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Biomedical subjects

M Yaldiz

Publications and source records attributed to M Yaldiz.

15 recordsLinked to original sources
PubMed2005

The management of lichen planus with low-molecular-weight heparin (enoxaparin).

The aim of this study is to evaluate the efficiency of low-dose, low-molecular-weight heparin (enoxaparin) in the treatment of lichen planus (LP). Twenty-four patients clinically and histopathologically diagnosed as LP with intense pruritus were treated with 3 mg of enoxaparin (Clexane), subcutaneously once a week for 4-14 weeks. Complete remission was observed in 20 of 24 patients (83%) who had widespread cutaneous involvement, but no or minimal effect was observed in four of 24 patients, three of whom had chronic hypertrophic LP. Low-dose enoxaparin was observed to be effective in the treatment of LP without any side-effects. Enoxaparin may be an effective and simple alternative therapy for LP.

Adolescent↗
PubMed2004

P53, c-erbB-2 expression and steroid hormone receptors in breast carcinoma: correlations with histopathological parameters.

OBJECTIVE: The aim of the study was to evaluate the p53 tumor suppressor gene, c-erbB-2 and steroid hormone receptor expression in breast carcinoma by immunohistochemistry and to correlate them with different histopathologic parameters. MATERIALS AND METHODS: p53, c-erbB-2, steroid hormone receptors and their correlation with age, tumor size, histological grade, axillary lymph-node status, and menopausal status were investigated in 65 breast carcinoma cases. All markers were measured immunohistochemically on paraffin sections. Association between estrogen receptor (ER), progesterone receptor (PgR), p53 and c-erbB-2 expression and clinicopathologic variables were assessed by the chi-square test for qualitative parameters. RESULTS: c-erbB-2 staining was found in 35.3% of breast carcinomas and was associated with ductal subtype and age under 35 (p = 0.022, p = 0.003, respectively); p53 staining was seen in 27.6% of cases and was associated with high histological grade and postmenapausal status (p = 0.038, p = 0.002, respectively). Progesterone receptor expression was associated with positive axillary status (p = 0.003). CONCLUSION: We concluded that expressions of c-erbB-2, p53, ER, and PgR may be used in the evaluation of breast carcinoma. Therefore the present study suggests that p53 expression is a marker of high histological grade in postmenopausal status, and that c-erbB-2 expression is associated with histologically ductal subtype.

Adult↗
PubMed2002

Experimental study on effects of deferoxamine mesilate in ameliorating cisplatin-induced nephrotoxicity.

PURPOSE: Cisplatin (CCDP), an indispensable agent of several chemotherapy protocols, has serious dose limiting side effects, including nephrotoxicity. In this experimental study, we used deferoxamine mesilate (DFO), an iron chelating agent, to ameliorate cisplatin-induced nephrotoxicity. MATERIALS AND METHODS: Sixty adult male bulb-c mice were divided in 6 equal groups. Group 1 received distilled water, group 2 received 100 mg/kg DFO, group 3 received 0.9 mg/kg CCDP, group 4 received 100 mg/kg DFO one hour before 0.9 mg/kg CCDP, group 5 received 1.8 mg/kg CCDP, and group 6 received 200 mg/kg DFO one hour before 1.8 mg/kg CCDP transperitoneally for 10 days. The next day, blood and urine samples were obtained, and all the animals were sacrificed, the kidneys and testes were removed, and histopathologic and biochemical analyses were performed. RESULTS: Low-dose and high-dose CCDP treated mice had significantly more extensive proximal tubular degeneration (p < 0.001) when compared to control animals. Moreover, these changes were significantly less extensive in the mice taking DFO than mice taking CCDP. DFO showed no effect on cisplatin induced testicular histopathology. The cisplatin administration significantly increased the serum urea and plasma creatinin concentrations, and DFO administration prior to CCDP significantly decreased serum urea and plasma creatinin concentrations. CONCLUSION: Our findings suggest that DFO administration may be safe and useful for ameliorating cisplatin-induced nephrotoxicity.

Animals↗
PubMed2002

Cervical biopsy specimens and human papilloma virus positivity in patients with external genital warts.

Cervical biopsy specimens were taken from 16 women with external genital warts in order to diagnose concomitant cervical human papillomavirus (HPV) infection and cervical intraepithelial neoplasia (CIN) according to pathology. Positive HPV infection was detected 56% (9/16) of the patients. Among those patients 66% (6/9) had concurrent subclinical low-grade CIN lesions. One of those patients had a high-grade CIN lesion. It is concluded that cervical HPV infection was rather common in women with external genital warts and it is valuable to examine cervical HPV infection by biopsy to detect concomitant CIN.

Adult↗
PubMed2001

Castleman's disease (giant lymph node hyperplasia) of the neck: a case report.

