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M Y Azbel

Publications and source records attributed to M Y Azbel.

8 recordsLinked to original sources

Unitary mortality law and species-specific age.

Extensive demographic studies relate ageing to the increase in mortality, terminated by the species-specific lifespan limit. Meanwhile, recent experiments demonstrate that medfly mortality decreases at older ages, and challenge a limited lifespan paradigm. This paper presents a unitary mortality law, which relates the controversy to the population heterogeneity. For relatively high heterogeneity it predicts unitarily vanishing old age mortality; this is verified with medfly data. For relatively low heterogeneity it predicts precipitous drop in mortality fluctuations in old age. This is verified with demographic data. If comprehensive studies verify the life expectancy relation to a suggested genetic species-specific age, then the life expectancy may be genetically manipulated. If the studies verify a unitary law of mortality, the results may be generalized to all species. A phenomenological model of mortality is presented.

Aging↗

DNA sequencing and melting curve.

The dependence of DNA absorbance (for light at about 260 nm) on temperature is related to a specific DNA sequence structure in the vicinity of DNA thermal denaturation (the so-called DNA melting or coiling). A straightforward analysis of the experimental DNA melting curve allows us to determine the lengths, the A+T content, and the location in DNA of certain domains. In the case of a specific DNA fragmentation, the order of fragments in DNA can be learned from this analysis, nondestructively and quickly, without fractionating the fragments and other methods of fragmentation. If the DNA nucleotide sequence is known except for some sites and uncertain portions, the analysis determines these sites and the accuracy of the sequence at the portions. This information may complement exact methods of DNA sequencing. The proposed analysis is applied to bacteriophage phiX174, whose melting curve is known. The results are compared to and found to be in an excellent agreement with the known phiX174 nucleotide sequence.

Base Sequence↗