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Biomedical subjects

M Xue

Publications and source records attributed to M Xue.

At least 37 records · Page 2Linked to original sources
PubMed2000

[Is Gly460Trp variant of alpha-adducin associated with essential hypertension in the Hans of Chinese population].

OBJECTIVE: To determine whether the variant of adducin alpha subunit (alpha-adducin) is in association with essential hypertension in the Hans of Chinese population. METHODS: One hundred and eighty-three patients with essential hypertension and 129 normotensive subjects were included in this study. Genomic DNA was isolated from 3 ml of whole blood. Polymerase chain reaction, single-strand conformational polymorphism and DNA sequencing analysis techniques were used to detect the variant in the exon 10 of alpha-adducin gene. The clinical data of height, weight and blood pressure were also measured in all subjects. RESULTS: A G-->T substitution at nucleotide 614 in exon 10 of alpha-adducin gene which resulted in the Gly460Trp variant was found in the Hans. The distribution of Gly/Gly, Gly/Trp and Trp/Trp genotypes was coincident with Hardy-Weinberg equilibrium and there were no statistical differences in the three genotypes and Trp allele frequencies between hypertensive and normotensive subjects (P>0.05). The variant of alpha-adducin genotypes was not associated with any significant differences in age, body mass index and blood pressure. CONCLUSION: A G-->T substitution at nucleotide 614 in exon 10 of alpha-adducin gene is found, but there is lack of the association between the variant of alpha-adducin gene and essential hypertension in the Hans of Chinese population.

Adult↗
PubMed2000

[Change of plasma cellular fibronectin values in hypertension disorders of pregnancy].

OBJECTIVE: To investigate change of plasma values of cellular fibronectin (cFN) in pregnant women with hypertension diseases. METHODS: One hundred and twelve pregnant women were assigned into five groups according to definition of hypertension diseases in pregnancy published by the National Working Group on Hypertension. The values of plasma cFN were measured with enzyme-link immunosorbent assay (ELISA). Statistical tests were performed with Variance Analysis (Scheff's post-hoc). RESULTS: Plasma cFN values in women of preeclamptic group (12.25 +/- 4.00) mg/L and superimposed preeclamptic group (11.33 +/- 3.74) mg/L were both significantly higher than those of normal group (5.06 +/- 1.33) mg/L (P < 0.01). However, cFN values were not statistically different between women of chronic hypertension or transient hypertension and of normal women (P > 0.05). CONCLUSION: The clinical detection of plasma cFN values appears to be useful in differentiating various hypertension diseases of pregnancy and in selection of relevant treatment regimen.

Female↗
PubMed2000

[Study on biocompatibility of skin reproductive membrane].

OBJECTIVE: To study the biocompatibility of skin reproductive membrane. METHODS: According to ISO's standards, the extractions of the skin reproductive membrane were prepared, and the acute systematic toxicity test, primary skin irritant test, cytotoxicity test, gene expression of type I collagen and fibronectin were detected to evaluate the biocompatibility of skin reproductive membrane. RESULTS: All of those tests showed negative results. CONCLUSION: The skin reproductive membrane has excellent biocompatibility in the level of the systematic, cellular and molecular biology.

Animals↗
PubMed1999

[Effect of in vitro interferon on bone marrow megakaryocyte in patients with idiopathic thrombocytopenic purpura].

The effect of rIFN alpha-2a on the megakaryocyte colony growth and maturation was observed in 33 patients with idiopathic thrombocytopenic purpura (CITP) in vitro by plasma clot cultures and by GP III a McAb and ABC kit. Twenty five healthy persons were in the control group. The results showed that the number of colony formation units of megakaryocyte in the patients was similar to that in the controls, but the diameter and area levels of megakaryocyte in the patients were lower. The ratio of inhibition of rIFN alpha-2a on megakaryocyte progenitors colony growth was significantly lower in the patients and was lowest in the group with increasing number of megakaryocytes on bone marrow smear. The rIFN alpha-2a had no effect on promoting the megakaryocyte maturation. Since this study has indicated that the inhibition of rIFN alpha-2a on colony formation unit of megakaryocyte is slight in CITP, interferon therapy should be a suitable prescription for the CITP patients who have an increasing number of megakaryocyte on bone marrow smear.

Adolescent↗
PubMed1999

[Stress-adaptation of bone].

Loading mechanotransduction sensors on the membrane of bone cells or osteoblasts can improve bone mechanisms and influence second messages, growth factors, bone matrix and oncogenes. The response of bone to stree is preportion to the magmititude of the stress. Stress-adaptation of bone is related with the magnititude, perporties, frequency time of stress.