Castleman's disease (giant lymph node hyperplasia) is an uncommon cause of neck mass. Its cause and pathogenesis are still unknown. Giant lymph node hyperplasia (GLH) usually presents as an asymptomatic solitary mass and can occur anywhere in the head and neck. Diagnostic test results are always inconclusive. Excision and histopathological evaluation are the only ways to make a definitive diagnosis. The disease is curable by surgical excision. A case of GLH presenting as a solitary neck mass in a 68-year-old man is reported. There has been no recurrence during about 7 months.

Aged↗
PubMed2001

Mucinous tumors of the ovary: analysis of 38 cases.

Ovarian mucinous tumors stem from ovarian surface epithelium and are divided into benign, borderline and malignant. It is difficult to differentiate borderline and malignant mucinous tumors. Thirty-eight cases of ovarian mucinous tumors which were diagnosed at the Pathology Department of Dicle University Medical Faculty were reviewed. Of these, 18 (47.3%), six (15.7%) and 14 (36.8%) were benign, borderline and malignant, respectively. The patients' ages ranged from 18 to 67 (average 44.5) years. Bilaterality was detected in 1/18 (5.5%), 0/6 and 4/14 (28.5%) of benign, borderline and malignant mucinous tumors, respectively. Mean tumor size was 26.4 cm. Microscopically, there was no stratification in the benign tumors. The borderline tumors had papillary infoldings and 2-3 layers of atypical epithelial cells but no invasion of the stroma. Malignant tumors had four or more layers of atypical epithelial cells and stromal invasion.

Adenocarcinoma, Mucinous↗
PubMed2001

Survival and reproductive function after treatment of immature ovarian teratoma.

We conducted a clinical and pathologic review of nine patients with immature ovarian teratoma. The histologic grade of the tumor seemed to be a reliable indicator of prognosis. Low stage and low grade immature ovarian teratomas have an excellent prognosis. Platinum-based chemotherapy has been confirmed to be effective in the management of patients with ovarian germ cell tumors. Low grade pure ovarian immature teratoma is a potentially curable disease and a fertility-sparing surgical approach is possible.

Adolescent↗
PubMed2000

Castleman's disease in the porta hepatis.

We report the CT, ultrasonographic, and pathologic features of a localized forms of Castleman's disease in the porta hepatis due to their unusual location. Our report suggests that the CT and the ultrasonographic features of Castleman's disease in these locations without calcifications is nonspecific.

Castleman Disease↗
PubMed2000

Teratogenic effects of propineb on rat skin.

The dithiocarbamates are known to cause dermatitis, conjunctivitis, rhinitis, pharyngitis and bronchitis in humans. The experimental group received Propineb (obtained from Bayer) concentrations of 400 ppm in distilled water five days a week (treatment time three weeks) administered orally by gasric pit. Acute oral LD50 for male rats has been found to be 8,500 mg/kg (Worthing, 1983). The control group (n = 10) received only distilled water. At ultrasonographical examination, there were no resorbed fetuses or stillborns during or after propineb administration. It can be clearly seen that the body weights of the experimental group of litters are lower than those of the control group (p < 0.001). However, the mean length of the experimental litters was identical to the control group of litters (p > 0.05). Under microscopical examination, increased keratinization and hyperplasia were observed in the epidermal cells.

Animals↗
PubMed1999

The effect of high-fat diet on the development of obesity and serum leptin level in rats.

UNLABELLED: Ten male Wistar-albino rats were overfed with high-fat diet (margarine at the dose 40 g/kg body weight/day in addition to standard rat diet) during six months from the age of between 8-12 weeks. Ten male rats received a standard chow for the same period. The body weights of the overfed rats increased time dependently (basal 171.5 +/- 5, at sixth month 268 +/- 19 g), whereas those of the rats fed with standard chow did not increase significantly (basal 177 +/- 6.4, at sixth month 220 +/- 10 g). At the sixth month, mean body fat percentages were 36.3 +/- 6.7% and 24.2 +/- 5.4% respectively. Both total cholesterol-triglyceride levels and mean serum leptin levels were also higher than in the overfed rats (p < 0.01 and p < 0.05 respectively). The livers of all rats were histopathologically normal. CONCLUSION: High-fat diet resulting in an increased body fat percentage in rats is associated with hyperleptinemia, hypercholesterolemia and hypertriglyceridemia.

Animals↗
PubMed1999

Protruding urethral leiomyoma obscuring vaginal introitus: case report.

Leiomyoma is quite rare in the female urethra. We report an additional case to 29 reported in the literature. A multiparous woman presented with a complaint of a gradually enlarging mass causing dyspareunia for the last seven months. The mass was originating from the upper part of the distal urethra with a relatively thin stalk covered by squamous epithelia, and immunohistopathological examination confirmed it as leiomyoma.

Adult↗