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Biomedical subjects

M Wilczak

Publications and source records attributed to M Wilczak.

At least 19 recordsLinked to original sources
PubMed2006

Efficacy of 12 weeks supplementation of a botanical extract-based weight loss formula on body weight, body composition and blood chemistry in healthy, overweight subjects--a randomised double-blind placebo-controlled clinical trial.

OBJECTIVE: The aim of this study was to evaluate the efficacy and safety of composite extracts in reducing weight, as the main outcome measure. Secondary measures of the study were body composition change. DESIGN: Randomised, double blind, placebo-controlled clinical trial. SETTING: Tertiary university clinic. SUBJECTS: hundred and five subjects, 5 of them withdrawn consent, 2 drop-outs not related to study preparation. INTERVENTION: two tablet per meal concept supposed to generate a "psychological" therapy-like approach during 12 weeks supported by measured physical activity. The tablets 1 (one hour before meals, comprises extracts of Asparagus, Green tea, Black tea, Guarana, Mate and Kidney beans) and 2 (taken half an hour after meals, comprises extracts of Kidney bean pods, Garcinia cambogia, and Chromium yeast) are taken twice daily with two main meals. RESULTS: A significant change of the Body Composition Improvement Index (BCI) was observed in the active extract group compared to placebo (p = 0.012). Weight, BMI, waist-to-hip ratio was not statistically different between groups. Body fat loss was greater in active group (p = 0.011) compared to placebo. A weight loss parameter corrected for exercise was introduced and found to be higher in active group (p = 0.046) than in placebo, meaning that the formula was more efficacious, due to a concurrently performed exercise program--a recommended strategy for life style modification. CONCLUSIONS: A significant change of the Body Composition Improvement Index and the decrease in body fat was statistically significant in active extract subjects compared to placebo. A change in some outcome measures like: weight, BMI failed to produce significant difference between groups.

Adult↗
PubMed2005

Serum tumor necrosis factor alpha receptors p55/p75 ratio and ovarian cancer detection.

OBJECTIVE: Early ovarian cancer detection is still very difficult and patients are mostly in advanced stages, with obvious influence on poor prognosis. METHOD: Fifty-one ovarian cancer patients and 16 healthy controls had the serum concentrations of TNF alpha receptor p55, p75 and CA-125 measured prospectively and preoperatively. RESULT: Mean concentrations of TNF alpha receptor p55, p75 and CA-125 in patients with ovarian cancer were higher than in controls. The ratios of p55 and p75 receptor in ovarian cancer and controls were 0.73+/-0.38 and 0.55+/-0.06 respectively. The areas under ROC curve in detecting malignancy (all FIGO stages) were 0.73, 0.65, 0.88 and 0.85 for p55, p75, p55/p75 ratio and CA-125 respectively. The areas under ROC curve in detecting stage I of ovarian cancer were 0.52, 0.60, 0.84 and 0.66 for p55, p75, p55/p75 ratio and CA-125 respectively. CONCLUSION: Serum TNF alpha p55/p75 ratio showed promising value in ovarian cancer detection.

CA-125 Antigen↗
PubMed2005

Evaluation of soluble tumour necrosis factor alpha receptors p55 and p75 in ovarian cancer patients.

PURPOSE: Evaluation of serum TNFalpha receptor 1 (p55) and 2 (p75) concentrations preoperatively in patients with ovarian masses. METHODS: Estimation by ELISA assay in 51 women with ovarian cancer and 16 healthy controls. Mean values and correlations with CA-125, tumour volume index, morphological score, pathological finding and cytoreduction were estimated. RESULTS: Mean concentrations of p55 and p75 in cancer patients were 2006 +/- 1030 pg/ml and 2849 +/- 1092 pg/ml, respectively, whereby for controls 1323 +/- 291 pg/ml and 2386 +/- 475 pg/ml, respectively. The area under the ROC curve for CA-125, p55 and p75 for cancer (FIGO Stages I-IV) were: 0.85 (95% CI 0.75-0.92), 0.73 (95% CI 0.60-0.83) and 0.65 (95% CI 0.50-0.77), respectively. Serum p55 correlated with morphological ultrasound score and CA-125 but not with FIGO stage, tumour grade or tumour volume index. No correlations of p75 with these parameters were observed. CONCLUSION: Estimation of p55 and p75 provide little information in ovarian cancer patients and have poor detecting power.

