Biomedical subjects

M Wolenski

Publications and source records attributed to M Wolenski.

4 recordsLinked to original sources

PubMed2003

Enhanced activation of CD83-positive T cells.

CD83 is a marker molecule for mature dendritic cells (DCs) but is also substantially expressed on activated T cells in humans and mice. Its function is unknown, but CD83 knockout mice show an impaired thymic maturation of CD4-positive cells and soluble CD83 inhibits partially antigen-specific responses in vitro pointing to a role of CD83 in the immune system. Here we show that CD83-positive T cells produce strongly increased amounts of interferon-gamma and interleukin-2. In contrast, constitutive expression of CD83 on DCs alters neither the activation of DCs following addition of lipopolysaccharide nor the ability to present antigenic peptides. Thus, the expression of CD83 on T cells has direct functional consequences for tuning the activation threshold.

Animals↗

PubMed1991

The single puncture approach for advanced pelviscopy surgery.

1. The single puncture laparoscopy technique uses the umbilicus as the sole puncture site for the performance of surgical procedures. 2. The single puncture technique is simple, reduces complications, allows for faster recuperation and decreased operating time, is more cost-effective, and offers improved cosmetic results. 3. Each member of the surgical team must have all of the knowledge and skill related to each respective role. Major complications can only be avoided by being especially attentive to detail.

Female↗

PubMed1991

Laparoscopic hysterectomy.

1. Laparoscopic hysterectomy obviates the need to create a traditional large abdominal incision. Through the laparoscope, surgical steps similar to those of a traditional abdominal hysterectomy are done prior to removal of the uterus via the vagina. 2. The dramatic improvement in postoperative recuperation in laparoscopic hysterectomy is the result of several factors: avoidance of laparotomy incision; minimal degree of traumatized and devitalized tissue as finer instrumentation is used; minimal use of suture material, reducing the chance of tissue reaction; and avoidance of postoperative bowel function compromise. 3. In the long run, laparoscopic hysterectomy will not replace all traditional abdominal and vaginal hysterectomies. Not all hysterectomies are candidates for laparoscopic surgery, such as patients with large pelvic masses or marked distortion of the anatomy due to various disease processes (ie, cancer).

Female↗

PubMed1991

Laparoscopic appendectomy incidental to gynecologic procedures.

1. The advantages of laparoscopic appendectomy over the traditional "open" method include decreased chance of wound infection, early ambulation and resumption of normal daily activities, decreased postoperative pain, improved diagnostic accuracy, better visualization of intra-abdominal anatomy, improved cosmetic results, and avoidance of "open" appendectomy if pathology is found during routine gynecologic laparoscopic surgery. 2. Single-puncture laparoscopy has several advantages over the multiple-puncture approach, including simplicity, expediency, lower cost, avoidance of potential complications associated with multiple punctures, improved cosmetic results, and flexibility to be converted into multiple-puncture laparoscopy or laparotomy when indicated. 3. Laparoscopy is expected to eventually replace laparotomy as the primary approach for most cases of diseases of the appendix. It is not suitable in cases of dense adhesions with distorted anatomy, malignancy, or severe pelvic peritonitis.

Appendectomy↗