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Biomedical subjects

M Wierzbicka

Publications and source records attributed to M Wierzbicka.

At least 37 records · Page 2Linked to original sources
PubMed2000

[Neck metastases from unknown primary neoplasms (CUP syndrome)].

Carcinoma of unknown primary (CUP-syndrome) is taken into consideration when the patient has histologically confirmed metastases but the primary focus remains unknown or it's diagnosis is delayed. Metastases of unknown origin constitute from 5% to 31% of all neck metastases. Squamous cell carcinoma and anaplastic carcinoma metastases in the neck lymphatics suggest that location of primary focus can be found in head and neck region. Diagnostic procedures applied in detection of primary foci have been described. The knowledge of lymphatic metastases spreading routes is helpful in the primary focus detection. In the material of 1348 patients treated oncologically in the years 1991-1997 in ENT Department of Karol Marcinkowski University of Medical Sciences in Poznań, 22 were diagnosed for CUP syndrome. Primary foci were not found in 7 cases. In the remaining 15 patients the primary was located in nasopharynx, palatinal tonsil, tongue, hypopharynx, testes or breast. The treatment included the radical neck dissection with consecutive irradiation and/or chemotherapy, and in the case of diagnosing the primary one applied it's radical removal or radiotherapy.

Adult↗
PubMed2000

[Concentration of prothrombin fragments 1+2 (F1+2) and thrombin-antithrombin III complexes (TAT)in patients with primary non-small cell lung cancer, before and after resection].

The aim of our study was to detect the hypercoagulability in patients with lung cancer as well as to search for the marker indicating the effectiveness of tumour resection. Twenty four patients aged: 47-66 years were included into the study. The control group comprised 24 healthy human beings. The plasma concentrations of prothrombin 1 + 2 fragments (F1 + 2) and thrombinantithrombin III complexes (TAT) were measured before and 10 days after the tumour resection. It was shown, that F1 + 2 was a more sensitive hypercoagulability marker in patients with NSCLC, than TAT concentrations. Ten days after tumour resections, 78% of the patients have a normal level of TAT, while only 42% showed normalization of F1 + 2 concentrations. Our data indicate on coagulation activation in patients with different histological types of lung cancer. The risk of thromboembolic disorders still remains 10 days after tumour resection.

Adult↗
PubMed2000

[Ultrasonographic intraoperative evaluation of neoplastic changes in the tongue, tonsil, larynx, salivary and neck masses--preliminary report].

UNLABELLED: The new diagnostic method, intraoperative ultrasound is presented. There are very few publications in the literature, but they mainly concern the application of transcutaneous ultrasound in localizing the abscesses, their puncture and drainage. Intraoperative imaging of tongue, tonsil, larynx tumors, submandibular and parotid glands and neck masses have been provided by means of a linear 7.5 MHz probe in Poznań ENT Dept. K. Marcinkowski University of Medical Sciences. The application of this method is pioneer and new. The aim of the study was to compare the sensitivity and the specificity of preoperative, transcutaneous ultrasound with the intraoperative one, to assess how the new method influences the extensiveness of the performed procedures and sonographic-surgical correlation of safety margins. MATERIAL: 5 patients with parotid tumors, 4 with tongue, 6 with tonsil and 6 with larynx cancers have been examined. In 13 of them, apart from primary site diagnostics, the neck masses have been assessed. The imaging documentation is presented and the preliminary conclusions concerning the usefulness of this method have been drown.

Female↗
PubMed1999

The value of ultrasound examination in preoperative neck assessment and in early diagnosis of nodal recurrences in the follow-up of patients operated for laryngeal cancer.

