PubMed Health⌕ Search

Biomedical subjects

M Wender

Publications and source records attributed to M Wender.

At least 19 recordsLinked to original sources
PubMed1992

Electron paramagnetic resonance analysis of heavy metals in the aging human brain.

Electron paramagnetic studies of heavy metals were performed with the use of a Radiopan spectrometer on autopsy material of 5 aged patients (mean age 80.2 years) and 15 control patients (mean age 29 years). The obtained results lead to the following conclusions: 1. The aging brain is characterized by a tendency to decrease in concentration of isolated Cu2+ ions, and a marked decrease in concentration of Fe3+ ions as well as of free radicals, whereas the concentration of Cu2+ clusters is significantly increased. 2. The cases showing both arteriosclerotic and senile degenerative changes are characterized by higher concentrations of Cu2+ clusters than the brains with dominance of the arteriosclerotic process, whereas the concentrations of isolated Cu2+ and Fe3+ ions as well as that of free radicals do not differ between the two subgroups. 3. The diminished concentrations of Cu2+ and Fe3+ ions and free radicals observed in brains of old persons and concomitant with increased concentration of multi-ion aggregates (clusters), more marked in cases of senile atrophy of Alzheimer type, seem to result from some slow-down of metabolic processes in the aging brain.

Adult↗
PubMed1992

[Early changes in the visual system in subacute sclerosing panencephalitis].

This paper presents our observations of changes in the visual system in the early period of SSPE in the group of 23 children at the age of 3 to 17 years (18 boys and 5 girls). The most frequent changes were papillary stasis (9 patients). Decreased visual acuity with no changes in the optic fundus or with chorioretinitis and simple atrophy of the optic nerve were observed in 8 children. Convergent squint, visual hallucinations and visual agnosia were additional symptoms in single cases. Changes in the visual system which appeared in early period of the disease as single clinical symptom usually create serious diagnostic problems. The greatest problem appeared when papillary stasis coexisted with other symptoms of increased intracranial pressure. Neuroradiological examinations were decisive in these cases. Diagnosis of SSPE was confirmed by further course of the disease and others additional and typical results.

Adolescent↗
PubMed1991

Myelin proteins in aging human brain.

Autopsy material of 13 persons who died between 70 and 89 yrs old and of patients who died between 27 and 44 yrs old was studied. White matter of temporal, parietal, and occipital lobes was investigated using histological and biochemical methods. According to results of neuropathological studies, the material of aged patients was divided into two subgroups: (a) brains with vascular changes only and (b) patients with senile atrophy of Alzheimer type. Chemical changes found in all studied brain lobes included a mild decrease in Wolfgram protein content with reciprocal increase in large basic protein content, together with a marked decrease in myelin yield. The abovementioned chemical changes were almost identical whether they were only vascular changes or whether senile atrophy of Alzheimer type was also present. It seems, therefore, that the degeneration of vessels is the decisive factor in the pathogenetic mechanism of myelin lesions in the aged brain.

Adult↗
PubMed1991

Myelin lipids in ischemic stroke.

Slices of ischemic focus (infarct area) and of the contralateral frontal lobe were submitted to histological and biochemical studies. The obtained results indicate that in stroke cases the necrotic focus as well as contralateral brain hemisphere are characterized by a marked decrease of cholesterol and cerebrosides content and an increase of lysophosphatidylcholine and cholesterol esters in the myelin fraction. We conclude that ischemia as well as the degenerative aging process are both responsible for the abnormal lipid pattern in the myelin of the white matter in stroke cases. The long lasting hypoxia resulting from cerebral vessel atheromatosis contributes to biochemical changes in the myelin of the apparently healthy white matter of the contralateral hemisphere in brain infarction.

Acute Disease↗
PubMed1990

Pattern of myelin proteins in moderate hypoxia.

Myelin proteins isolated from the brain of Wistar rats subjected to moderate hypoxia (7% of oxygen in a respiration gaseous mixture) for 30 min were investigated. Among the various protein fractions Wolfgram protein happened to be most markedly affected, demonstrating considerably lowered percentages in all experimental groups, starting from 24 h after hypoxia. Our findings compared with those obtained in other experimental conditions lead to the conclusion that changes in the myelin protein pattern are characteristic for particular morbid processes evoked by various pathogenic factors. The demyelination is concomitant with severe loss of basic proteins, whereas myelin lesions of other types are connected with changes in protein of higher molecular mass.

Animals↗
PubMed1990

Epidemilogy of stroke in the Poznań district of Poland.