Adult↗
PubMed2001

[Coexistence of female sexual organ malformation and urinary tract anomalies].

OBJECTIVES: The aim of the study was to estimate the correlation between sexual organs and urinary tract malformation. MATERIALS AND METHODS: The retrospective analysis of clinical data obtained from 50 patients with sexual organs anomalies diagnosed in the Academic Gynaecological Centre between 1992-1999 was performed. RESULTS: Material included 24 patients with the Meyer-Rokitansky-Küster-Hauser syndrome and 26 with other sexual organs' malformations. Frequency of urinary tract anomalies was 42%, 11 patients with Meyer-Rokitansky-Küster-Hauser syndrome and 11 with other malformations. The gravity of urinary tract anomalies showed no statistical significant difference dependent on the type and symmetry of genital malformation. Urinary tract anomalies were more frequent in cases of asymmetric genital malformation and the difference was statistically significant. CONCLUSIONS: Intravenous urography proofed to be more sensitive than ultrasonography in diagnosing urinary tract anomalies.

Abnormalities, Multiple↗
PubMed2001

[Comparison of the frequency of selected gynecologic operations conducted as laparotomy and laparoscopy during 1993-1997].

UNLABELLED: The aim of the study was to compare frequency of four gynecological operations: myomectomy, tubal surgery, cystectomy and operative management of ectopic pregnancy, performed by laparotomy or laparoscopy, by the same team of surgeons. In the years 1994-1997 in Division of Reproduction Poznań University Medical School 647 cystectomies, 208 myomectomies, 68 tuboplasties and 50 surgical treatments of ectopic pregnancy were done. Among 973 operations--684 (70.3%) were performed by laparoscopy. There was a gradual tendency in increasing endoscopic procedures. Comparing the year 1994 and 1997 percentage of operations performed by laparoscopy significantly changed: In tuboplasty from 83% to 95%, cystectomy from 35.9% to 80.3%, ectopic pregnancy from 61.5% to 91.7% and myomectomy from 52.7% to 61.5%. Patient hospital stay decreased significantly after laparoscopic procedures (from 5.1 days to 3.25 days). During the study period open surgery followed laparoscopy only in 8 cases (1.1%) because of complications or technical difficulties. CONCLUSION: 1. Operative laparoscopy is a safe and effective procedure, in many cases replacing open surgery. 2. Shortening of hospital stay and recovery period after laparoscopy is one of the main advantages of this method of treatment.

Academic Medical Centers↗
PubMed2001

[Gynecologic endoscopy in the greater region of Poland during 1988-1998].

The aim of the study was to analyze the state and development of the gynaecological endoscopy in the Wielkopolska region in years 1988-1998. The questionnaire included gynaecological and obstetrical departments of 31 hospitals: 1 academic center, 5 former regional hospitals and 25 small hospitals. At the end of 1998 35.5% of departments were equipped with laparoscopes and 9.7% with histeroscopes. There was an increase in the laparoscopic procedures from 151 to 832 estimated in these years, as well as from 181 to 314 hysteroscopies. The detailed analysis of procedures and dynamic of its increase according to the type of hospital is presented. The experience of the staff was also analyzed. We demonstrated the insufficient equipment in the region, in spite of the right tendencies in the spectrum of the endoscopic procedures and the experience of the physicians who perform laparoscopy and hysteroscopy.

Adult↗
PubMed2001

[Pathologies observed in barium enema examination in patients with gynecological disorders].