The purpose of this study was to prove the superiority of ultrasound (US) examination of the neck in comparison to palpation, to reveal unpalpable nodes (pN0) before surgery, and to allow for the early detection of nodal recurrences in patients with laryngeal cancers. In all, 1,120 patients with laryngeal cancers were operated on between 1990 and 1997. All underwent palpation and neck US before surgery. In the pN0 group US revealed enlarged lymph nodes in 261/505 cases, of which 63 (24.14%) were confirmed as metastatic by histology. All 1,120 patients underwent regular postoperative US follow-up. Nearly 5,000 US examinations were performed; 136 patients who developed nodal recurrences had surgical salvage procedures. In this group 61 patients had small, nonpalpable lesions, and 46 patients discrete and slight changes in scarred necks. In this latter group of 117 patients with nonpalpable lesions, 105 cases were histologically confirmed as metastatic. In postoperative check-ups, metastases were suspected in sonographically detected subclinical nodes, but the US scans obtained were difficult to interpret. In these cases, because of the dynamics of lesion changes, US was repeated two to three times at 10- to 14-day intervals. This reappraisal enabled us to exclude malignancy in regressing nodes, as well as to obtain the stable picture of scar, and support a diagnosis while the lesion grew larger or a central area of low attenuation or hypoechogenic echos appeared in the nodal capsule. Successful radical reoperation for tumor was done on110 patients; 78 patients underwent successful salvage surgery after an early US diagnosis. The sonographic-surgical correlation was nearly 95% and the sonographic-histological correlation was 90%. The follow-up period was 1-49 months. In all preoperative assessments US was found to be a valuable tool in the staging of laryngeal cancer and planning the extent of surgery. Close follow-up with US after radiotherapy and initial operation was essential for the early detection of tumor recurrences, making surgical salvage still feasible.

Follow-Up Studies↗
PubMed1999

Localization of lead in Allium cepa L. cells by electron microscopy.

The study of mechanisms by which plants tolerate lead requires ultrastructural observations of lead distribution in cells. However, the conventional technique used in electron microscopy brings up the problem of lead translocation from tissues during chemical processing. If most of the lead is washed out of tissues, then the method is not suitable for this type of study; if, however, it remains in the tissues, the method can be used. The amount of lead washed out of Allium cepa root tips during successive stages of fixing and dehydrating was determined in this study. Allium cepa plants were treated with Pb(NO3)2 in hydroponic cultures. The conventional fixing (GA, OsO4) and dehydration (alcohol + propylene oxide or acetone) methods used in the preparation of tissues for electron microscopy were then applied to root tips. The lead content in tissues and in reagents was analysed in the successive stages of the procedure. It was shown that 96.2% of the lead taken up was retained in the tissues and was not washed out during fixing and dehydrating. Of the 3.8% of the lead lost in the chemical procedure, about half was washed out during fixing in osmium tetroxide. This reagent is thus the least suitable for this type of study. Our study showed that the conventional electron microscopy preparative technique is appropriate for studying the distribution of lead deposits in A. cepa root cells, owing to the way in which lead is compartmentalized/sequestered in plant cells.

Allium↗
PubMed1999

[Foreign bodies in the esophagus].

1496 patients with foreign bodies of esophagus, reported between 1945-1997 to ENT Department of K. Marcinkowski University of Medical Sciences, were analysed. The age ranged from 0.5 to 95 years, but the most numerous group was under 5 years of age. Men outnumber women. Very detailed anamnesis, oropharynx and hypopharynx examination, neck palpation, chest X-ray were crucial for diagnosis. More than 50% of patients reported within first 10 hours after foreign body wedged. The most often met foreign bodies were: bones, coins, denture, fish bones, fruit-stones, buttons. The most dangerous were supposed to be: needles, pieces of glass, springing anchores, safety razors. Foreign bodies were removed by means of rigid esophagoscopes. In 75.3% foreign bodies occupied the first isthmus. Serious complications met in the analysed material, included: esophageal wall perforation [27], mediastinitis [21], aortal hemorrhage [3], esophagus-tracheal fistula [1]. Intramural abscesses, posteriol pharyngeal wall abscesses were found more often. 98% of esophageal foreign bodies were removed by the same route they had been introduced.

Adolescent↗
PubMed1999

[Neck reoperations in patients with laryngeal, lingual and tonsillar neoplasms].