The incidence of cerebrovascular disease was established in the Poznań district in Poland for 1985. Mortality from cerebrovascular disease during this year was compared with mortality during 1977. The autopsy material from the years 1925 to 1985 was analyzed to differentiate ischemic from hemorrhagic stroke. The incidence of stroke was 198.3 per 100,000 inhabitants greater than 20 years of age. Mortality from cerebrovascular disease decreased significantly in both males and females from 1977 to 1985. Analysis of the pattern of cerebrovascular disease in the autopsy material from 1925 to 1965 demonstrated an overwhelming percentage of hemorrhagic stroke. In the years that followed, an inversion was noticed in the ratio of ischemic to hemorrhagic stroke. It should be assumed that the growing efficacy of antihypertensive therapy largely explains the decreasing incidence of stroke-induced mortality.

Adult↗
PubMed1990

[Epidemiology of Alzheimer's disease in the selected region of Wielkopolska (town and commune Steszew)].

An epidemiological survey of Alzheimer's disease (senile dementia of Alzheimer type) was conducted on the territory of town and commune Steszew, lying in the Poznań district, with a population of 13,023 on the appointed day, December 31, 1988. Clinical diagnosis was established by detailed anamnesis, neurological, general and psychological examinations. Also a clinical questionnaire containing ischemic scale after Hachinski et al., (1975) was evaluated. The detected overall prevalence rate of Alzheimer's dementia on the appointed day (December 31, 1988) was 1105.7 per 100 thousand population, whereas in the group of persons over 65 years was 10059.2 per 100 thousand. The prevalence rate of severe cases of Alzheimer's disease was established in the group of population over 65 year on 2662.7 per 100 thousand. The detected overall incidence rate of Alzheimer's disease in the year 1988 was in the age class 45-65 years 201.5 per 100 thousand, and in the group over 65 years 2588.8 per 100 thousand. The obtained results of our investigations in the population of western Poland are in the lower part of dispersion of the epidemiologic data on Alzheimer's disease in the world scale. The results indicate that too rarely is diagnosed Alzheimer's disease as a cause of dementia in elderly people, and too often the cerebrovascular disease. The high prevalence rate of demented people in senility indicates on great importance of organization of Inpatients Senior Clinics in which a part of those people shall find a place.

Age Factors↗
PubMed1989

Influence of experimental hypoxia on content and composition of free fatty acids in cerebral white matter.

The content and spectrum of free fatty acids were studied in the cerebral white matter, on Wistar rats exposed to acute hypoxia (2% of oxygen in a respiratory mixture) for 3 min. The total content of fatty acids, especially of tetraenoic ones, rose sharply already 4 min after hypoxia and persisted elevated even 2 months after the hypoxia. The results showed that the degradation of phospholipids-containing biological membranes in the nervous tissue of the white matter starts immediately after hypoxia, and is continued for months.

Animals↗
PubMed1989

[Epidemiology of Parkinson disease in the Pozna'n province].

The authors analyzed the prevalence and incidence of parkinsonism in the Poznań region. The research led to the following conclusions: 1. Incidence of parkinsonism in the Poznań region amounts to 12.6 per 100,000 of population, which is the middle value of scatter in the investigation on a world-scale. The prevalence of the disease--65.9 per 100,000--is the lower range of values found in many countries of the world. This seems to point to a shorter survival time of patients with parkinsonism in our country. 2. Among various age groups, the highest incidence and prevalence of parkinsonism is found in the age groups of 70-79 and 80-89, with slightly higher prevalence rates among males. 3. The authors found in the Poznań region irregular prevalence of parkinsonism, that is the existence of small focuses of the disease, which seems to depend on unfavourable genetic factors existing in those places.

Adult↗
PubMed1988

Myelin lipids in aging human brain.

The studies were performed on autopsy material of 18 patients who died between the ages of 70-89 y, and of 5 patients who died between 23-44 ys of age. White matter of the frontal lobe and of oerebellum was submitted for histological and biochemical analysis. The neuropathological data provided a rationale for dividing the material into two subgroups: one including patients mainly with vascular changes in the brain, and the other consisting of patients with senile atrophy of the Alzheimer type. Chemical alterations noted both in frontal lobe and in cerebellum were an increase in lysophosphatidylcholine content and a marked decrease in myelin yield. Additionally, in cerebellum a decrease in sulphatide content was observed. The chemical results were almost identical in the two subgroups of patients, although they differ in neuropathological patterns of lesions. It is emphasized that the general decrease in myelin yield as well as some minor changes in myelin lipid pattern seem to be a sign of aging and are not connected with atrophy of the Alzheimer type.

Adult↗
PubMed1988

Myelin lipids of the rat brain in experimental hypoxia.

The pattern of cerebral myelin lipids was studied in Wistar rats exposed to mild hypoxia (7% of oxygen in a respiratory mixture) for 30 min. The most pronounced change involved a marked increase in cholesterol esters and lysophosphatidylcholine content in the myelin fraction. The results obtained indicate that mild hypoxia induces a lesion of myelin membranes but does not provoke the reaction of lymphocytes and macrophages, which by production of myelinolytic factors, evoke demyelination.

Animals↗