Adaptation, Physiological↗
PubMed1999

[A comparative study on cytocompatibility of medical PVA and intelligent PVA-g-NIPAAm hydrogels].

"Intelligent" Polymers which resonse with large property changes to small physical or chemical stimuli are attracting more and more attention in the field of medical science. One trend in the area is to modify some conventional medical polymers to form intelligent biomaterials. This investigation was designed to evaluate and compare in vitro cytocompatibility of PVA hydrogel, which could be used as a kind of solid support with good biomcompatibility, and PVA-g-NIPAAm, which was produced by irradiation grafting of NIPAAm onto the said PVA hydrogel support. Cytotoxicity test was carried out with a modified Cell Relative Growth Rate test (RGR test). On the day 2, day 4 and day 7, the RGRs of the PVA hydrogel were 82%, 90% and 102% respectively while the RGRs of the PVA-g-NIPAAm were 77%, 86% and 100%. The grades of the cytotoxicity of the PVA and PVA-g-NIPAAm hydrogels were 0, so they had no cytotoxicity as judged by our tests. After 24 hours, cells in direct contact with the two kinds of samples were observed morphologically through the Olympus inverted microscope and had a normal development. The conclusion suggests that irradiation grafting is a good way to modify conventional medical polymers to produce intelligent biomaterials.

Acrylamides↗
PubMed1998

Morphological study by an 'in vivo cryotechnique' of the shape of erythrocytes circulating in large blood vessels.

Changes in the shape of erythrocytes circulating in large blood vessels of mice were examined by our 'in vivo cryotechnique'. The abdominal aorta and inferior vena cava (IVC) were cut vertically with a precooled knife and simultaneously an isopentane-propane mixture (-193 degrees C) was poured over them for freezing. They were freeze-substituted in acetone containing 2% osmium tetroxide. Some specimens were embedded in Quetol-812, and thick or ultrathin sections were examined by light or transmission electron microscopy. Serial ultrathin sections were used to reconstruct 3-dimensional images of native erythrocytes. Others were transferred into t-butyl alcohol and freeze-dried for scanning electron microscopy. The tissue surfaces were sufficiently frozen to prevent large ice crystal formation, and erythrocyte shapes were also preserved. The shapes of circulating erythrocytes appeared to be varied in the abdominal aorta but typical biconcave discoid shapes were rarely observed. Conversely, erythrocytes were approximately biconcave discoid in shape in the IVC. Our in vivo cryotechnique was useful for clarifying the in vivo morphology of erythrocytes circulating in large blood vessels.

Animals↗
PubMed1998

[Study on the characteristics of brucellosis on the Baicaopo Pasture].

To study the current situation and characteristics of brucellosis on Baicaopo Pasture, a sero-epidemiological survey was conducted among local people, animals together with nearby county livestocks from Breed-improvement Stations, Bingdi township and Rekejue township which are far away from the pasture. The results showed that the infection rates of brucellosis in humans and yaks on the Baieaopo Pasture were 31.03% and 47.19% respectively, apparent higher than those in other places. There were more infected cases among local veterinarians and herdsmen than among other jobs. Young adults seemed to be at most risk.

Adolescent↗
PubMed1998

Influence of percentage of osseointegration on stress distribution around dental implants.

OBJECTIVE: Stress around implants may lead to bone resorption and loss of the implant. The present study examined the influence of percentage of osseointegration at the implant-bone interface on the transmission of occlusal forces for endosseous dental implants. METHODS: The three-dimensional finite element method used in the study was built from data obtained from slices of dental computed tomography scans. The study modeled a 3.75 x 10-mm cylindric implant placed in an edentulous mandible. Varying the elastic parameters assigned to the implant-bone interface, a load of 35 N was applied at the occlusal surface of the restoration at the vertical axis of the implant. Maximum principal stress, minimum principal stress and Von Mises stress were calculated. RESULTS AND CONCLUSIONS: The most extreme stresses in the bone were always located around the neck of the implant. Those stresses in the implant-tissue interface decreased in inverse proportion to the increase in percentage of osseointegration. These results indicate the value of osseointegration in the aspect of mechanics.

Alveolar Process↗
PubMed1998

[The research on GH composite material of artificial bone implant in animal]

OBJECTIVE:To improve modeling different complex forms ability of pure hydroxyapatite.METHODS: Medicial gelatin and hydroxyapatite were compounded to form GH composite artifical bone.It was implanted in the tibial bone of six adult female New Zealand white rabbits.The rabbits were sacrificed at week 2, 6 and 12 respectively after operation,The bone repairing ability was assessed by histology observation.RESULTS:It connect with bone directly without inflammatory reactions with the muscle tissue.CONCLUSION:It's an ideal replacement material for bone.

