings raise about the criteria of the experts, their utility for research, their validity, and their implications for utilization review.

Decision Making↗

Participation in therapy. A study of attendance patterns in depressed outpatients.

The attendance patterns of 36 predominantly lower class, depressed women receiving outpatient psychotherapy were studied to determine the actual amount and frequency of therapy received in an 8-month period. At the initiation of therapy, the majority of patients expressed either neutral or negative attitudes to therapy. Contrary to the usually held belief that indifferent attitudes to therapy coupled with the patients' low socioeconomic status augured poorly for the patients' continuatioin therapy, we found that the sample studies attended regularly and remained in therapy until the end of the prescribed 8-month period. Missed appointments occurred rarely and were usually preceded by cancellations. The majority of therapy sessions were with patients, but provisions were available for the involvement of spouses and other relatives where indicated. It is suggested that the time-limited nature of therapy, the delineation of stort term, realistically attainable goals, and the vigorous outreach techniques by the therapists may have contributed to the unexpectedly high therapy attendance.

Adult↗

Fluctuation spectroscopy: determination of chemical reaction kinetics from the frequency spectrum of fluctuations.

The kinetic parameters of a chemical reaction were obtained from analysis of the frequency spectrum of the fluctuations (i.e., "noise") in the concentrations of the reactants. In "fluctuation spectroscopy," no external perturbation is applied and the system remains in macroscopic chemical equilibrium during the experiment. Results obtained by this method for the dissociation reaction of beryllium sulfate agree well with those obtained by relaxation methods in which the approach to equilibrium is analyzed. Other noise sources not originating from a chemical reaction were observed and analyzed. The most prominent of these arose from the flow of an electrolyte through a capillary. The method of fluctuation spectroscopy should be applicable to problems of physical, chemical, and biological interest.

Journal Article↗