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M Wutkiewicz

Publications and source records attributed to M Wutkiewicz.

26 records · Page 2Linked to original sources
PubMedDate not supplied

The activity of glutamate decarboxylase and the turnover of gamma-aminobutyric acid in spontaneously hypertensive rats.

The activity of glutamate decarboxylase (GAD) in the whole brain, hypothalamus, cerebellum, as well as in the brain after excision of the hypothalamus and cerebellum, is significantly lower in hypertensive rats (SHR) than in normotensive ones (NR). Moreover, the gamma-aminobutyric acid (GABA) turnover rate is lower in the whole brain in SHR. The obtained results indicate that in the arterial hypertension the activity of GABA-ergic system is impaired.

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PubMedDate not supplied

Studies on the cause of changes of reactivity to hexobarbital in spontaneously hypertensive rats (SHR).

The hypnotic action of hexobarbital is weaker in spontaneously hypertensive rats (SHR) than in Wistar rats. The difference does not appear in young rats (up to the sixth week of life) and appears gradually concomitantly with maturation of animals. There was no correlation between the changes of reactivity to hexobarbital and development of hypertension. The rate of metabolism of hexobarbital was similar in SHR and Wistar rats. There is a close relationship between the changes in reactivity to hexobarbital and psychomotor activity: both are significantly higher in SHR than in Wistar rats. The results suggest that the main cause of a weaker action of hexobarbital in SHR is higher intensity of stimulatory processes in the central nervous system.

Aging↗
PubMedDate not supplied

Functional state of GABA-ergic system in spontaneously hypertensive rats.

The concentration of GABA in the whole brain and hypothalamus of spontaneously hypertensive rats (SHR) was significantly lower than in normotensive rats (NR). The ivc injections of GABA offered less protection against electrogenic convulsions in SHR than in NR. These results suggest that lower concentration of GABA in the CNS of SHR may be one of factors responsible for different behavior of SHR and their altered responsiveness to psychotropic drugs.

Animals↗
PubMedDate not supplied

Pharmacodynamics and pharmacokinetics of some hypnotic drugs in spontaneously hypertensive rats (SHR).

Hypnotic action of barbiturates (hexobaribtal, cyclobarbital-Ca, phenobarbital, barbital) chloral hydrate, glutethimide was investigated in spontaneously hypertensive Okamoto-Aoki rats (SHR). Hypnotic effect of investigated drugs was decreased in hypertensive rats comparing with normotensive animals. The decrease in the hypnotic effect was related to the increase of the threshold hypnotic dose. No changes were observed in the pharmacokinetic parameters of hexobarbital and barbital and in the rate of crossing of blood-brain barrier by the latter drug in SHR rats. The results suggested that the decrease of hypnotic activity of investigated drugs did not depend on the hypertension but they were produced by the hyposensitivity of CNS to hypnotic agents. The latter phenomenon appeared as the result of some biochemical changes in the brain tissue.

Animals↗
PubMedDate not supplied

Interaction of hydralazine with barbiturates.

Barbiturates given together with hydralazine significantly change the hypotensive effect of the latter. The final effect depends on the kind of barbiturate, time of its administration, and initial functional state of the circulatory system. Hydralazine given together with barbiturates significantly prolongs their hypnotic action and shortens the latency of that action. In the case of a short-acting barbiturate, hexobarbital, this effect appears in normotensive rats only if the barbiturate is given 60 min prior to hydralazine administration.

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