PubMed Health⌕ Search

Biomedical subjects

M Wesson

Publications and source records attributed to M Wesson.

10 recordsLinked to original sources
PubMed1994

5-Methyltetrahydrofolate level in the serum of depressed subjects and its relationship to the outcome of ECT.

Serum 5-MeTHF levels are reported in 26 subjects, before and after completing a course of ECT, and compared to 21 healthy volunteers. 5-MeTHF levels of depressed subjects were significantly lower than controls before and after ECT. There was no difference in 5-MeTHF levels between ECT responders and non-responders but folate deficiency was related to severity of depression before ECT. Serum 5-MeTHF was not related to treatment response and values remained markedly low even after a good response to treatment.

Aged↗
PubMed1991

Tolerance of normal tissue to therapeutic irradiation.

The importance of knowledge on tolerance of normal tissue organs to irradiation by radiation oncologists cannot be overemphasized. Unfortunately, current knowledge is less than adequate. With the increasing use of 3-D treatment planning and dose delivery, this issue, particularly volumetric information, will become even more critical. As a part of the NCI contract N01 CM-47316, a task force, chaired by the primary author, was formed and an extensive literature search was carried out to address this issue. In this issue. In this manuscript we present the updated information on tolerance of normal tissues of concern in the protocols of this contract, based on available data, with a special emphasis on partial volume effects. Due to a lack of precise and comprehensive data base, opinions and experience of the clinicians from four universities involved in the contract have also been contributory. Obviously, this is not and cannot be a comprehensive work, which is beyond the scope of this contract.

Bone and Bones↗
PubMed1991

Optometric findings in the fragile X syndrome.

Fragile X syndrome (fra X) is one of the most significant discoveries in the area of mental retardation in the past 2 decades. Although hundreds of articles and two text-books have been written on the subject, only two studies have been published in the ophthalmic literature. This paper provides a brief review of the syndrome and reports on the ocular findings of 30 subjects with this genetic abnormality. We found that 30% of the subjects exhibited strabismus. Of those with strabismus, 70% were esotropes. Fifty-nine percent of the eyes evaluated (N = 58) showed hyperopia of +1.00 D or greater, 17% myopia of -1.00 D or greater, and 22% had at least 1.00 D of astigmatism. Major ocular health abnormalities were not identified in any of our subjects. The optometrist, as the primary eye care provider, should diagnose and treat these oculo-visual dysfunctions.

Adolescent↗
PubMed1990

The most highly amphiphilic alpha-helices include two amino acid segments in human immunodeficiency virus glycoprotein 41.

A search for highly amphiphilic alpha-helices has been made in a data base of protein sequences, using the helical hydrophobic moment as a criterion of amphiphilicity. The protein segments of largest hydrophobic moment have been analyzed. For the segments whose structures are known, they are in fact alpha-helices. Two of the segments having very large hydrophobic moments are from the smaller C-terminal portion of the human immunodeficiency virus (HIV) envelope glycoprotein gp41. Also, among segments having large hydrophobic moments, but not among the most extreme, are lytic peptides such as melittin. Melittin seeks surfaces between polar and apolar phases, including the membrane-water interface. It is conceivable that the gp41 segments of extreme hydrophobic moment may participate in one of the membrane-related functions of the HIV virus.

Amino Acid Sequence↗
PubMed1988

Scleral fixation of a subluxated posterior chamber intraocular lens.

A surgical technique for the treatment of a subluxated intraocular lens is described. It consists of a scleral incision 2 mm from the limbus, hooking the loop haptic of the implant into the scleral wound, and imbricating the loop into the sclera for permanent fixation. Four eyes in which this technique was applied successfully are reported.

Adult↗
PubMed1986

Disparity vergence dynamics and fixation disparity.

The initial velocity of the vergence response to step changes in disparity was examined in two subjects as a function of the retinal locus and spatial frequency of fusion stimuli. Vergence velocity decreased for both subjects as retinal eccentricity increased and it was unaffected by spatial frequency. The same subjects had very different amounts of fixation disparity (FD). The flat forced duction FD curve for one subject who had rapid vergence adaptation remained unaffected by these two stimulus variables. In contrast, the steep forced duction FD curve for the other subject became steeper as retinal eccentricity and target coarseness increased. These results suggest that prism adaptation overshadows the effects of disparity vergence dynamics upon FD, but in the absence of adaptation, two dynamic properties of vergence (velocity and decay during occlusion) determine the slope of the peripheral limits of the forced duction FD curves. The results also suggest that the vergence system is more sensitive to small disparities subtended by high than low spatial frequency detail. We recommend that the slope of the extreme limits of the forced duction curve be used clinically to discriminate between normal and abnormal disparity vergence dynamics.

Adaptation, Ocular↗
PubMed1986

Combined effects of spatial frequency and retinal eccentricity upon fixation disparity.

The variations in fixation disparity (FD) with spatial frequency and retinal locus of fusion locks were examined in two groups of subjects having either steep or flat forced-duction FD curves. FD for subjects with flat curves was unaffected by either spatial frequency or diameter of fusion locks. FD of observers with steep forced-duction curves increased with both the coarseness and eccentricity of fusion locks. Panum's horizontal fusion range increased markedly with target spatial period but only modestly with retinal eccentricity. These results indicate that factors other than the dimensions of Panum's fusional area (PFA) result in the increase of FD found in some observers with peripheral fusion locks.

Convergence, Ocular↗