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M Whineray

Publications and source records attributed to M Whineray.

4 recordsLinked to original sources

Polycythaemia associated with a new haemoglobin variant: haemoglobin Palmerston North beta 23 (B5) val----phe.

A new haemoglobin variant, with increased oxygen affinity, has been identified in a patient with a long history of polycythaemia. This new haemoglobin, Hb Palmerston North, has an amino acid substitution of valine to phenylalanine at position beta 23 (B5). The increased oxygen affinity is accompanied by a decrease in globin stability which was responsible for the laboratory detection of the haemoglobinopathy.

Aged

Immune thrombocytopenia induced by cotrimoxazole.

Cotrimoxazole administration is occasionally associated with thrombocytopenia. Interference with folate metabolism has been postulated. The drug has also been postulated to induce an autoantibody by acting as a hapten, but proof has not been forthcoming. A case is reported in which the serum has been shown to contain an anti-platelet autoantibody requiring sulphamethoxazole or cotrimoxazole for activity.

Adult

Two years later ...

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