Journal Article↗
PubMed1998

[Stess analysis of conical telescope denture using on the prosthodontic treatment for basic teeth combined periodontal diseases]

OBJECTIVE:Periodontal splints were made both on patients with peridontal absorption of three different degrees and on normal situation respectively followed by finite element calculation.The result sugree that the stesses of the supporting tissues redistributed during mastication in accordance with different degrees of periodontal absorption.The more obvious of the pcriodontal absorption is the more stress value of the periodontal supporting tissue decrease,while those of the subbasal supporting tissues increase.

Journal Article↗
PubMed1998

[Analysis of trace Pd in marine deposit samples using laser-excited atomic fluorescence spectrometry].

Laser-excited atomic fluorescence spectrometry and its experimental set-up are introduced in this paper. Using this spectrometer, Pd contents in 36 marine deposit samples of the East-sea continental shelf were analyzed. The results show that the detection limit and the precision of this spectrometer are 50 pg/mL and 6% respectively, and the measurements of Pd in marine deposit samples are reliable.

English Abstract↗
PubMed1997

Oblique proton chemical shift imaging for the presurgical localization of mesial temporal epilepsy.

Precise localization of the epileptogenic zone in patients suffering from mesial temporal lobe epilepsies is a prerequisite for surgery. For this purpose, a scheme for selecting the volume of interest in an oblique plane covering the head, body, and tail of the hippocampal formation (HF) was implemented in a water-suppressed proton chemical shift imaging (CSI) acquisition. This approach, evaluated by consecutively acquired CSI spectra of both temporal lobes, demonstrates that it can potentially be a routine technique for clinical diagnosis. Since the method produces localized spectral detail of the HF, it facilitates a convenient comparison of CSI lateralization to that assessed by HF atrophy (due to sclerosis) using the MRI-volumetry technique.

Adult↗
PubMed1997

[Stress research on support tissues of Buffer-typed conical telescopic removable denture]

In order to explore the biomechanical physiology of Buffer-typed conical telescopic removable denture restoring defected dentition with a preponderance of teeth lost and only a few remained,the authors have studied the stress distribution of the periodontal support tissue of abutments and subbasal support tissue when subjected to forced transfered from removable denture of both Buffer-typed and non Buffer-typed telescopic retainers.The results suggest that occlusal forces can be redistribute through dentures with buffer typed conical telescopic retainers which decrease forces sustained by abutments and increase the ones by subbasal support tissues thus avoiding trauma of abutments while having certain degree if physiological stimuli.We can also decrease the forces transfered to subbasal support tissues by expanding basal areas,so to alleviate the absorption of alveolar ridges.This resut is in accordance with clinical effects.

Journal Article↗
PubMed1997

[Study on the compatibility of slip casting aluminous ceramic crowns]

One of the key factors for a good slip casting aluminous ceramic crown is good compatibility between its core material and the veneering porcelain.The chemical and thermal compatibility of two slip casting aluminous ceramic crown systems(In-Ceram and GI-I) were investigated by means of SEM and EDAX,thermal shock tests were also performed to evaluate the crazing resistance.The results showed: the crazing resistance of In-Ceram was 158 degrees centigrade,and that of GI-I was degrees centigrade;there existed tightly bonded interfaces between the slip casting aluminous ceramic cores and the veneering porcelains in both of the two systems,where ion transferences were found.The results also suggested good compatibility of the two slip casting aluminous ceramic crown systems.

Journal Article↗
PubMed1997

[Three dimensional FEM analysis of stress distribution around dental implants to estimate the influence of the length]

The effect of the length of implants on stress distribution is one of the important subjects in implantology.In this study,Three dimensional finite element methods model was constructed by dental CT images,The purpose of this study was to evaluate the stress distribution in bone adjacent to an implant after application of loading in horizontal,oblique and vertical direction.It was show that the highest stress occured at the cervical bone margin adjacent to the implant only 10% decrease in inverse two times increase in implant length,and correlated little to the implant length,therefore,it was unnecessary to emphasize the length of the implants in clinic.

Journal Article↗
PubMed1997

[Development of a SIRI-TOFMS and the application research progress].

The only one set of Sputter Initiated Resonance Ionization-Time of Flight Mass Spectrometer (SIRI-TOFMS) in China was designed and developed. A liquid gallium ion source with micron level diameter of beam, frame-style piezoeletric ceramic sub-micron sample manipulator, a secondary electron imaging system and a computer controlled precise targeting system as well as a real colour big screen image displaying system were added so as to improve its microanalysis capability. By means of this apparatus, trace analysis of Au in minerals and Cu in standard steel samples were carried out. The detection limit of them is 40ng/ and microg/g level, respectively. Aside from the above detections, other preliminary researches ere also performed.

English Abstract↗