The aim of our study was to analyse retrospectively 171 patients with gynaecological diseases, who have undergone barium enema examination in Third Teaching Hospital in Poznań between 1992 and 1998. 79 patients were diagnosed with ovarian tumours, in 24 cases their colon was dislocated. Stenosis was detected in 20 women and in five situations inflammatory changes of the colon were present. Malignant infiltration of large intestine was suspected in ten patients. The second group included 24 women diagnosed with tubo-ovarian abscesses and adnexitis. Three of them had dislocated colons. Stenosis of large bowel was detected in 11 patients and inflammatory changes in 8. In the next group of 35 patients' myoma uteri, myometrial endometriosis and carcinoma of colli uteri were detected. Barium enema examination revealed that 10 women had dislocated colons. In the third group stenosis was detected in eight cases, two patients had radiological signs of cancer infiltration and twice inflammatory changes of the large bowel were present. Frequency of radiological changes in barium enema examination was evaluated in the aforementioned groups. Results were compared with group of 33 patients treated for endocrinological disorders, sterility and minor pelvis pain syndrome. Frequency of dislocation of colon was compared with size of changes of ovaries measured during ultrasound examination. Our results showed that barium enema is still an important supplementary examination, which can give a great deal of beneficial information concerning the clinical condition of the patient. This procedure is useful before surgical intervention especially in cases of suspected ovarian cancer. We must underline that the same or similar information can be obtained using other methods without such radiation exposure.

Adult↗
PubMed2001

[Evaluation of professional Internet resources' use by gynaecologists and obstetricians].

OBJECTIVES: The aim of this study was to evaluate the use of internet as the additional education tool by gynaecologists and obstetricians. MATERIAL AND METHOD: Prospective questionnaire was sent December 1999 to gynaecological departments of 35 hospitals in Wielkopolska region. Data were collected in MS Access data base until February 25, 2000. Analysis was performed using MS Excel packet. RESULTS: Questionnaires returned from 25 hospitals (71.4%) filled by 193 physicians. About 52.8% of them use the internet for searching professional information. Among internet users 77.4% search Medline data bases, 22.5% use discussion lists, 64.7% search for education possibilities, 67.6% are interested in precise professional topics, 31.4% read the OnLine papers and casuistic, 1.0% has the own www page. The importance of internet was stressed by 84.3% of internet users. Young physicians and those in specialising training are frequent users of internet. CONCLUSION: The access to internet is not satisfactory, but the physicians use all possible internet options.

Female↗
PubMed2001

[Changes in mammography and breast ultrasonography in women undergoing hormonal replacement therapy].

OBJECTIVES: The aim of this study was to compare changes in mammography and breast ultrasonography in women undergoing Hormonal Replacement Therapy (HRT) and a control group. MATERIALS AND METHODS: Retrospective analysis of clinical documentation form 12.1998 to 11.1999 of 1075 women over 45 years old. COLLECTED DATA INCLUDED: Breast imaging, hormonal therapy, gynecological, obstetrical and oncological interview and examination. Analysis was performed using MS Access DataBase and Statistica v5.0, p = 0.05 was considered significant. RESULTS: 710 women were actually undergoing HRT and 365 were qualified to the control group. Oral HRT was used by 72.2% women, transcutaneous by 24.1% and transvaginal by 3.7%. There were no differences of breast cancer risk factors, age and cancer suspicious changes (relative risk 1.03) in analyzed groups. Suspicious microcalcifications were rarer in women undergoing HRT (relative risk 0.49) while breast cysts (especially to 0.5 cm) were more frequent. There were no statistically significant differences in other changes like: benign breast masses, macrocalcifications and mastopathy. All findings referred to superiolateral quadrant in 50% of HRT women and 56% of control group. CONCLUSIONS: Hormonal Replacement Therapy has no marked influence on changes in mammography and ultrasonography. Among women undergoing HRT, microcysts are more frequent while suspicious microcalcifications are less.

Breast↗
PubMed2000

[Laparoscopic myomectomy].

OBJECTIVES: The aim of our study was clinical analysis of the factors influencing on laparoscopic myomectomy. STUDY DESIGN: Retrospective analysis of the operative protocols. MATERIAL AND METHODS: Two hundred nineteen women had laparoscopy because of unexplained infertility (n = 109) unexplained infertility and myomas (n = 41), myomas (n = 36), endometriosis suspicion (n = 20) ovarian cyst (n = 9) or pelvic pain syndrome (n = 4). RESULTS: Among 299 myomas 186 were extirpated during laparoscopy. In 39 cases suturing of the myometrium was necessary. Electrocautery was performed in 27 cases and laser-vaporisation in 8. In 28 women the operation was postponed because of small myomas and mainly poor operative technique (beginning of the learning curve). In two of them second laparoscopy was performed after GnRH therapy. An analysis of the factors which enable laparoscopic myomectomy was performed. The most important factors are: size and number of the myomas, localization in the myometrium, experienced hands and operative room equipment. CONCLUSIONS: Uterine myomas are one of the indications to operative laparoscopy. Meticulous analysis of the operative conditions as well as the assessment of the team experience should always precede laparoscopy.