One of the most common reasons of failure in head and neck cancer treatment are metastases in regional lymph nodes. Preoperative assessment of the neck lymphatic system is an important task, but even more crucial goal is to monitor the patients after initial operation or combined treatment. The frequency of nodal recurrences ranged from 9% to 23%. It constitute nearly 50% of all treatment failures in larynx, tongue and tonsil malignancies. There are different methods of therapy in nodal recurrence treatment, but the most recommended, easily accessible and widely used is surgery. The group of 2134 patients (1580--larynx cancer, 286--tongue and floor of mouth cancer, 268--tonsil cancer) treated between 1987-1997 were operated in ENT Dept. of K. Marcinkowski University of Medical Sciences in Poznań. In 269 patients were detected the nodal recurrence. In 149 cases the recurrence was homolateral, in 48 heterolateral, in 71 patients the neck was not previously treated. 152 patients were irradiated on the neck fields just after primary surgery. The rate of recurrences was 12.6%. Authors analysed and compared the percentage of recurrences for different primary lesions: larynx, tongue and tonsil neoplasms. The period of time from the last control examination to the moment of recurrence detection, its frequency on particular nodal levels, number of recurrences and trends between years 1992-1997 were assessed. 208 patients who developed nodal recurrence had surgical salvage, 59 patients were not qualified to surgery because of the lesion extension. Neck re-operations were divided into 3 main types: selective, modified radical and radical neck dissection. The frequency of particular neck dissection types, curative rates and difficulties of performing the salvage surgery were discussed.

Catchment Area, Health↗
PubMed1999

[Otitis media with effusion].

The authors present monographic data as regards causes, epidemiology, patomechanism and treatment of otitis media with effusion. The attention is paid to connections between this pathology and acute, recurrent otitis media and chronic eustachian tube insufficiency. The authors underline occult onset, asymptomatic and chronic character of this disease, irreversible consequences and hearing impairment. Among treatment methods the most effective seemed to be the surgery one: adenotomy with simultaneous tympanostomy. The authors give the schedule of management of otitis media with effusion and indications to ventilation tube insertion.

Acute Disease↗
PubMed1999

[Pleomorphic adenoma of rare localization in the nose].

Pleomorphic adenoma localised in nasal cavity is extremely rare. Authors described a case of mixed salivary gland tumor in the lateral wall of nasal cavity. We are presented, on the base of our experience and literature data, pathogenesis, clinical course and treatment of this tumors situated in atypical places.

Adenoma, Pleomorphic↗
PubMed1999

[Amyloidosis of the larynx].

The paper presents three cases of localised amyloidosis of the larynx. The study was focused on case histories, findings of larynx examination and method of treatment was discussed. Amyloidosis is a disease characterised by gathering of amyloid deposits in extracellular space. The amyloid fibres consist of different kinds of proteins which have the ability of forming laminae. This disease may be secondary to numerous general processes in which amyloid proteins forms. Etiopathogenesis of this disease has not been explained yet. In the following paper the latest theories and classification of amyloidosis are presented.

Adult↗
PubMed1999

[Sarcoidosis presenting as isolated nodules of the parotid and submandibular glands].

The authors documented the case of healthy, 50 year old women with a sarcoid lesions of the parotid and submandibular gland without any other manifestations of the disease. The presence of noncaseating granulomas in salivary tissue is a specific feature of sarcoidosis. Primary involvement of the intraglandular lymph nodes with a secondary involvement of the salivary gland parenchyma was detected. Etiopathogenesis, diagnostics and clinical features of sarcoidosis were presented.

Diagnosis, Differential↗
PubMed1998

T-cell interactions with extracellular matrix proteins in periodontal disease.

