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Biomedical subjects

M X Zhu

Publications and source records attributed to M X Zhu.

4 recordsLinked to original sources
PubMed1990

[Effect of diphenylhydantoin sodium in causing deformity and that of folic acid preparations for its prevention].

Pregnant rats were divided into four groups. The groups A, B and C were intraperitoneally injected with DPH during the 9 to 11 days of gestation in doses of 75 Mg/kg/day. The groups A and B were supplemented with a mixture of folic acid (FA) or with FA alone in the food fed during pregnancy. The results showed that DPH induced a significant decrease in the body weights and lengths of fetal rats (P less than 0.01), but induced an increase in the incidences of subcutaneous bleeding (P less than 0.05) as well as skeletal and internal malformation (P less than 0.05). The supplement of FA or a mixture of FA in the food fed during pregnancy exhibited partial preventive effects on DPH to induce teratogenicity. The effect of a mixture of FA was better than that with FA alone in reducing the incidences of internal abnormalities and agenesis of the bones of the distant phalanges and subcutaneous bleeding.

Abnormalities, Drug-Induced↗
PubMedDate not supplied

Reduction of the teratogenic effects of phenytoin by folic acid and a mixture of folic acid, vitamins, and amino acids: a preliminary trial.

Four groups of pregnant rats were used to study the effects of dietary supplements of folic acid (FA) alone or a mixture of FA, vitamins (Vit), and amino acids (AA) on the teratogenic effects of phenytoin (PHT). Groups A, B, and C received intraperitoneal (i.p.) injections of high-dose (75 mg/kg/day) phenytoin (PHT) between 9 and 11 days of gestation, while the controls, group D, rats received distilled water. The diet was modified in groups A and B. Group A received a mixture of FA, Vit, and AA, while group B received FA supplementation alone. Groups C and D received a regular diet. We found that PHT, when administered without dietary supplementation, resulted in a decrease in weight and length of the fetuses, an increased rate of subcutaneous (s.c.) bleeding, a retardation of ossification centers, and an increased number of malformations. Supplementation of the diet with FA alone or FA with Vit and AA resulted in statistically greater fetal weight and length, decreased subcutaneous bleeding, more ossification centers, and fewer malformations. The mixture of FA and Vit and AA was superior to FA alone in reducing the incidence of internal abnormalities, ossification abnormalities of the distant phalanxes, and s.c. bleeding.

Amino Acids↗