Adult↗
PubMed1995

[Treatment of condylomata acuminata of the male reproductive organs with CO2 laser under colposcopic control].

The first results of laser therapy in treatment of condylomata acuminata of male reproductive organs are reported. Between November 1991 and December 1993 in Department of Reproduction, Institute of Gynecology and Obstetrics, Karol Marcinkowski University School of Medical Sciences, Poznań in nine patients with condylomatous changes of reproductive organs CO2-laser therapy under colposcopic control was done. In 7 of them the healing was achieved. In two patients second laser therapy was done. All patients are still under control in Department of Reproduction and there was no recurrence diagnosed.

Adult↗
PubMed1995

[Point CO2 laser vaporization in treatment of superficial endometriosis of the uterine cervix].

The study showed the treatment of superficial endometriosis of the uterine cervix in 54 women between November 1991 and January 1994. After first vaporisation 43 patients were cured successfully. In 8 cases vaporisation should be repeated and in 3 women the operation should be performed for the third time. All patients are still under control in our department and there is no recurrence observed.

Adult↗
PubMed1995

[Use of CO2 laser in the treatment of condylomata acuminata of the anogenital region in pregnant women].

The first results of treatment of condylomata acuminata of anogenital region in 11 pregnant women were presented. The analysis were made in Department of Reproduction, Institute of Gynecology and Obstetrics, Academy of Medicine, Poznań. All patients were treated between 28 and 35 week of pregnancy. After first laser-therapy the healing achieved in 9 women. The second lasertherapy was required in 2 patients. It was done after 3 weeks. Complete destruction of pathological changes was obtained. All women had vaginal delivery and no complications (connected with HPV infection) in their newborns were found. The authors said that CO2-lasertherapy under colposcopic control is a reliable method for treatment of condylomata acuminata in pregnant women.

Adolescent↗
PubMed1994

[Hysteroscopy in the diagnosis and treatment of residua after evacuation of hydatidiform mole].

The authors showed the case of 23 years old multipara treated in Department of Reproduction, Institute of Gynecology and Obstetrics, Academy of Medicine, Poznań because of hydatidiform mole using the exhaustion of uteri. After 8 weeks the hysteroscopy was done in order to explain the reasons of elevated serum beta hCG levels. During the hysteroscopy the polypoid lesion was recognized and removed using the electric resectoscope. After this endoscopic operation the normalization of serum beta hCG levels was achieved.

Adult↗
PubMed1994

[Erosion of the uterine cervix in women with primary infertility treated with CO2 laser].

The authors described the results of treatment of erosions of the uterine cervix in 78 women with primary sterility with CO2-laser vaporisation in Department of Reproduction, Institute of Gynecology and Obstetrics, Academy of Medicine, Poznań. The results were estimated through clinical, cytological and colposcopical examinations in the term of 6 weeks and 3 months after therapy. The Insler's cervical mucus test was done in all women after 3 months. In all women the healing was achieved and five of them were needed for second laser therapy because of superficial endometriosis. The authors think that CO2-laser vaporisation (under colposcopical control) of erosions of the uterine cervix in women with primary sterility is the reliable method. The wound's healing after laser therapy is quick and without any complications. Laser therapy causes no trauma of the cervix structure and does not disturb in excretion of mucus by cervical glands.

Adult↗
PubMed1994

[CO2 laser in treatment of uterine cervix dysplasia in women with infertility].

The authors presented use of carbon dioxide laser in treatment of dysplasia of the uterine cervix in women with malreproduction. Between November 1991 and September 1993 in the Department of Reproduction, Institute of Gynecology and Obstetrics, Academy of Medicine, Poznań the CO2-laser vaporisation in 21 women was done. In 19 patients the healing was achieved. In two of 21 women in control examination CIN was diagnosed. They were treated with electroconisation. In control examination no signs of dysplasia in all women were observed. The patients are still under control in our department.

Adult↗