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Biomedical subjects

M Wurzel

Publications and source records attributed to M Wurzel.

33 records · Page 2Linked to original sources
PubMed1979

Unusual electrocardiographic presentation of idiopathic hypertrophic subaortic stenosis.

A patient with idiopathic hypertrophic subaortic stenosis and normal coronary arteries, with dynamic electrocardiographic changes resembling acute myocardial ischemia, is presented. A definite association between the electrocardiographic changes and the idiopathic hypertrophic subaortic stenosis cannot be absolutely confirmed; however, the findings demonstrate the broad spectrum of electrocardiographic presentation in this disease.

Cardiomyopathy, Hypertrophic↗
PubMed1977

Evaluation of the exercise test in patients with angiographically documented coronary artery disease.

100 male patients with at least 75% obstruction of one or more coronary arteries were subjected to submaximal exercise tests. Among the 73 subjects who had positive tests, 92% of those with one-vessel obstruction had an ST depression of 1 mm, none having more than 2 mm; by contrast, 44% of those with three-vessel disease had an ST depression of more than 2 mm and only 27% on ST depression of 1 mm. Left-ventricular end-diastolic pressure exceeded 15 mm Hg in 86% of the patients who had an ST depression of more than 2 mm but only in 33% of those with a depression of 1 mm; impaired contractility was found in 81% of the former and in 36% of the latter. 92% of those with one-vessel obstruction were able to perform work of 75 and 100 W/min while only 25% of those with three-vessel disease were able to perform the same amount of work. The peak exercise heart rate and systolic blood pressure also decreased with the increase in the number of affected vessels.

Adult↗
PubMed1976

Mitral stenosis with pulmonary hypertension. Long-term results after mitral valvotomy.

Ten patients suffering from tight mitral stenosis with severe pulmonary hypertension were operated on and followed up for one to nine years after operation. There was no operative or postoperative mortality. Postoperative hemodynamic studies were performed on seven of the 10 patients. One patient was evaluated twice--one month and seven months after surgery. The condition of all patients improved after operation and regression of severe to extreme pulmonary hypertension was documented in the seven patients on whom the hemodynamic studies were repeated. Hemodynamic and clinical improvement was greatest in young patients with a shorter duration of disease and a normal sinus rhythm prior to operation. The results indicate that a severe degree of pulmonary vascular resistance in mitral stenosis is largely reversible, provided that the obstruction is adequately relieved.

Adolescent↗
PubMed1970

Splitting of second heart sound in patients with aortic regurgitation.

The intervals between the two components of the second heart sound (A2-P2), measured from the phonocardiograms of 50 patients with severe aortic regurgitation, were compared with those of 57 normal subjects. During expiration the second sound was single or closely split in both groups. Inspiratory augmentation of the A2-P2 interval of less than 0.02 sec occurred in one normal subject (2%) and in 42 patients with aortic regurgitation (86%). Thus the great majority of patients with severe aortic regurgitation had either a single or a closely split second heart sound during both phases of respiration. The mean Q-A2 intervals (rate corrected) of 30 patients, in whom severe aortic regurgitation was documented by contrast angiographic studies, were longer than those of normal subjects during both phases of respiration, and the difference was statistically more significant (P < 0.02) during inspiration. Thus prolongation of the Q-A2 interval was the main factor responsible for the disappearance of the normal asynchrony of semilunar valve closure, in patients with aortic regurgitation.

Adolescent↗