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Biomedical subjects

M Wingfield

Publications and source records attributed to M Wingfield.

23 records · Page 2Linked to original sources
PubMed1975

Elimination of antipyrine from saliva as a measure of metabolism in man.

The salivary half-life of antipyrine was used as a convenient procedure for estimating the relative rates of drug metabolism in man. The concentration ratio of antipyrine in plasma and saliva was one over a 24-hr period following the oral or parenteral administration of the drug to man and rat. Phenobarbital, a known stimulator of drug metabolism in animals and man, increased markedly the elimination of antipyrine from saliva of rats, while SKF-525A, a potent inhibitor of drug metabolism, prolonged the elimination of antipyrine from rat saliva. In addition, the known sex difference in the metabolism of drugs in the rat was detected by measuring the elimination rate of antipyrine from saliva of male and female rats. The clinical application of the procedure indicated that a group of epileptic patients treated with anticonvulsants for more than 2 mo had a mean antipyrine salivary half-life of 4 hr, whereas a mean half-life of 13 hr was found in a group of normal volunteers. The results show that the elimination rate of antipyrine from saliva is a useful index of drug metabolism in animals and man.

Adolescent↗
PubMedDate not supplied

Angiogenesis: a new theory for endometriosis.

Excessive endometrial angiogenesis is proposed as an important mechanism in the pathogenesis of endometriosis. Evidence is reviewed for the hypothesis that the endometrium of women with endometriosis has an increased capacity to proliferate, implant and grow in the peritoneal cavity. Data is summarized indicating that the endometrium of patients with endometriosis shows enhanced endothelial cell proliferation. Results are also reviewed indicating that the cell adhesion molecule integrin alphavbeta3 is expressed in more blood vessels in the endometrium of women with endometriosis when compared with normal women. Taken together, these results provide evidence for increased endometrial angiogenesis in women with endometriosis when compared with normal subjects. Endometriosis is one of the family of angiogenic diseases. Other angiogenic diseases include solid tumours, rheumatoid arthritis, psoriasis and diabetic retanopathy. Excessive endometrial angiogenesis suggests novel new medical treatments for endometriosis aimed at the inhibition of angiogenesis.

Cell Division↗
PubMedDate not supplied

Laparoscopic management of tubal ectopic pregnancies--the Irish experience.

Ectopic pregnancies are being dealt with increasingly via the laparoscope on account of several advantages over conventional surgery. We commenced a Laparoscopic Ectopic service at the National Maternity Hospital in November 1995. This paper reviews the first 8 months of the service and is the first series of its kind in Ireland. All confirmed Ectopic pregnancies (EPs) between November 1995 and June 1996 are included in the study. Demographic details, diagnosis, operative details, analgesic requirements and outcome are reviewed. There were 56 tubal EPs giving an incidence of 1 per 81 live births. 35 were managed laparoscopically and were noted to have lower morbidity, analgesic requirement, reduced convalescence, shorter inpatient stay and thus lower cost. We have shown that EPs can be managed successfully via minimal access surgery in an Irish setting. In fact 22 of the last 24 cases of EPs were managed via the laparoscope.

Female↗