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M Y Fan

Publications and source records attributed to M Y Fan.

25 records · Page 2Linked to original sources
PubMed1987

Rickettsial and serologic evidence for prevalent spotted fever rickettsiosis in inner Mongolia.

A field study in northeastern Inner Mongolia, People's Republic of China, in June of 1985 demonstrated a spotted fever group rickettsiosis. Two strains of spotted fever group rickettsiae were isolated. One strain was obtained from the blood of a patient with an eschar, regional lymphadenopathy, and history of a recent tick bite. The other strain originated from ova of ticks, Dermacentor nuttalli. These represent the second isolate of a spotted fever group rickettsia from a human and the first isolate from tick ova in the People's Republic of China. Antibodies to these rickettsiae were demonstrated by indirect immunofluorescence in the sera of 4% of healthy children and 34% of healthy human adults, in 58% of sheep, and in 76% of cattle in the same location. Hemolymph test revealed rickettsiae in 6 of 36 D. nuttalli examined.

Adolescent↗
PubMedDate not supplied

Sulfate metabolism in experimental diabetes.

Previous studies have indicated altered rates of sulfate clearance in experimental diabetes, but have disagreed on the magnitude and direction of change of serum sulfate, or its impact on tissue sulfate concentrations. The present study was undertaken in order to investigate the temporal effects of streptozotocin-induced diabetes on sulfate pools in the rat. In contrast to some earlier reports, we found no effects of diabetes on serum sulfate concentrations throughout 12 weeks of disease, as measured by ion chromatography. However, marked increases in sulfate concentration were found in liver cytosol (3.5-fold; p less than 0.0005) and kidney (1.7-fold; p = 0.002) by 7 weeks. The measurement of inulin space demonstrated that the changes in hepatic sulfate were due to increased concentrations of the ion in the cell cytosol. Normal serum sulfate concentrations, together with reports of increased renal clearance of sulfate in diabetes, suggest an intracellular origin of the excess cytosolic sulfate. Glucose did not affect the uptake of sulfate by renal mesangial cells in culture. These aberrations in sulfate metabolism are not such as to compromise biological sulfation reactions, and cannot account for reported changes in the incorporation of sulfate into basement membrane proteoglycans during diabetes.

Animals↗
PubMedDate not supplied

Epidemiology and ecology of rickettsial diseases in the People's Republic of China.

Since 1949, information on rickettsial diseases in the People's Republic of China has been virtually nonexistent in the West. This is the first comprehensive review of the ecology and epidemiology of Chinese rickettsial diseases to be published outside the People's Republic. At least five rickettsioses exist in China: scrub typhus, murine typhus, epidemic typhus, Q fever, and one or more spotted fever-group (SFG) rickettsioses. Although epidemic typhus has been controlled and scrub typhus has abated in many areas, murine typhus, Q fever, and SFG rickettsiosis are important public health problems. Serologic surveys indicate high prevalences of antibodies to Coxiella burnetii, Rickettsia tsutsugamushi, and SFG rickettsiae in some regions; these rickettsiae have been isolated from humans, arthropods, and animals. Doxycycline has emerged as the best treatment for murine typhus, epidemic typhus, and scrub typhus. China offers both opportunities and challenges for the investigation and alleviation of the problems of rickettsial diseases.

Adult↗