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Biomedical subjects

M Wulff

Publications and source records attributed to M Wulff.

34 records · Page 2Linked to original sources
PubMed1996

The structure of the Escherichia coli EF-Tu.EF-Ts complex at 2.5 A resolution.

The crystal structure of the EF-Tu.EF-Ts complex from Escherichia coli has been determined to a resolution of 2.5 A. The complex contains two subunits of each of the elongation factors. The two EF-Ts molecules form a tight dimer, but there is little contact between the two EF-Tu molecules. The interaction of EF-Ts with EF-Tu results principally in the disruption of the Mg2+ ion binding site, thereby reducing the affinity of EF-Tu for guanine nucleotides.

Amino Acid Sequence↗
PubMed1996

Congenital malformations in the vicinity of a smelter in Northern Sweden, 1973-1990.

The objective was to evaluate the rates of congenital malformation in children born in a population living around a smelter and to employees at the smelter, in a community in northern Sweden. By means of record linkage of the birth register and various registers of congenital malformations, a retrospective study of a birth cohort according to place of parental residence and employment was carried out to assess rates of congenital malformation occurring between 1973-1990. Neither a general, nor specific, significantly increased risk of congenital malformation was seen in the 2724 children born to women living close to the smelter or to employees of the smelter compared with the 15191 children in the reference population. No increased risk could be ascertained although there are reservations concerning the small sample size of the study group.

Case-Control Studies↗
PubMed1996

Cancer incidence for children born in a smelting community.

The Rönnskär smelter in Skellefteå, Sweden, produces significant environmental pollutants, such as lead, arsenic, copper, cadmium and sulphur dioxide. The purpose of the present study was to determine whether children born to women living near the smelter during pregnancy had an increased risk of childhood cancer. The study group consisted of children born between 1961 and 1990 in the municipality of Skellefteå and parish of Holmsund. Through linkage to the Swedish Cancer Registry cancer diagnoses in the study group were obtained and compared with the expected ones based on the national incidence rates. Thirteen cases of childhood cancer were identified among children born in the vicinity of the smelter against 6.7 expected (SIR 195, 95%CI 88-300). Among distant born the observed number of cases (n = 42) was similar to that expected (n = 41.8).

Adolescent↗
PubMed1995

Perinatal outcome among the offspring of employees and people living around a Swedish smelter.

OBJECTIVE: The purpose of this study was to determine if emissions from a smelter affect the birthweight of offspring and increase the risk of prenatal death. METHODS: A historical cohort was formed from registers of birth and employees from 1961 to 1991. Comparisons of birthweight and perinatal deaths between children born to smelter employees or children born to women living around the smelter and those of a reference population were performed. To study reproductive effects before 1961, a case-referent study was performed with cases of stillbirths from 1937-1961 in one parish. RESULTS: No differences in birthweight were found between the children born to employees or to people living near the smelter and those in the reference group. An increased risk of perinatal death among children born to women in the exposed group was seen during the period 1966-1970. However, for the rest of the observation period, 1961-1990, this higher risk was not apparent. CONCLUSIONS: For the last 20 years emissions from the smelter had not affected the birthweight and the risk of perinatal death among the offspring of parents living near the smelter or those employed at the smelter.

Birth Weight↗
PubMed1978

A prospective comparative study of clinical and pathological characteristics in Icelandic and Danish patients with gastric ulcer, duodenal ulcer, and X-ray negative dyspepsia. II. Histological results.

The occurrence of gastritis in antral and body mucosa is compared in an Icelandic and a Danish group of patients with gastric ulcer, duodenal ulcer, and X-ray negative dyspepsia. In all 93 Icelandic and 88 Danish patients were examined. All signs of antral gastritis were more frequent in Icelandic than in Danish patients, but only the incidence of superficial inflammation and decreased mucus content in surface and crypt epithelium differed significantly. In body mucosa pseudopyloric metaplasia was more frequent in Iceland and occurred equally freqeuntly in all three diseases. A statistically significant correlation was found between macroscopic gastritis and occurrence of antral superficial inflammation and between smoking and superficial inflammation and decreased mucus content in the pyloric biopsy specimen. The presence of histological gastritis was not correlated to the intake of alcohol and salicylic acid, nor to the presence of pain at the time of investigation.

Adult↗
PubMed1977

A prospective comparative study of clinical and histological characteristics in Icelandic and Danish patients with gastric ulcer, duodenal ulcer, and X-ray negative dyspepsia. I. Design and clinical features.

Iceland (IS) and Denmark (DK) are ethnically, culturally, and economically closely related Nordic countries, but gastric cancer is much more frequent in Iceland, and other differences in the occurrence rates of gastric diseases are also suspected. Therefore a cooperative study was initiated comparing Icelandic and Danish patients with gastric ulcer (GU), duodenal ulcer (DU), and X-ray negative dyspepsia (XND) as regards clinical features, external factors of possible importance for gastritis and cancer, gastroscopic appearance, and histological gastric mucosal changes. The project lasted one year and comprised 93 Icelandic and 88 Danish patients. A large number of comparisons showed a high degree of similarity between Icelandic and Danish patients. Significant differences were found in tobacco consumption (DK greater than IS), duration of symptoms in XND (IS greater than DK), whereas the positon ratio of GU (IS less than DK) and acetylsalicylic acid consumption (DK greater than IS) showed non-significant trends. Significant difference was found between the occurrence of diffuse macroscopic changes of the gastric mucosa (IS greater than DK), which corresponds to the histological differences to be described in a subsequent article.

Adolescent↗