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Biomedical subjects

M Yaqub

Publications and source records attributed to M Yaqub.

18 recordsLinked to original sources

Yield of dual endoscopy for positive fecal occult blood test.

OBJECTIVES: Dual endoscopy is frequently performed on the same day in patients whose stools are found to be positive on fecal occult blood testing (FOBT). This is often done to localize the potential sources of GI bleed. The diagnostic yield of same day dual upper endoscopy (EGD) and lower endoscopy (colonoscopy) for the detection of positive FOBT is uncertain. In the era of cost-efficient medical practice, we investigated whether a more evidence-based and structured approach could be used to guide physicians to the workup of patients who present with positive FOBT. METHODS: We performed a retrospective analysis of 309 patients, and 260 patients from this population met our inclusion criteria. Inclusion criteria included FOBT without acute GI hemorrhage, hematochezia, or melena. Patients were required to have had EGD and colonoscopy within the same day (<24 h). RESULTS: Of 260 patients, a total of 135 (52%) patients had positive findings on colonoscopy and a total of 42 (16.1%) patients had positive findings on EGD. Sixteen (6.1%) had positive EGD and negative colonoscopy; 109 (42%) had positive colonoscopy and negative EGD; and 26 (10%) had positive findings on both EGD and colonoscopy. CONCLUSIONS: Colonoscopy should be chosen as the initial procedure of choice in the evaluation of patients who present with positive FOBT. Same day dual endoscopy does not seem to be cost-effective.

Colonoscopy↗

Orelox (cefodoxime) in typhoid fever.

OBJECTIVE: To study the efficacy of Orelox (Cefodoxime) in Typhoid fever in children. SETTINGS: Open, non-comparative, multicentre study carried out in GP settings in various cities of Pakistan. PATIENTS: Children aged 1-15 years were included in the study. Positive Widal test was the only diagnostic inclusion criteria. RESULTS: Four centers participated in the study. Of the total 77 patients (51 males and 26 females), 61 (79%) cured, 5 (7%) improved (less severe signs and symptoms) and 11 (14%) failures. CONCLUSION: Treatment of typhoid fever in this study showed 86% efficacy in producing clinical responses suggesting that this drug can be effectively and safely used in the treatment of typhoid fever in children.

Adolescent↗

Mycosis fungoides associated with florid sarcoid reactions.

We report a 59-year-old woman with disease manifestations diagnosed as mycosis fungoides (MF), as well as findings of sarcoidosis. The concurrence of these two disorders, both of which may be associated with basic immunopathogenic factors, has been reported. Histologically, the cutaneous findings of both non-caseating granulomas and an infiltrate compatible with MF in the same site leads to a discussion of granulomatous MF. Whether granulomatous MF simply represents sarcoidosis developing concomitantly with MF lymphoma or is, in fact, a distinct clinical and histologic type of MF is discussed. Reasons why granulomatous MF, like granulomators Hodgkin disease, might have a more favorable prognosis than the usual type of MF are considered.

Female↗

Reticulate pigmented anomaly.

Reticulate pigmented anomaly of the flexures is a benign, recently described genodermatosis reported to involve the flexural areas as well as the scrotum. Described herein is a twenty-nine year old man in whom the characteristic speckled macules were limited to the scrotal and penile skin. The authors suggest that the anomaly be designated reticulate pigmented anomaly without reference to specific anatomic sites. It is possible that this pigmented eruption of the genitalia is a cutaneous marker of this patient's underlying testicular carcinoma.

Adult↗

L-asparaginase--antileukemia agent.

This paper describes the most recent development in the field of biosynthesis of L-Asparaginase by means of various culture, purification by Column Chromatography, informations of the Catabolite repression of L-Asparaginase and its metabolism in mycobacteria. The separation, purification studies, idea about the effect of different PH on activity, quaternary structure and the effect of specific antibodies on catalytic activity of L-Asparaginase is discussed. This material shows the role of L-Asparaginase in acute lymphocytic leukemia.

Animals↗

L-asparaginase--antileukemia agent.

This paper is an extension of a previous report (Yaqub 1975). Our interest in L-asparaginase is increasing due to the recognition of the fact that it is a best tool against leukemia. In this paper we have tried to discuss (in view of research work, 1973-75) its basic characteristics and its practicability of successfully being used as an antitumour agent.

Animals↗

L-asparaginase-antileukemia agent.

This paper is an extension of a previous report (Yaqub 1975). Our interest in L-asparaginase is increasing due to the recognition of the fact that it is a best tool against leukemia. In this paper we have tried to discuss (in view of research work, 1973-75) its basic characteristics and its practicability of successfully being used as an antitumour agent.

Animals↗

Pigmented penile lesions (fixed drug eruptions) associated with tetracycline therapy for sexually transmitted diseases.

Two men had pigmented penile lesions that were diagnosed as fixed drug eruptions. The lesions developed after ingestion of tetracycline for nongonococcal urethritis and syphilis, respectively. Because use of tetracycline for treatment of sexually transmitted diseases is becoming more common, physicians must be able to recognize the allergic reactions to this drug.

Adult↗