Lymphoid cell infiltration of periodontal tissues undergoing pathological destruction suggests a functional interdependence between connective tissue proteins such as collagen, fibronectin and elastin and mononuclear cells, mainly T lymphocytes. The aim of the study was to assess T lymphocyte proliferation after stimulation by mAb OKT3 and then costimulation by ECM (extracellular matrix) proteins, as well as T-cell adhesion to connective tissue proteins in patients with adult periodontitis, early-onset periodontitis, chronic gingivitis and experimental gingivitis. Controls included patients with clinically healthy periodontium. Statistical analysis of results showed a significantly decreased level of T lymphocyte proliferation in response to costimulating action of ECM proteins among patients with adult periodontitis as compared to the control group. Reactivity of T-cells was much higher in experimental gingivitis than in adult periodontitis, and significantly lower in chronic gingivitis than in controls. In addition, T-cell interaction with ECM proteins was abnormal in early-onset periodontitis patients, but was not statistically significant.

Adult↗
PubMed1998

[Foreign bodies in the lower respiratory tract: experience based on materials gathered in the ENT department of the Poznań Higher School of Medical Sciences between 1945 and 1997].

258 foreign bodies were removed from the lower respiratory tract in ENT Department of Poznań High School of Medical Sciences between 1945 and 1997. The age ranged from 0 to 85 years, but the most numerous group (68%) was found between 0 and 10 years. 86.5% patients were admitted to hospital during first three days after inserting the foreign body. The longest time of foreign body existence inside the bronchus was a period of 18 years. The most often met foreign bodies were: bones, bean seeds, fruit stones, pieces of food, iron nails. Spontaneous evacuation of the foreign body took place in 4% of cases. 98% of foreign bodies were removed by means of rigid bronchoscopy. Bronchofiberoscopy was performed for diagnostic purposes or for taking out foreign bodies located in the peripheral parts of the bronchial tree. 3% of patients were referred to the further toracosurgery treatment.

Adolescent↗
PubMed1998

[Sarcoma neurogenes of the larynx].

Malignant nonepithelial neoplasms of the larynx are rare, and tumors of mesenchymal origin constitute 4-6% of all malignant neoplasms of the larynx. Sarcoma neurogenes vel malignant schwannoma make up 10% of all soft tissue sarcomas. In this paper a case of the extremely rare malignant schwannoma of the larynx is presented. In world literature we have met four case reports describing tumors of this histological morphology and location.

Aged↗
PubMed1998

[The value of ultrasound examination for assessing the lymph nodes of the neck in the follow-up of patients surgically treated for laryngeal cancer].

The purpose of this study was to demonstrate the superiority of ultrasound examination of the neck in comparison with palpation in patients operated on and irradiated because of the larynx cancer. Recurrence is common after laryngectomy, especially for advanced laryngeal cancer. Close ultrasound follow-up of patients after initial operation is essential to detect recurrence early, while surgical salvage is still feasible. Ultrasound also proved to help in the follow-up and control during radiation therapy. In this special group of patients nodal recurrence is more difficult to detect early by clinical examination because of scars and oedema due to prior surgery and radiotherapy. A group of 810 patients operated on between 1990 and 1995 was followed up by means of ultrasound. 3100 US examinations were performed in this group. 102 patients who developed nodal recurrence had surgical salvage. The follow-up of these patients lasted for 1-49 months. A comparison between patients with palpable lesions and lesions detected sonographically was performed regarding: size of the nodes, pattern of recurrence, possibility of performing radical surgery, time from the last control examination. Apart from demonstrating non-palpable nodes US may also depict the size, multiplicity, relation to the surrounding vessels and invasion of the carotid artery, as well as malignant extension in the salivary glands or thyroid.

Follow-Up Studies↗
PubMed1998

[Neurofibroma of the parapharyngeal space: a case report].

Neurofibroma is rarely found arising in the head and neck region. Parapharyngeal space neurofibroma is one of the rare complications of neurofibromatosis type I, occurring in less than 5% of all parapharyngeal space neoplasms. Solitary neurofibroma type II in this location has not been reported so far in literature. In this paper we describe a case of a huge neurofibroma of parapharyngeal space, indicating the main diagnostic procedures (especially CT scan), and report the surgical treatment.

Female↗