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Biomedical subjects

M Y Zhao

Publications and source records attributed to M Y Zhao.

11 recordsLinked to original sources
PubMed2000

[Detection of Toxoplasma infection in women with gynaecologic neoplasms using ELISA].

OBJECTIVE: To understand the concurrent in Toxoplasma infection among women with cervical cancer. METHODS: The anti-Toxoplasma IgG, IgM antibodies (Abs) and circulating antigens (CAg) in 247 sera (from 50 cases with cervical cancer in group 1, 59 cases with gynaecological benign tumors in group 2 and 138 cases with other diseases in group 3) were detected by ELISA. RESULTS: The total positive rates of the CAg and the Abs in the three groups were 44.0% (22/50), 25.4% (15/59) and 20.3% (28/138), respectively. The positive rates were 20.0%, 11.9% and 10.9%, respectively for IgG 20.0%, 13.6% and 8.7%, respectively for IgM and 14.0%, 5.1% and 1.4% respectively for CAg. CONCLUSION: The Toxoplasma infection rate of the cervical cancer group was higher than those of the other two groups, particularly the positive rates of CAg and IgM.

Animals↗
PubMed1999

Lymphocyte subsets and sister-chromatid exchanges in the students exposed to formaldehyde vapor.

The present report evaluates the effects of formaldehyde (FA) exposure on peripheral lymphocytes by using both genetic and immunological parameters. Twenty-three non-smoking students in the study had inhalation exposure to 0.508 +/- 0.299 mg/m3 of FA for a period of 8 weeks (3h x 3 times each week) during anatomy classes. As for composition of lymphocyte subsets after FA exposure, significant increase was found in the percentage of CD19 (B cells), while significant decrease was observed in CD3 (total T cells), CD4 (T helper-inducer cells), and CD8 (T cytotoxic-suppressor cells) with a P < 0.01. Increase in the ratio of T-helper-inducer cells to T-cytotoxic-suppressor cells (T4/T8) was also observed with statistical significance after exposure (P < 0.001). In the meanwhile, no significant difference (P > 0.05) was reported between lymphocyte proliferation rate and sister-chromatid exchange (SCE) at the exposure level and duration. It is suggested that the lymphocyte subsets may be most susceptible to the effects of FA, though a single immunological endpoint is rarely related with pathophysiological interpretation.

Adult↗
PubMed1997

Micronuclei in nasal mucosa, oral mucosa and lymphocytes in students exposed to formaldehyde vapor in anatomy class.

The frequency of micronuclei (MN) in cells of the nasal mucosa, oral mucosa and in lymphocytes was evaluated for 25 students in anatomy classes exposed to formaldehyde (FA) over an 8-week period. Each student served as his or her own control. The time-weighted average concentration (TWA) of formaldehyde in anatomical laboratories and in students' dormitories was 0.508 +/- 0.299 mg/m3 and 0.012 +/- 0.0025 mg/m3, respectively. A higher frequency of micronuclei was observed in nasal and oral exfoliative cells after formaldehyde exposure (3.85 +/- 1.48 vs 1.20 +/- 0.676 and 0.857 +/- 0.558 vs 0.568 +/- 0.317, paired-t test: P < 0.001 and P < 0.01, respectively). No significant increase in the frequency of lymphocyte micronuclei was found after formaldehyde exposure (P > 0.05). The present study shows that nasal mucosa cells exposed through respiration are the chief target of FA-induced genotoxic effects.

Embalming↗
PubMed1994

The study of health effects of vinyl chloride air pollution on population.

A series of indicators, including serum lysozyme activity, G-banding chromosome aberration (G-banding CA) analysis, sister chromatid exchanges (SCEs), chromosome aberration (CA), T-lymphocyte transformation rate (TcTR), gamma-GT, GPT and AKP, were employed in the present survey among occupationally vinyl chloride (VC) exposed workers and inhabitants living in VC polluted area in a polyvinyl chloride (PVC) factory. The results showed that the serum lysozyme (S-LZM) activities in Group 3 (adult inhabitants exposed to 0.20 mg/m3 VC for at least 8 years), Group 2 (workers exposed to 4.1 mg/m3 for at least 7 years occupationally), Group 1 (workers exposed to 25.7 mg/m3 for at least 2 years) were significantly higher than control. G-banding CA analysis showed that the total chromosome breakage rates in both Groups 1 and 2 were higher, but no difference existed between Group 3 and control. Only Group 1 was observed having higher SCEs, CA level and lower TcTR than control. AKP levels in Groups 1 and 2 were higher than control, but no gamm-GT and GPT differences were found among groups. The study also suggests that G-banding CA analysis is more sensitive than CA and SCEs.

Adolescent↗
PubMed1990

Dynamic observation on thyroid function in severe head injury.

The dynamic changes of thyroid hormone levels in patients with severe head injury were observed. The results showed that the serum thyroid hormone levels changed rapidly within several hours after the injury and the mean levels of serum total T3 and T4 (TT3, TT4) decreased while high reverse triiodothyronine (rT3) increased significantly. Serum TT3, TT4 and rT3 levels returned to normal gradually in 2 to 3 weeks after the injury in the surviving group, whereas serum total T4 gradually declined and rT3 steadily increased in the fatal group. The mean levels of serum TSH remained unchanged in both groups. Therefore, the use of the levels of serum thyroid hormones as adjuvant indices can be helpful in making pertinent judgements of the severity and prognosis of severe head injuries.

Adult↗
PubMed1987

Blindness from intracranial tumors: a clinical analysis of 60 cases.

We analyzed the cause of blindness in 60 people with intracranial tumors. Twenty-three (38.3%) had binocular blindness, thirty-seven (61.2%) had monocular blindness. The most common tumors producing blindness were pituitary chromophobe adenomas and craniopharyngiomas. Blindness in this series resulted usually from intracranial tumors, which directly or indirectly involved the optic nerve or optic chiasma. These tumors were sometimes misdiagnosed when these patients were first examined by physicians. Specific ophthalmic examinations should permit the diagnosis to be made earlier.

Adolescent↗